GLP1R and OCT1 variants modulate semaglutide and metformin response in type 2 diabetes [0.03%]
GLP1R和OCT1变异体通过调节司美格鲁肽和二甲双胍的药效来影响2型糖尿病患者的药物反应
Ivan Tourtourikov,Maria Kalinkova,Peter Ivanov et al.
Ivan Tourtourikov et al.
Background: Large consortia link variants in SLC22A1, SLC47A1, and GLP1R to antidiabetic response, yet few data confirm these effects in small real-world cohorts. We tested whether three common polymorphisms translate int...
Wenjian Yang,Gang Wu,Jeffery M Klco et al.
Wenjian Yang et al.
Objectives: Pharmacogenomic testing is rapidly becoming the standard of care in treating pediatric acute lymphoblastic leukemia (ALL). Risk classification of ALL can be performed through whole transcriptome sequencing (WT...
Pharmacogenomic analysis of low-density lipoprotein receptor 3' untranslated region genetic variants influencing rosuvastatin efficacy in Chinese dyslipidemia patients [0.03%]
中国高脂血症患者rosuvastatin药效的低密度脂蛋白受体3'非翻译区基因多态性药代遗传学研究
Keke Wang,Yihua Zhu,Yan Tian et al.
Keke Wang et al.
Objectives: Dyslipidemia is a crucial risk factor for atherosclerotic cardiovascular disease. Although rosuvastatin is widely used, treatment response varies significantly due to genetic variation. This study investigated...
Association of genetic variation with irinotecan infusion reactions and severe toxicity [0.03%]
基因变异与伊立替康输注反应及严重毒性的关联研究
Kelly I Nugent,Lyucheng Huang,Maisa Nazzal et al.
Kelly I Nugent et al.
Irinotecan treatment is often complicated by gastrointestinal, hematological, and infusion-related toxicities, the latter of which typically presents as acute cholinergic syndrome (ACS). While genetic variation in UGT1A1 increases toxicity ...
Annika M Czizik,Hannah Burkett,Joshua C Black et al.
Annika M Czizik et al.
It is unknown how many people in the US have had pharmacogenetic (PGx) testing and whether people want to be tested. We conducted a nationally representative survey of the general US adult population to determine the prevalence of adults th...
Microsampling with dried blood spots and mass spectrometry enables PK/PD profiling of responses to praziquantel in a Schistosoma haematobium-exposed Zimbabwean population [0.03%]
微创采样和基于质谱的药代动力学/药效学分析测定乾血斑试样的吡喹酮暴露效应关系：赞比亚斯氏血吸虫感染人群示例研究
David Twesigomwe,Grace Zdesenko,Takafira Mduluza et al.
David Twesigomwe et al.
Introduction: Praziquantel (PZQ) is commonly used to treat schistosomiasis; however, there is considerable interindividual variability in its efficacy, partly because of genetic variation. Data on this relationship is sca...
Association of VKORC1 and CYP2C9 gene polymorphisms with warfarin dose requirements in a representative Iranian population with cardiac valve replacement surgery [0.03%]
维柯尔基因和细胞色素P450同工酶2C9基因多态性与伊朗心脏瓣膜置换手术患者华法林维持剂量需求的相关性研究
Omid Maleki,Javad Gharechahi
Omid Maleki
Background: Warfarin is a commonly used oral anticoagulant for managing thromboembolic events after cardiac valve surgery. However, its optimal dose varies between individuals, often requiring trial and error to determine...
Targeting cardiomyopathies associated with RASopathies: the role of mitogen-activated protein kinase inhibitors and therapeutic challenges [0.03%]
针对RASopathy相关心肌病的治疗：细胞外信号调节激酶抑制剂的作用及治疗挑战
Valentina Botia-Arciniegas,Natalia Jimenez-Cardozo,Juliana Lores
Valentina Botia-Arciniegas
RASopathies are rare genetic disorders caused by germline mutations in genes that regulate the RAS-mitogen-activated protein kinase (MAPK) pathway, a critical pathway involved in various cellular processes. Disruption of this pathway leads ...
Integrating pharmacogenetics in sport medicine: enhancing treatment precision and preventing unintentional doping violation [0.03%]
运动医学中药物基因组学的整合：提高治疗精度和预防无意违规使用兴奋剂
Guillaume Drevin,Marie Briet,Chadi Abbara
Guillaume Drevin
Pharmacogenetic association of CYP enzymes with therapeutic propofol doses during mechanical ventilation [0.03%]
细胞色素P450酶与机械通气期间异丙酚治疗剂量的药物基因组学关联研究
Chanel Hsiang,Faisal Shakeel,Nicholas Farina et al.
Chanel Hsiang et al.
Propofol is commonly used to sedate patients, but variations in how individuals metabolize the drug may affect dosing requirements. The objective of this study was to explore how genetic variations in CYP450 enzymes, particularly CYP2B6, in...