Cellular Morphometric Analysis (CellMorph)-a comprehensive imaging-based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes [0.03%]
基于图像的定量生物异质性和动力学的综合工具CellMorph（细胞形态）
Henrique Quaiato de Oliveira,Solon Andrades da Rosa,Luiza Cherobini Pereira et al.
Henrique Quaiato de Oliveira et al.
Understanding eukaryotic cell morphometry is fundamental to cell biology, as cells exhibit a broad range of sizes and shapes during processes such as senescence, cell death, mitosis, and migration. Dynamic changes in subcellular compartment...
Co-localization of tau and TDP-43 after extracellular vesicle delivery to cells [0.03%]
通过细胞外囊泡递送后tau和TDP-43的共定位
Farhang Aliakbari,Kathryn Volkening,Zahra Nayeri et al.
Farhang Aliakbari et al.
Perturbations in the metabolism of microtubule-associated protein tau (tau) underlie the pathology of a broad array of dementias, including chronic traumatic encephalopathy, amyotrophic lateral sclerosis (ALS) with cognitive impairment (ALS...
Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope-specific immune response [0.03%]
蛋白质纳米颗粒在植物中组装、展示抗原性病毒肽并产生表位特异性免疫反应
Jordan T VanderBurgt,Richard Strasser,Hong Zhu et al.
Jordan T VanderBurgt et al.
Porcine reproductive and respiratory syndrome (PRRS) is one of the major diseases affecting the global swine industry. Current methods to control this viral disease are insufficient or pose safety concerns; therefore, there is a need for a ...
Plasmodium mitochondrial exodeoxyribonucleases, Exomit1 and Exomit2, are conserved within alveolates with Exomit1 essential for the establishment of blood-stage infection [0.03%]
疟原虫线粒体核酸外切酶Exomit1和Exomit2在顶复门生物中保守存在且Exomit1对红内期感染的建立是必需的
Shivani Mishra,Tribeni Chatterjee,Pragya Mehra et al.
Shivani Mishra et al.
The 6-kb linear repeat genome of the mitochondrion (mtDNA) of the malaria parasite is among the smallest known in nature, but is well-conserved in comparison with its apicoplast and nuclear genomes. Except for the presence of base excision ...
Ligand-specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc-containing glycan structures [0.03%]
岩藻糖基化依赖的凝集素CLEC10A信号转导及对树突细胞功能调控的新机制
Nadia L van der Meijs,Remi Hatinguais,Mike de Kok et al.
Nadia L van der Meijs et al.
C-type lectin receptors on dendritic cells shape immune responses to pathogens and tumour cells through the specific recognition of glycans. C-type lectin domain family 10 member A [CLEC10A; also known as Macrophage Galactose-type Lectin (M...
De novo formation of tuft and goblet cells protects the intrapancreatic biliary duct system from inflammatory injury [0.03%]
从头形成绒毛和杯状细胞可保护胰内胆管系统免受炎症损伤
Akifumi Nakagawa,Kate N Von Alt,Mari Mino-Kenudson et al.
Akifumi Nakagawa et al.
The biliary tree is susceptible to inflammatory injury that can result in severe liver damage. However, the intrapancreatic biliary duct system is largely refractory to damage caused by pancreatitis; the mechanisms that protect these ducts ...
Oxygen-independent expression of HIF-1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia [0.03%]
肝癌细胞中细胞周期中的缺氧诱导因子HIF-1α的表达控制着常态下的必需代谢途径
Ioanna-Maria Gkotinakou,Christina Arseni,Kreon Koukoulas et al.
Ioanna-Maria Gkotinakou et al.
Intra-tumoral oxygen deprivation (hypoxia) promotes the activation of hypoxia-inducible factors (HIFs) that orchestrate the transcriptional adaptation of cancer cells to hypoxia. Hypoxia is prevalent in hepatocellular carcinoma (HCC), a can...
Unlocking nitrogen regulation: structural insights into the NifL-NifA complex and prospects for engineered diazotrophs [0.03%]
揭示氮调控机制：NifL-NifA复合物结构洞察及人工固氮菌的前景展望
Edileusa Cristina Marques Gerhardt,Khaled A Selim
Edileusa Cristina Marques Gerhardt
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth-promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, ...
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics [0.03%]
人类NMNAT2的转录调控：来自三维基因组测序和生物信息学的启示
Yu Chen Chang,Sen Yang,Minyoung Cho et al.
Yu Chen Chang et al.
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2) is a crucial enzyme for synthesizing nicotinamide adenine dinucleotide (NAD) and plays a vital role in neuronal health. NMNAT2 mRNA levels correlate positively with c...
Tissue integrity at the root of Metazoa - transcriptional landscape of whole-body regeneration in sponges [0.03%]
动物的组织完整性源于多孔动物的全身再生转录谱系
Nikolai P Melnikov,Kseniia V Skorentseva,Alexander V Ereskovsky et al.
Nikolai P Melnikov et al.
Multicellular animals arose along with complex gene programs controlling tissue integrity. A comprehensive understanding of the core mechanisms underlying tissue maintenance in metazoans requires studying early-branching animal groups. Here...