Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis [0.03%]
表观基因组甲基化单倍型连锁分析鉴定HLA-DRB1、HLA-DRB5和HLA-DQB1为类风湿关节炎的危险因素
Jing Xu,Haiyan Chen,Chen Sun et al.
Jing Xu et al.
The aim of this study was to compare nonrandom associations between physically adjacent single methylation polymorphism loci among rheumatoid arthritis (RA) and normal subjects for investigating RA-risk methylation haplotypes (meplotype). W...
HLA-G 3'UTR haplotype analyses in HCV infection and HCV-derived cirrhosis, hepatocellular carcinoma and fibrosis [0.03%]
HCV 感染及其衍生肝硬化、肝细胞癌和纤维化中的 HLA-G 3'UTR 基因型分析
Julio Daimar Oliveira Correa,Francis Maria Báo Zambra,Rafael Tomoya Michita et al.
Julio Daimar Oliveira Correa et al.
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. Chronic HCV infection is also an important cause of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCV has the capacity to evade immune surveillan...
Analysis of null deletion polymorphism of glutathione S-transferase theta (GSTT-1), associated with anti-GSTT-1 antibodies development in transplantation [0.03%]
移植物抗GSTT-1抗体阳性与谷胱甘肽S转移酶theta(GSTT-1)基因缺失多态性分析
Manuel Muro-Perez,Gema González-Martínez,Pedro Martínez-García et al.
Manuel Muro-Perez et al.
Glutathione S-transferase theta 1 (GSTT1) is an enzyme involved in phase II biotransformation processes and a member of a multigene family of detoxifying and clearing reactive oxygen species. GSTT1 is polymorphic like other biotransforming ...
Possible impact of HLA class I and class II on malignancies driven by a single germ-line BRCA1 mutation [0.03%]
人类白细胞抗原I类和II类分子可能影响由单一生殖系BRCA1突变驱动的恶性肿瘤
Milena Ivanova,Anastasia Ormandjieva,Rumyana Dodova et al.
Milena Ivanova et al.
This study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations...
Correlation of CTLA-4 polymorphism and the risk of gastric cancer in a Chinese Bai population [0.03%]
CTLA-4基因多态性与中国白族胃癌发病风险的相关性研究
Ping Yan,Shan Kong,Yong Zheng et al.
Ping Yan et al.
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is involved in the regulation of immune responses mediated by T cells. This study aimed to explore the correlation between CTLA-4 gene polymorphisms and the risk of gastric cancer (GC) in...
HLA-A*02:06 allele may be susceptible to myelodysplastic syndrome in Zhejiang Han population, China [0.03%]
中国浙江省汉族人群中的HLA-A*02:06基因型可能是骨髓增生异常综合征的易感因素
Nanying Chen,Fang Wang,Yanmin Zhao et al.
Nanying Chen et al.
The association between HLA loci and haematological malignancy has been reported in certain populations. However, there are limited data for HLA loci at a high-resolution level with haematological malignancy in China. In this study, a total...
Nomenclature for factors of the HLA system, update April, May and June 2023 [0.03%]
2023年4-6月HLA系统因素命名法更新
Steven G E Marsh;WHO Nomenclature Committee for Factors of the HLA System
Steven G E Marsh;WHO Nomenclature Committee for Factors of the HLA System
Xinmeng Guo,Jinning Zhang,Jin Shang et al.
Xinmeng Guo et al.
Gynaecological tumours that threaten the health of women, especially when advanced and recurrent, have remained mostly intractable to existing treatments. Therefore, new therapeutic targets are urgently needed. Human leukocyte antigen-G (HL...
ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study [0.03%]
狼疮患者ICOS基因多态性分析
Hana Houssaini,Emna Bouallegui,Olfa Abida et al.
Hana Houssaini et al.
The inducible T-cell costimulator (ICOS) may play an important role in adaptive immunity by regulating the interaction between T cells and antigen-presenting cells. Disruption of this molecule can lead to autoimmune diseases, in particular ...