The ALS-associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle
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DNAJC7, a member of the J-domain protein (JDP/Hsp40) family, plays a key role in protein homeostasis by regulating Hsp70 activity and preventing protein aggregation. Mutations in DNAJC7 have been linked to amyotrophic lateral sclerosis (ALS); yet, the molecula... ...
