Anne-Lise Gérard,Florence Pirard,Caitlin Vanbeek et al.
Anne-Lise Gérard et al.
Devil Facial Tumour Diseases (DFTD), threatening Tasmanian devils, consist of two distinct transmissible cancers, DFT1 and DFT2, with differing origins and geographic spread. We investigated the metabolic differences between DFT1 and DFT2, ...
Redox environment modulates aggregation of ataxin-3 in vitro - Implications for drug screening of cysteine-rich proteins [0.03%]
氧化还原环境调节体外Ataxin-3聚集——关于半胱氨酸丰富型蛋白药物筛选的启示
Martyna Podlasiak,Martina Sollazzo,Elisa Monaca et al.
Martyna Podlasiak et al.
Spinocerebellar ataxia type 3 is a debilitating neurodegenerative disorder driven by the pathological aggregation of ataxin-3 (Atx3), a deubiquitinating enzyme with a cysteine-rich catalytic domain and an expandable polyglutamine (polyQ) tr...
Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation [0.03%]
锁定、放松、装填和射击：Nedd4调控的分子视角
Masa Janosev,Tomas Obsil,Veronika Obsilova
Masa Janosev
The Nedd4 subfamily of HECT E3 ligases is a ubiquitous group of 10 enzymes that share the same domain structure, consisting of a C2 domain, several WW domains and a catalytic HECT domain. Over the past decade, significant progress has been ...
Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease [0.03%]
遗传性先天性红细胞生成障碍性贫血Ⅰ型(CDA-Ⅰ)相关贫血的致病突变会破坏CDIN1-Codanin1复合体
Martin Stojaspal,Tomas Brom,Ivona Nečasová et al.
Martin Stojaspal et al.
Congenital dyserythropoietic anemia type I (CDA-I) is a rare hereditary disease marked by ineffective erythropoiesis, a characteristic spongy heterochromatin structure in erythroblasts, and mutations in the genes CDAN1 and CDIN1, which enco...
ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets [0.03%]
内质网蛋白质稳态与线粒体功能的相互作用：接触位点作为交流枢纽和治疗靶标
Giorgia Maria Renna,Alessandro Cherubini,Ersilia Varone et al.
Giorgia Maria Renna et al.
Proteostasis maintains the balance between protein synthesis, folding, and degradation within the endoplasmic reticulum (ER). This quality-control system ensures that proteins undergo proper post-translational modifications-such as PDI-ERO1...
A supramolecular assembly of cone-specific G-protein and cryptochrome 4a on lipid bilayer [0.03%]
锥体特异性G蛋白和隐花色素4a在脂质双层上的超分子组装体
Ümmügülsüm Güzelsoy-Flügge,Srđan Vujinović,Alexander Scholten et al.
Ümmügülsüm Güzelsoy-Flügge et al.
Signal transduction processes often involve membrane-associated proteins allowing facilitated diffusion of reactive partners in a phospholipid bilayer plane. A benchmark example is phototransduction, taking place at the disk membranes of ve...
Targeting the Notch receptor dimerization domain to inhibit Notch signalling-A new avenue of therapeutics [0.03%]
靶向Notch受体二聚化结构域以抑制Notch信号通路——治疗的新途径
Gerard F Hoyne
Gerard F Hoyne
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to geneti...
Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression [0.03%]
黑素瘤细胞释放的持续表达MHCII类分子的细胞外囊泡促进免疫逃逸和癌症进展
Francesca Costantini,Caterina Di Sano,Samuele Raccosta et al.
Francesca Costantini et al.
The metastatic progression of melanoma, a highly immunogenic cancer, is often associated with constitutive expression of major histocompatibility complex (MHC) class II molecules. Their engagement leads to increased expression and activatio...
Decoding ECM remodeling: proteases as gatekeepers of Lysyl oxidase family-mediated crosslinking [0.03%]
解读ECM重塑：蛋白酶通过调控赖氨酰氧化物家族介导的交联作用发挥守门人的功能
Ashutosh Joshi,Abhi Dutta,Antara Roy et al.
Ashutosh Joshi et al.
Proteases hydrolyze the amide bond of a polypeptide chain, which can influence protein synthesis and function. This activity has been predominantly observed in the post-translational processing of lysyl oxidase (LOX) and lysyl-oxidase-like ...
Identification of Wnt-regulated genes that are repressed by, or independent of, β-catenin [0.03%]
识别由Wnt调节且受β-连环蛋白抑制或不受β-连环蛋白影响的基因
Shiyang Liu,Sara Haghani,Enrico Petretto et al.
Shiyang Liu et al.
Wnt signaling regulates metazoan development and homeostasis, in part by β-catenin-dependent activation and repression of a large number of genes. However, Wnt signaling also regulates genes independent of β-catenin, genes that are less w...