USP8-EIF2S1 signaling enhances CML cell survival under TKI-induced stress [0.03%]
USP8-EIF2S1信号通路可增强TKI诱导的压力下CML细胞的存活率
Chethampadi Gopi Mohan,Keechilat Pavithran
Chethampadi Gopi Mohan
CML is primarily driven by the oncogenic BCR-ABL fusion kinase; however, tyrosine kinase inhibitor (TKI) resistance remains a significant clinical challenge. A study by Zang et al. identified USP8 as a critical mediator of this resistance. ...
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans that is alleviated by sugar supplementation [0.03%]
肠道细菌的色氨酸代谢会导致秀丽隐杆线虫毒性并可通过补充糖分缓解
Shivani Gahlot,Subodh,Jogender Singh
Shivani Gahlot
Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nicotinamide. Although dietary tryptophan is...
Impaired postsynaptic function and disruption of intermediate filaments in GLAST-knockout-induced hidden hearing loss [0.03%]
GLAST敲除小鼠隐性听力损失的突触后功能障碍和中间丝紊乱
Kefeng Ma,Fenghan Wang,Xiaoqiong Song et al.
Kefeng Ma et al.
Hidden hearing loss (HHL) is an inner ear disorder that is characterized by synaptopathy despite normal hearing thresholds. In HHL mouse models, synaptopathy and decreased wave I amplitude were the key pathological and auditory features. Ho...
Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases [0.03%]
由真菌型III聚酮合酶催化生物活性喹诺酮类和（硫）香豆素类化合物的生物合成
Nika Sokolova,Angelina Osipyan,Lili Zhang et al.
Nika Sokolova et al.
Quinolones are privileged scaffolds for drug discovery that are relatively rare in nature. Here, we characterise two promiscuous fungal polyketide synthases AthePKS and FerePKS, which we had previously found to produce 2-quinolones in vitro...
Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression [0.03%]
缺氧通过改变染色质可接近性和基因表达调节Th17/Treg平衡
Mariana Cázares-Olivera,Shiyang Song,Sofia Ylinen et al.
Mariana Cázares-Olivera et al.
Hypoxia plays an important role in multiple biological processes, including inflammation, and modulates the T helper 17 (Th17) and regulatory T-cell (Treg) imbalance that often contributes to inflammatory diseases. Although the transcriptio...
Kinetic and molecular modelling analyses of butyrylcholinesterase activity toward 'inverse' substrates [0.03%]
动力学和分子建模分析乙酰胆碱酯酶对“逆”底物的作用
Anastasia R Blinova,Zukhra Shaihutdinova,Eldar Biktibaev et al.
Anastasia R Blinova et al.
The high catalytic power of cholinesterases results from an efficient interplay between optimised structure, molecular dynamics and fine adjustment of substrates in the active site. Kinetic and molecular modelling investigations of the cata...
LAT1/SLC7A5-mediated amino acid uptake is regulated by redox signals triggered by formyl-peptide receptor 2 [0.03%]
形式肽受体2触发的氧化还原信号调节LAT1/SLC7A5介导的氨基酸摄取
Myrhiam Cassese,Chiara Brignola,Stefano Marrone et al.
Myrhiam Cassese et al.
The rewiring of amino acid (AA) metabolism is a key characteristic of cancer metabolism. Cells can only synthesize nonessential AAs, but if the demands of highly proliferating cells don't meet the endogenous synthesis capacity, AAs must be ...
Mechanism for synthesis of isomaltooligosaccharides from maltooligosaccharides by GH15 α-glucan 4(6)-α-glucosyltransferase [0.03%]
GH15 α-葡萄糖苷酶4(6)-α-葡萄糖基转移酶催化麦芽低聚糖异构化合成异麦芽低聚糖的机制研究
Tianyi Qin,Wataru Saburi,Momo Sawada Otsubo et al.
Tianyi Qin et al.
Isomaltosaccharides, composed of α-(1 → 6)-d-glucosyl residues, exhibit diverse beneficial properties depending on the degree of polymerization (DP) and attract great interest across multiple industries. The anomer-retaining transglucosid...
Tomas Sinkunas,Giedre Tamulaitiene
Tomas Sinkunas
Anti-CRISPR (Acr) proteins are small protein inhibitors that block the RNA-guided nucleic acid (DNA or RNA) targeting activity of CRISPR-Cas enzymes. Despite their shared function, Acr proteins display minimal sequence or structural similar...
Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids [0.03%]
家族性突变调节α-突触核蛋白与关键神经膜脂质的相互作用
Abid Ali,Mikhail Matveyenka,Dmitry Kurouski
Abid Ali
Progressive aggregation of α-synuclein (α-Syn) in the midbrain, hypothalamus and thalamus is linked to Parkinson's disease (PD), one of the fastest growing neurodegenerative diseases in the U.S. Studies of families with PD history reveale...