Space pruning monotonic search for the non-unique probe selection problem [0.03%]
空问剪枝单调搜索在非唯一探针选择问题中的应用研究
Elisa Pappalardo,Beyza Ahlatcioglu Ozkok,Panos M Pardalos
Elisa Pappalardo
Identification of targets, generally viruses or bacteria, in a biological sample is a relevant problem in medicine. Biologists can use hybridisation experiments to determine whether a specific DNA fragment, that represents the virus, is pre...
Sohan Seth,José C Príncipe
Sohan Seth
Mutual information, conditional mutual information and interaction information have been widely used in scientific literature as measures of dependence, conditional dependence and mutual dependence. However, these concepts suffer from sever...
Uses and challenges of bioinformatic tools in mass spectrometric-based proteomic brain perturbation studies [0.03%]
基于质谱的蛋白质组学脑扰动研究中生物信息学工具的应用与挑战
Joy D Guingab-Cagmat,Emilio B Cagmat,Firas H Kobeissy et al.
Joy D Guingab-Cagmat et al.
Mass spectrometry (MS) has become the method of choice to study the proteome of brain injury. The high throughput nature of MS-based proteomic experiments generates massive amount of mass spectral data presenting great challenges in downstr...
A linearly convergent first-order algorithm for total variation minimisation in image processing [0.03%]
适用于图像处理中总变化最小化的线性收敛一阶算法
Cong D Dang,Kaiyu Dai,Guanghui Lan
Cong D Dang
We introduce a new formulation for total variation minimisation in image denoising. We also present a linearly convergent first-order method for solving this reformulated problem and show that it possesses a nearly dimension-independent ite...
Novel hybrid genetic algorithm for progressive multiple sequence alignment [0.03%]
一种新的混合遗传算法在多序列渐进比对中的应用研究
Muhammad Ishaq Afridi
Muhammad Ishaq Afridi
The family of evolutionary or genetic algorithms is used in various fields of bioinformatics. Genetic algorithms (GAs) can be used for simultaneous comparison of a large pool of DNA or protein sequences. This article explains how the GA is ...
Evolutionary history and phylogenetic relationship between Auxis thazard and Auxis rochei inferred from COI sequences of mtDNA [0.03%]
基于线粒体COI序列探讨薄stripe飞鱼和方块飞鱼的进化及亲缘关系
Girish Kumar,Swaraj Priyaranjan Kunal,S K Shyama
Girish Kumar
Tunas of the genus Auxis are cosmopolitan species and the smallest members of the tribe Thunnini, the true tunas. In the present study, COI sequences of mtDNA were employed to examine the evolutionary history and phylogenetic relationship b...
Chakresh Kumar Jain,Ankita Dasgupta,Naina Taneja et al.
Chakresh Kumar Jain et al.
Opportunistic fungal infections, such as zygomycosis, often associated with excessive morbidity and mortality, are increasingly becoming a source of concern worldwide. In the reported investigation, genome analysis of a major opportunistic ...
Hayedeh Ahrabian,Mohammad Ganjtabesh,Abbas Nowzari-Dalini et al.
Hayedeh Ahrabian et al.
One of the fundamental problems in computational biology is the construction of physical maps of chromosomes from the hybridisation experiments between unique probes and clones of chromosome fragments. Before introducing the shotgun sequenc...
Tiratha Raj Singh,Arun Gupta,Prashanth Suravajhala
Tiratha Raj Singh
While it is known that the human genes are regulated by microRNAs (miRNAs), recent links with cancer and other diseases have widely caught interest. With several bioinformatics platforms and approaches on rise that has led to discovery of h...
In-silico analysis for RNA-interference mechanism of α-synuclein to treat Parkinson's disease [0.03%]
α-突触核蛋白RNA干扰治疗帕金森病的机制的计算机分析方法研究
S Seema,R Seenivasagam,K Hemavathi
S Seema
Parkinson's Disease (PD) causing mutations in α-synuclein gene are ALA30PRO, GLU46LYS and ALA53THR. The conformational changes in proteins with respect to all the three mutations were analysed. These were used to predict the structures of ...