The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa [0.03%]
北非现代摩洛哥人中衍生自尼安德特人的LZTFL1位点3p21单体型与COVID-19的严重性相关并进一步提示了尼安德特人在北非的存在
Ahmed Bouhouche,Hanaa Skhoun,Jamila El Baghdadi et al.
Ahmed Bouhouche et al.
There is considerable variability in the clinical presentation of COVID-19 among patients infected with SARS-CoV-2. Genome-wide association studies (GWASs) have identified the 12q24.13 and 3p21.31 regions, derived from Neanderthal DNA, as t...
Wildlife Trade and Genetic Basis of Disease Susceptibility: A Review [0.03%]
野生动物交易与疾病易感性的遗传基础：综述式研究
Oluwakayode Michael Coker,Olukunle Silas Fagbenro,Motunrayo Mojoyin Coker
Oluwakayode Michael Coker
The surge in the trade of wildlife and wildlife products drives several species to extinction while coinciding with the increase in several zoonotic diseases. It is therefore essential to explore the roles of wildlife trade in disease trans...
EXPRESSION OF CONCERN: Association of Polymorphisms in Interleukin-18 and Interleukin-28B With Hepatitis B Recurrence After Liver Transplantation in Chinese Han Population [0.03%]
撤稿声明：白细胞介素-18和白细胞介素-28B多态性与中国汉族肝移植受者乙肝复发的相关性研究
Y. Li, Y. Shi, J. Chen, B. Cai, B. Ying, and L. Wang, "Association of Polymorphisms in Interleukin-18 and Interleukin-28B with Hepatitis B Recurrence after Liver Transplantation in Chinese Han Population," International Journal of Immunogen...
Donor-Derived Cell-Free DNA Levels Predict Renal Allograft Biopsy Findings in a UK Single-Centre Study. Results of the KORAD Study [0.03%]
基于英国单中心研究的移植受者血浆供体来源细胞游离DNA水平预测肾移植病理结果：KORAD研究結果
Patrick A Flynn,Martin K Rutter,Natalia Diaz Burlinson
Patrick A Flynn
Prior studies have shown that donor-derived cell-free DNA (dd-cfDNA) predicts renal biopsy-defined transplant rejection with a high negative predictive value (NPV). However, these studies were not in UK-based cohorts. The KORAD study aimed ...
The Variant rs2706682 at PITPNC1, Which Enhances Vehicular Secretion, Associated With Systemic Lupus Erythematosus Susceptibility in Chinese Populations [0.03%]
中国人群系统性红斑狼疮易感基因PITPNC1位点rs2706682变异与细胞分泌功能增强有关
Ruiying Duan,Yuanyuan Qi,Yangming Zhang et al.
Ruiying Duan et al.
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease in which genetic and environmental factors play important role in SLE pathogenesis. Recently, cytoplasmic phosphatidylinositol transfer protein 1 (PITPNC1) was report...
Recommendations From the Implementation Steering Group for Organ Utilisation Histocompatibility and Immunogenetics Sub-Group: ISOU H&I Sub-Group Recommendations [0.03%]
器官利用组织兼容性和免疫遗传学小组的实施指导委员会推荐意见：ISOU H&I 小组推荐意见
Nicola C Speirs,Victoria Chalker,Brendan Clark et al.
Nicola C Speirs et al.
The Organ Utilisation Group was established to address barriers in solid organ transplantation and improve patient outcomes across the United Kingdom. The group produced a series of recommendations in February 2023. To address these recomme...
Introduction to Pharmacogenomics: Role of the Histocompatibility and Immunogenetics Laboratory in Personalised Medicine-Current Status and Future Prospects [0.03%]
药理基因组学简介：组织相容性和免疫遗传实验室在个性化医疗中的作用-现状和未来前景
William Martin Howell
William Martin Howell
This review provides an introduction to the rapidly expanding field of pharmacogenomics and personalised medicine, with especial relevance and focus for those working in clinical Histocompatibility and Immunogenetics (H&I) laboratories supp...
Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation [0.03%]
不要丢弃脐带血：为什么脐带血仍应是移植治疗的选择之一
Jenna Nunn,Kay Poulton,Robert Wynn
Jenna Nunn
The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances ...
Quantitative Assessment of Analytical Ambiguity in Reverse Sequence-Specific Oligonucleotide (rSSO)-Based HLA Typing Platforms [0.03%]
基于反向序列特异性寡核苷酸(rSSO)的HLA分型平台的分析模糊性定量评估
Fenghua Yuan,Ning Wang,Chao Yuan et al.
Fenghua Yuan et al.
Analytical ambiguity is an inherent and expected feature of reverse sequence-specific oligonucleotide (rSSO)-based HLA genotyping and reflects the size of the candidate allele space compatible with a given probe pattern at the analytical in...
A Simplified, Scalable Solution for Simultaneous Genotyping of Human Leukocyte Antigen Classical Class I and Human Platelet Antigen Genes Utilising Oxford Nanopore Technologies Long-Read Sequencing [0.03%]
一种简化的可扩展解决方案，利用牛津纳米孔技术长读测序同时对人类白细胞抗原经典I类和人血小板抗原基因进行基因分型
Vrushank Makwana,Rohan Raval,Clare Nevin et al.
Vrushank Makwana et al.
Human leucocyte antigen (HLA) class I and human platelet antigens (HPAs) can elicit immune responses, leading to platelet transfusion refractoriness (PTRs). To support the clinical management of patients with PTR, transfusion of HLA class I...