Redox environment modulates aggregation of ataxin-3 in vitro - Implications for drug screening of cysteine-rich proteins
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Spinocerebellar ataxia type 3 is a debilitating neurodegenerative disorder driven by the pathological aggregation of ataxin-3 (Atx3), a deubiquitinating enzyme with a cysteine-rich catalytic domain and an expandable polyglutamine (polyQ) tract. While the role ... ...
