Sylvie Ricard-Blum,Julie Fradette
Sylvie Ricard-Blum
Extracellular matrix (ECM) proteins, known as the matrisome, have long been recognized for their structural roles and their control of cell phenotypes in health and disease. The broad range of biological activities mediated by the ECM has b...
Comparative evaluation of noncanonical amino acids as site-specific NMR probes for the complex of E. coli SSB with single-stranded DNA without isotope labelling [0.03%]
不经同位素标记测定非 canonical 氨基酸作为报告基因监测大肠杆菌SSB与单链DNA形成的复合物的适用性
Sreelakshmi Mekkattu Tharayil,Haocheng Qianzhu,Elwy H Abdelkader et al.
Sreelakshmi Mekkattu Tharayil et al.
The binding of tetrameric E. coli single-stranded DNA-binding protein (SSB) to single-stranded DNA (ssDNA) was investigated using genetically encoded noncanonical amino acids (ncAA) as site-specific probes for detection by nuclear magnetic ...
Uncovering a previously unknown function of polyphosphate in polyadenylated RNA-induced amyloidogenesis of Hfq [0.03%]
揭示多磷酸盐在多腺苷酸化RNA诱导的Hfq淀粉样变性中的未知功能
Kevin Mosca,Florian Turbant,Sambhasan Banerjee et al.
Kevin Mosca et al.
Polyphosphate (polyP), a ubiquitous and highly conserved biopolymer, has emerged as a potential modulator of bacterial amyloidogenesis. In bacteria, polyP contributes to the formation of dense intracellular regions associated with transcrip...
Anti-cancer drugs targeting the NADH-binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity [0.03%]
靶向VDAC的NADH结合位点的抗肿瘤药物重新布线通道电生理学并部分抑制阳离子选择性
Stefano Conti-Nibali,Giuseppe Battiato,Salvatore Antonio Maria Cubisino et al.
Stefano Conti-Nibali et al.
Located at the crossroads between mitochondria and cytosol, VDAC1 (Voltage-Dependent Anion Selective Channel isoform 1) serves as the chief actor in the regulation of cell metabolism and apoptosis. The crucial role in cell fate determinatio...
Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism [0.03%]
能量压力与脂肪酸氧化障碍联合诱导辅酶A滞留并适应辅酶A代谢
Ligia Akemi Kiyuna,Christoff Odendaal,Madhulika Singh et al.
Ligia Akemi Kiyuna et al.
Coenzyme A (CoA) is a vital cofactor involved in 8-10% of all metabolic reactions in human cells. Different inherited enzyme deficiencies in which the oxidation of acyl-CoAs is hampered have been hypothesised to share a phenotype characteri...
Biochemical characterization and mutational analysis of the tetrameric DABA transaminase EctB from the Arctic bacterium Marinobacter sp. CK1 [0.03%]
来自北极细菌Marinobacter sp. CK1四聚体DABA转氨酶EctB的生化表征和突变分析
Amalie C A Skogvold,Ingar Leiros,Richard A Engh et al.
Amalie C A Skogvold et al.
Ectoine is a chemical chaperone and osmoprotectant discovered in halophilic bacteria where it is used to protect from osmotic stress in high-salt environments. Ectoine has become a valuable product in pharmaceutical, biotechnological, cosme...
Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins [0.03%]
利用模式生物酿酒酵母Saccharomyces cerevisiae开展五肽重复蛋白研究及应用探索
Farley M Kwok van der Giezen,Ian Small
Farley M Kwok van der Giezen
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et a...
The competitive interplay of 12-oxophytodienoic acid (OPDA), protein thiols, and glutathione [0.03%]
12-氧植物二烯酸（OPDA）、蛋白质巯基和谷胱甘肽之间的竞争相互作用
Madita Knieper,Ruben Schwarz,Lara Vogelsang et al.
Madita Knieper et al.
Cis-(+)-12-oxophytodienoic acid (OPDA) is a bioactive oxylipin and phytohormone participating in regulation of plant stress responses, growth, and development. Due to its α, β-unsaturated carbonyl moiety, OPDA covalently binds to free thi...
Niall S Kenneth,Michael Batie,Sonia Rocha
Niall S Kenneth
Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies worldwide, largely due to late diagnosis and limited therapeutic options. Tumor hypoxia is a hallmark of HCC and drives aggressive disease behavior, in part through ...
Yara Nabawi,Cansu Doğan,Dunja Petrović et al.
Yara Nabawi et al.
To maintain proteome integrity within distinct subcellular compartments, cells rely on tightly regulated proteostasis mechanisms, including protein synthesis, folding, trafficking, and degradation. Disruption of these processes leads to the...