The ribosome-associated complex regulates cytosolic translation upon mitoprotein-induced stress [0.03%]
线粒体蛋白诱导压力下核糖体相关复合物对胞液翻译的调节作用
Jiaxin Qian,Annika Nutz,Katja Hansen et al.
Jiaxin Qian et al.
The biogenesis of mitochondria relies on the import of newly synthesized precursor proteins from the cytosol. Tom70 is a mitochondrial surface receptor which recognizes precursors and serves as an interface between mitochondrial protein imp...
MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria [0.03%]
线粒体抗病毒信号蛋白寡聚化介导的抗病毒信号激活速率和效率优于过氧化物酶体
Bruno Ramos,Jéssica Sarabando,Mariana Marques et al.
Bruno Ramos et al.
Peroxisomes and mitochondria are important platforms for antiviral signal transduction, as detection of cytosolic viral RNA by retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) induces the activation of the mitochondrial antivira...
HnRNPA1 and HuR, but not PTB, modulate cap-independent translation initiation from sense and antisense human T-cell lymphotropic virus type 1 mRNAs [0.03%]
多聚腺苷酸结合蛋白HnRNPA1和HuR调节人类T细胞淋巴瘤病毒Ⅰ型正链和反义mRNA的帽子独立翻译起始，而 polypyrimidine tract-binding 蛋白则没有此功能
Brenda López-Ulloa,Dafne Mendonça,Daniela Guzmán-Correa et al.
Brenda López-Ulloa et al.
The human T-cell lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis. HTLV-1 transcribes sense and two antisense messenger RNAs (mRNAs). The spliced and unspliced antis...
Histone demethylases regulate ferroptosis in metabolic dysfunction-associated steatotic liver disease via epigenetic modification [0.03%]
组蛋白去甲基化酶通过表观遗传修饰调控代谢紊乱相关性脂肪肝病中铁死亡发生的机制研究
Wentao Huang,Wanqiu Wu,Jiaqi Xiao et al.
Wentao Huang et al.
Ferroptosis, an iron-dependent, non-apoptotic form of cell death, is characterised by pathogenic lipid reactive oxygen species accumulation, dysregulated iron homeostasis, and oxidative stress-induced membrane damage. Numerous studies have ...
Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro [0.03%]
人 Pentraxin 相关蛋白 PTX3 通过促进摄噬作用消除铁死亡的肺泡上皮细胞从而减轻爆炸引起的急性肺损伤（体外模型）
Chang-Mei Weng,Jian-Yi Kang,Zhao-Xia Duan et al.
Chang-Mei Weng et al.
Blast injuries are common in both peacetime and war, and one of the main types is lung injury, characterised by internal severity, rapid changes in condition, high mortality, and complex injury patterns. The primary pathological manifestati...
Plant organelle C-to-U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis [0.03%]
植物细胞器C到U的RNA编辑因子可以在酵母（ Saccharomyces cerevisae ）中成功运行，从而成为研究这些因子功能的易于操作的真核模式生物系统
Shyam Ramanathan,Annika Hanraths,Jingchan Xie et al.
Shyam Ramanathan et al.
Site-specific cytidine-to-uridine (C-to-U) RNA editing is essential for gene expression in plant mitochondria and chloroplasts. Specific RNA-binding pentatricopeptide repeat (PPR) proteins equipped with a DYW-type cytidine deaminase have be...
Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation, and transcriptional regulation as human S100 proteins [0.03%]
硬骨鱼特有的ictacalcin具有与人类S100蛋白类似的结构组成、阳离子依赖性激活和转录调控
Liz Hernández,Théo Paris,Maria Demou et al.
Liz Hernández et al.
S100 proteins are highly versatile calcium-binding proteins from vertebrates. Following extracellular release, they become essential in immune and antimicrobial defenses, initiating the inflammatory response through receptor signaling and p...
High levels of serum cholesterol increase the risk of developing vessel co-opting tumors in colorectal cancer liver metastases [0.03%]
高水平的血清胆固醇会增加结直肠癌肝转移瘤血管征的风险
Amatzia Gantz,Audrey Kapelanski-Lamoureux,Miran Rada et al.
Amatzia Gantz et al.
Cholesterol availability has been implicated in cancer progression. Here, we demonstrate the connection between blood cholesterol concentration, the development of distinct histopathological growth patterns (HGPs) in colorectal cancer liver...
The antihypertensive agent ACT-132577 alleviates cuproptosis and pressure-overload-induced vascular remodelling by modulation of the NEDD4-LCTR1-copper signaling [0.03%]
抗高血压药物ACT-132577通过调节NEDD4-LCTR1-铜信号通路缓解血管重塑及铜依赖性细胞死亡（杯伏托斯）
Rui Qiang Qi,Yu Fei Chen,Xiao-Yan Yang et al.
Rui Qiang Qi et al.
ACT-132577 is a newly approved anti-hypertensive agent in the treatment of hypertension and related cardiovascular diseases. However, its exact roles and underlying mechanisms beyond simple blood pressure regulation remain largely unclear. ...
Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer [0.03%]
基质金属蛋白酶MMP-2和MMP-9的抑制剂治疗乳腺癌的潜能研究
Alireza Shoari,Mathew A Coban,Evette S Radisky
Alireza Shoari
Matrix metalloproteinases (MMPs) are secreted and cell membrane-associated enzymes that remodel the extracellular matrix (ECM) and cleave extracellular proteins to promote tumor invasion, angiogenesis, immune evasion, and many other aspects...