Association of UGT and CYP genotype-predicted activity with tyrosine kinase inhibitor toxicity [0.03%]
UGT和CYP基因型预测活性与酪氨酸激酶抑制剂毒性的关联性研究
April T Moy,Lia E D&#x;Angelo,Daniel L Hertz
April T Moy
Associations between genetically predicted activity of metabolic enzymes and risks of adverse events from tyrosine kinase inhibitors (TKIs) may inform dosing to optimize treatment outcomes in patients with cancer. The goal of this study is ...
The HTR2A rs6311 and rs6313 polymorphisms and atypical antipsychotics response in schizophrenia: a scoping review [0.03%]
多巴胺D2受体基因（HTR2A rs6311和rs6313多态性）与精神分裂症不典型抗精神病药物反应的关联：系统综述
Nurul Hidayah,Muthi Ikawati,Mustafa Mahmud Amin et al.
Nurul Hidayah et al.
The HTR2A polymorphisms rs6311 (A-1438G) and rs6313 (T102C) have been thoroughly studied for their impact on atypical antipsychotics (AAPs) responsiveness in schizophrenia. However, the results remain inconsistent owing to the complex genet...
Individualized perampanel response and efficacy in patients with refractory epilepsy: the need for ATP-binding cassette B1 genotyping and therapeutic drug monitoring to work in tandem [0.03%]
药代动力学及药物浓度监测联合ABCB1基因型指导帕利哌酮治疗难治性癫痫患者的个体化治疗响应和疗效分析
Ting Zhao,Hong-Jian Li,Hui-Lan Zhang et al.
Ting Zhao et al.
Objective: This study analyzed the correlation and differences between the gene polymorphisms of ATP-binding cassette B1 (ABCB1), which encode the efflux drug transporter P-glycoprotein, and the efficacy and plasma concen...
Knowledge, perception, and attitude toward clinical implementation of pharmacogenomics among healthcare professionals in Pakistan: a cross-sectional study [0.03%]
巴基斯坦医疗专业人员的临床实施药物基因组学的知识、认知和态度：一项横断面研究
Bushra Waheed,Asif Jan,Basmah Abdulaziz Albabtain et al.
Bushra Waheed et al.
Background: As precision medicine advances, integrating pharmacogenomics (PGx) into routine practice requires coordinated efforts among healthcare professionals. This study evaluated the knowledge, attitudes, and percepti...
DPYD polymorphisms in Native populations from the Brazilian Amazon: the absence of the variants in currently recommended clinical genotyping panels [0.03%]
巴西亚马逊土著人群中的DPYD多态性：目前推荐的临床基因分型板中不存在这些变异体
Guilherme Suarez-Kurtz,Paulo C Basta,Jamila Alessandra Perini
Guilherme Suarez-Kurtz
Objectives: We examined the distribution of clinically-relevant DPYD polymorphisms in Yanomami and Munduruku individuals, from Indigenous reservation areas in the Brazilian Amazon. The estimated proportion of Native ances...
The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review [0.03%]
细胞因子基因多态性在抑郁症发病机制中的作用：系统综述
Yuvapriya Kalidasan,Vettriselvi Venkatesan,Suvarna Jyothi Kantipudi et al.
Yuvapriya Kalidasan et al.
Major depressive disorder (MDD) is a multifactorial psychiatric disorder increasingly associated with immune-inflammatory mechanisms. Pro-inflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1...
Evaluating the impact of SDHAF3 p.F53L genetic variant on clinically significant QTc prolongation in patients prescribed high-risk medications: a retrospective pharmacogenetic study [0.03%]
SDHAF3 p.F53L基因变异对高风险药物处方患者的临床显著QT间期延长的影响：一项回顾性药理遗传学研究
Ahmed Aalibraheem,Ana I Lopez-Medina,Choudhary Anwar A Chahal et al.
Ahmed Aalibraheem et al.
Drug-induced QT prolongation (diQTP) can lead to rare, but potentially fatal adverse effects of many medications, yet individual susceptibility varies due to both clinical and genetic factors. SDHAF3 p.F53L (rs62624461) is a genetic variant...
Genetic polymorphisms in ABCB1 and CEP72 genes as pharmacogenetic markers in patients receiving vincristine-based chemotherapy: a preliminary Indian context exploratory study [0.03%]
ABCB1和CEP72基因多态性作为接受长春花生物碱为基础的化疗患者的药物基因组标志物的初步探索研究（印度）
Ramya Sugumar,Harpreet Kaur,Latha M S et al.
Ramya Sugumar et al.
Introduction: Vincristine is limited by its adverse effect of peripheral neuropathy with only a few inconclusive reports of its genetic occurrence. Therefore, the present research work was intended to identify the distrib...
Knowledge and perspectives on pharmacogenomic-guided antidepressant treatment among psychiatrists and primary care practitioners [0.03%]
精神科医师和内科医师对抑郁症个性化治疗的知识和观点
Kendall T Schmidt,Hetanshi Naik,Thuy-Mi P Nguyen et al.
Kendall T Schmidt et al.
Objectives: This study compared psychiatrist and primary care practitioner (PCP) perspectives on pharmacogenomics and barriers to its use in guiding antidepressant prescribing. ...
Low expression of ZFP36L2 causes glucocorticoid resistance in childhood T-cell acute lymphoblastic leukemia [0.03%]
ZFP36L2低表达导致儿童T细胞急性淋巴细胞白血病对糖皮质激素耐药
Yuening Xiang,Mengyan Wang,Shao Xie et al.
Yuening Xiang et al.
Objective: Glucocorticoids (GCs) are essential for the therapy of acute lymphoblastic leukemia (ALL), but glucocorticoid resistance remains a major clinical challenge, and its molecular mechanisms are not fully understood...