Plant organelle C-to-U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis [0.03%]
植物细胞器C到U的RNA编辑因子可以在酵母（ Saccharomyces cerevisae ）中成功运行，从而成为研究这些因子功能的易于操作的真核模式生物系统
Shyam Ramanathan,Annika Hanraths,Jingchan Xie et al.
Shyam Ramanathan et al.
Site-specific cytidine-to-uridine (C-to-U) RNA editing is essential for gene expression in plant mitochondria and chloroplasts. Specific RNA-binding pentatricopeptide repeat (PPR) proteins equipped with a DYW-type cytidine deaminase have be...
Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation, and transcriptional regulation as human S100 proteins [0.03%]
硬骨鱼特有的ictacalcin具有与人类S100蛋白类似的结构组成、阳离子依赖性激活和转录调控
Liz Hernández,Théo Paris,Maria Demou et al.
Liz Hernández et al.
S100 proteins are highly versatile calcium-binding proteins from vertebrates. Following extracellular release, they become essential in immune and antimicrobial defenses, initiating the inflammatory response through receptor signaling and p...
High levels of serum cholesterol increase the risk of developing vessel co-opting tumors in colorectal cancer liver metastases [0.03%]
高水平的血清胆固醇会增加结直肠癌肝转移瘤血管征的风险
Amatzia Gantz,Audrey Kapelanski-Lamoureux,Miran Rada et al.
Amatzia Gantz et al.
Cholesterol availability has been implicated in cancer progression. Here, we demonstrate the connection between blood cholesterol concentration, the development of distinct histopathological growth patterns (HGPs) in colorectal cancer liver...
The antihypertensive agent ACT-132577 alleviates cuproptosis and pressure-overload-induced vascular remodelling by modulation of the NEDD4-LCTR1-copper signaling [0.03%]
抗高血压药物ACT-132577通过调节NEDD4-LCTR1-铜信号通路缓解血管重塑及铜依赖性细胞死亡（杯伏托斯）
Rui Qiang Qi,Yu Fei Chen,Xiao-Yan Yang et al.
Rui Qiang Qi et al.
ACT-132577 is a newly approved anti-hypertensive agent in the treatment of hypertension and related cardiovascular diseases. However, its exact roles and underlying mechanisms beyond simple blood pressure regulation remain largely unclear. ...
Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer [0.03%]
基质金属蛋白酶MMP-2和MMP-9的抑制剂治疗乳腺癌的潜能研究
Alireza Shoari,Mathew A Coban,Evette S Radisky
Alireza Shoari
Matrix metalloproteinases (MMPs) are secreted and cell membrane-associated enzymes that remodel the extracellular matrix (ECM) and cleave extracellular proteins to promote tumor invasion, angiogenesis, immune evasion, and many other aspects...
PEMT-mediated phospholipid imbalance promotes age-associated metabolic dysfunction-associated steatotic liver disease progression [0.03%]
PEMT介导的磷脂失衡促进衰老相关的代谢功能异常性脂肪肝病进展
Xilong Gao,Jiahui Gong,Yichao Hou et al.
Xilong Gao et al.
Metabolic dysfunction-associated steatotic liver disease [MASLD; previously known as nonalcoholic fatty liver disease (NAFLD)] is a prevalent chronic liver disorder strongly associated with aging, yet the mechanisms underlying age-related h...
LC3-positive extracellular vesicles released from tumor cells promote lung metastasis of breast cancer by inducing vascular permeability [0.03%]
乳腺癌细胞释放的LC3阳性胞外囊泡通过诱导血管通透性促进肺转移
Yuqing Shen,Yi Shen,Xuru Wang et al.
Yuqing Shen et al.
Tight junctions (TJs) between pulmonary vascular endothelial cells (ECs) constitute the physical barrier that impedes the metastasis of tumor cells. We previously reported that circulating microtubule-associated proteins 1A/1B light chain 3...
Understanding the catalytic mechanism of the triazine hydrolase from Arthrobacter aurescens TC1 [0.03%]
铜绿假单胞菌TC1三嗪水解酶的催化机制研究
Maya Mowery-Evans,Grayson Gerlich,Karla Diviesti et al.
Maya Mowery-Evans et al.
The catalytic mechanism of the Zn(II)-dependent triazine hydrolase (TrzN) from Arthrobacter aurescens TC1 was examined by measuring the pH dependence of the Michaelis constants kcat, Km, and kcat/Km, the solvent isotope effect, and the ther...
A comprehensive overview of yeast libraries and their role in advancing cell biology [0.03%]
酵母库的全面概述及其在细胞生物学中的作用
Din Baruch,Maya Schuldiner,Ofir Klein
Din Baruch
Over the past two decades, genome-wide collections of mutants, or libraries, have revolutionized the fields of systems and cell biology by enabling systematic and high-throughput interrogation of gene and protein function. This has been esp...
SARS-CoV-2 nucleocapsid protein variants have differential RNA chaperone activity [0.03%]
SARS-CoV-2核衣壳蛋白变异体具有不同的RNA分子伴侣活性
Sabrina Babl,Julia M Seidel,Fabian Kugler et al.
Sabrina Babl et al.
The single-stranded RNA genome of the SARS-CoV-2 virus is characterized by a complex secondary structure formed by patches of intramolecular RNA double-strands. Here, we show that the nucleocapsid (N) protein is not only the specific viral ...