The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review [0.03%]
细胞因子基因多态性在抑郁症发病机制中的作用：系统综述
Yuvapriya Kalidasan,Vettriselvi Venkatesan,Suvarna Jyothi Kantipudi et al.
Yuvapriya Kalidasan et al.
Major depressive disorder (MDD) is a multifactorial psychiatric disorder increasingly associated with immune-inflammatory mechanisms. Pro-inflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1...
Evaluating the impact of SDHAF3 p.F53L genetic variant on clinically significant QTc prolongation in patients prescribed high-risk medications: a retrospective pharmacogenetic study [0.03%]
SDHAF3 p.F53L基因变异对高风险药物处方患者的临床显著QT间期延长的影响：一项回顾性药理遗传学研究
Ahmed Aalibraheem,Ana I Lopez-Medina,Choudhary Anwar A Chahal et al.
Ahmed Aalibraheem et al.
Drug-induced QT prolongation (diQTP) can lead to rare, but potentially fatal adverse effects of many medications, yet individual susceptibility varies due to both clinical and genetic factors. SDHAF3 p.F53L (rs62624461) is a genetic variant...
Genetic polymorphisms in ABCB1 and CEP72 genes as pharmacogenetic markers in patients receiving vincristine-based chemotherapy: a preliminary Indian context exploratory study [0.03%]
ABCB1和CEP72基因多态性作为接受长春花生物碱为基础的化疗患者的药物基因组标志物的初步探索研究（印度）
Ramya Sugumar,Harpreet Kaur,Latha M S et al.
Ramya Sugumar et al.
Introduction: Vincristine is limited by its adverse effect of peripheral neuropathy with only a few inconclusive reports of its genetic occurrence. Therefore, the present research work was intended to identify the distrib...
Knowledge and perspectives on pharmacogenomic-guided antidepressant treatment among psychiatrists and primary care practitioners [0.03%]
精神科医师和内科医师对抑郁症个性化治疗的知识和观点
Kendall T Schmidt,Hetanshi Naik,Thuy-Mi P Nguyen et al.
Kendall T Schmidt et al.
Objectives: This study compared psychiatrist and primary care practitioner (PCP) perspectives on pharmacogenomics and barriers to its use in guiding antidepressant prescribing. ...
Low expression of ZFP36L2 causes glucocorticoid resistance in childhood T-cell acute lymphoblastic leukemia [0.03%]
ZFP36L2低表达导致儿童T细胞急性淋巴细胞白血病对糖皮质激素耐药
Yuening Xiang,Mengyan Wang,Shao Xie et al.
Yuening Xiang et al.
Objective: Glucocorticoids (GCs) are essential for the therapy of acute lymphoblastic leukemia (ALL), but glucocorticoid resistance remains a major clinical challenge, and its molecular mechanisms are not fully understood...
Vitamin D receptor regulate placental ABCB1 expression transcriptionally by recruiting coactivator SRC-1 [0.03%]
维生素D受体通过招募共激活因子SRC-1调控胎盘ABCB1转录表达
Shuran Shao,Yu Yan,Lixia Yang et al.
Shuran Shao et al.
Background: P-glycoprotein (P-gp), the most extensively studied ATP-binding cassette (ABC) transporter, is expressed in the apical membrane of syncytiotrophoblast cells and plays a crucial role in placental drug transport...
Prevalence of CYP2C19 phenotypes in patients undergoing a hiatal hernia repair [0.03%]
接受胃食管结合部疝修补术患者的CYP2C19表型流行率
Abdel-Rahman Naser,Keouna Pather,Erin M Mobley et al.
Abdel-Rahman Naser et al.
Objectives: Gastroesophageal reflux disease is primarily treated with proton pump inhibitors (PPIs), which are metabolized by cytochrome P450 2C19 (CYP2C19) in the liver. CYP2C19 polymorphisms affect PPI plasma levels, wi...
Impact of CYP3A5 genotype on tacrolimus pharmacokinetics and clinical outcomes in pediatric patients with Henoch-Schönlein purpura nephritis [0.03%]
CYP3A5基因型对肾炎性紫癜患儿他克莫司药代动力学及临床结局的影响
Huiying Li,Na Li,Xiaoling Tang et al.
Huiying Li et al.
Aim: This study aimed to evaluate the impact of CYP3A5 gene polymorphism on the pharmacokinetics, therapeutic efficacy, and safety of tacrolimus in pediatric patients with Henoch-Schönlein purpura nephritis (HSPN). ...
CFTR genotype-phenotype associations and clinical outcomes in pediatric cystic fibrosis [0.03%]
儿童囊性纤维化患者中CTFR基因型表型关联及临床结局分析
Luana da Silva Baptista Arpini,Fernanda Mayrink Gonçalves Liberato,Sabrina da Silva Santos et al.
Luana da Silva Baptista Arpini et al.
Objective: To investigate the association between CFTR genotypes and clinical and nutritional outcomes in children and adolescents with cystic fibrosis (CF) receiving care within the public health system of Espírito Sant...
TWSG1 variation identifies a ustekinumab-response phenotype in patients with inflammatory bowel disease [0.03%]
TWSG1变异识别出炎症性肠病患者中的乌斯替单抗应答表型
Mohammed Alkhalifa,Gio R Dela Cruz,Terry Ponich et al.
Mohammed Alkhalifa et al.
Objectives: A genome-wide association study identified that genetic variation in the twisted gastrulation protein homolog-1 gene (TWSG1 rs7242593) was linked to early clinical remission in ustekinumab-exposed patients in ...