Luana da Silva Baptista Arpini,Fernanda Mayrink Gonçalves Liberato,Sabrina da Silva Santos et al.
Luana da Silva Baptista Arpini et al.
Objective: To investigate the association between CFTR genotypes and clinical and nutritional outcomes in children and adolescents with cystic fibrosis (CF) receiving care within the public health system of Espírito Sant...
TWSG1 variation identifies a ustekinumab-response phenotype in patients with inflammatory bowel disease [0.03%]
Mohammed Alkhalifa,Gio R Dela Cruz,Terry Ponich et al.
Mohammed Alkhalifa et al.
Objectives: A genome-wide association study identified that genetic variation in the twisted gastrulation protein homolog-1 gene (TWSG1 rs7242593) was linked to early clinical remission in ustekinumab-exposed patients in ...
Characteristics of initial pharmacogenetic testing and subsequent physician referral behavior in youth mental health [0.03%]
Naomi Lemboye,Madison Heintz,Abdullah Al Maruf et al.
Naomi Lemboye et al.
While prior studies have focused on the clinical utility of pharmacogenetic (PGx) testing, less is known about factors that influence physicians' continued use of PGx testing in routine practice. Using data from the PGx-SParK trial, we exam...
Effects of apolipoprotein E and solute carrier organic anion transporter family member 1B1 gene polymorphisms on statin efficacy and safety in dyslipidemic patients [0.03%]
载脂蛋白E和溶质载体有机阴离子转运蛋白家族成员1B1基因多态性对血脂异常患者他汀疗效及安全性的研究
Xiaohong Wu,Yumei Cai,Yonglong Su et al.
Xiaohong Wu et al.
Objective: To investigate the distribution of the apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) polymorphisms in dyslipidemia patients and their impact on statin efficacy...
The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data [0.03%]
缬沙坦潜在效应和作用途径的全基因组和全表型组关联研究：英国生物银行数据的分析
Shengyin Zeng,Yaxin Li,Yucong Zhang et al.
Shengyin Zeng et al.
Purpose: Valsartan, an angiotensin II receptor blocker, is widely used for hypertension and heart failure. While its cardiovascular benefits are established, its broader pharmacological effects remain incompletely charact...
Application of risk priority number of failure mode and effects analysis to drug-variant pairs for severe cutaneous adverse reactions in Korean and American populations [0.03%]
风险优先数法在韩国人群和美国人群中用于药物与剂型组合的严重皮肤不良反应的风险评估
Hyun Kyung Lee,Min Ju Kang,Hajung Kim et al.
Hyun Kyung Lee et al.
Objectives: Given the varying frequency and significance of genetic factors associated with severe cutaneous adverse reactions (SCARs) across different ethnicities, this study aimed to identify high-risk priority drug-var...
The role of uridine diphosphate glucuronosyltransferase 1A4 polymorphisms on posaconazole exposure [0.03%]
尿苷二磷酸葡萄糖醛酸转移酶1A4多态性对泊沙康唑暴露的影响
Katherine Zhao,Vy Lam,Gregory Eschenauer et al.
Katherine Zhao et al.
Posaconazole is used to treat and prevent invasive fungal infections. Posaconazole metabolism is mediated by the uridine 5'-diphopho-glucuronosyltransferase (UGT) 1A4 enzyme; prior studies have suggested UGT1A4*3 contributes to low posacona...
Prevalence of TPMT and NUDT15 diplotypes in Mexican children with B-cell acute lymphoblastic leukemia [0.03%]
墨西哥B细胞急性淋巴细胞白血病儿童中TPMT和NUDT15复合型的分布状况
Joaquin Garcia-Solorio,Carolina Molina-Garay,Víctor Jesús Sánchez-Martínez et al.
Joaquin Garcia-Solorio et al.
Objective: To characterize the allelic and diplotype variability of TPMT and NUDT15 in pediatric patients with B-cell acute lymphoblastic leukemia from the central-southern region of Mexico. ...
Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis [0.03%]
SLCO1B1，载脂蛋白E和ABCG2基因与Rosuvastatin降脂反应之间的关系：一项荟萃分析
Jianhai Li,Yongkun Deng,Yong Lai et al.
Jianhai Li et al.
Objective: To investigate the effects of SLCO1B1, apolipoprotein E (APOE) and ABCG2 gene polymorphisms on the lipid-modulating efficacy of rosuvastatin. M...
The role of pharmacogenomics and opioid prescribing for infants with surgical congenital heart disease [0.03%]
药理基因组学和阿片类药物的开具在患有先天性心脏病的婴儿中的作用
Rabab M Barq,Shadassa Ourshalimian,Simran Maggo et al.
Rabab M Barq et al.
Objectives: Pharmacogenomic (PGx) variants associated with opioid metabolism and reward pathways may influence pain response and risk of opioid dependence. Infants undergoing surgery routinely receive opioids, and prolong...