TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle [0.03%]
TEAD4调节小鼠着床前胚胎中的KRT8和YAP，但不在牛中调节它们
Xiaotong Wu,Yan Shi,Bingjie Hu et al.
Xiaotong Wu et al.
In brief: Lineage specification plays a vital role in preimplantation development. TEAD4 is an essential transcription factor for trophectoderm lineage specification in mice but not in cattle. ...
Investigating ticagrelor in a preclinical pipeline as a novel therapeutic to prevent preterm birth [0.03%]
在临床前的研究流程中调查替卡格雷作为一种新型疗法以预防早产的可能性
Bridget M Arman,Natalie K Binder,Natasha de Alwis et al.
Bridget M Arman et al.
In brief: Preterm birth is the leading cause of perinatal morbidity and mortality, and new therapies that delay preterm birth and improve neonatal outcomes are urgently needed. This study investigates whether ticagrelor i...
Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos? [0.03%]
TFAP2C决定小鼠着床前胚胎的矛盾细胞命运吗？
Chad S Driscoll,Jaehwan Kim,Mohamed Ashry et al.
Chad S Driscoll et al.
Transcription factor AP2 gamma (TFAP2C) is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here, we hypothesize and provid...
Oocyte activation is a cytoplasm-confined event so far: what about the nucleus? [0.03%]
卵母细胞活化目前仅局限于胞质中进行：那么核会怎样呢？
Luisa Gioia,Luca Palazzese,Marta Czernik et al.
Luisa Gioia et al.
The fertilizing spermatozoa induce a Ca2+ oscillatory pattern, the universal hallmark of oocyte activation, in all sexually reproducing animals. Assisted reproductive technologies (ARTs) like intracytoplasmic sperm injection (ICSI) bypass t...
Generation of porcine endometrial organoids and their use as a model for enhancing embryonic attachment and elongation [0.03%]
猪子宫内膜类器官的生成及其在增强胚胎着床和伸长中的应用模型研究
Islam M Saadeldin,Ayeong Han,Seonggyu Bang et al.
Islam M Saadeldin et al.
In brief: Porcine endometrial organoids (EOs) were isolated and characterized, revealing distinctive features such as unique extracellular matrix formation, fusion into uterine bud-like structures, and facilitation of emb...
Immunohistochemical examination of the utero-placental interface of cows on days 21, 31, 40, and 67 of gestation [0.03%]
妊娠21、31、40和67天子宫胎盘界面的免疫组织化学观察
Heewon Seo,Gabriela D Melo,Ramiro V Oliveira et al.
Heewon Seo et al.
What we understand about early stages of placentation in cattle is based on an elegant series of electron microscopic images that provide exquisite detail, but limited appreciation for the microanatomy across the utero-placental interface. ...
MicroRNA-146b negatively affects bovine embryo development and quality [0.03%]
微小核糖核酸-146b通过靶向作用于STAT3负向调控牛胚胎发育和质量
Krishna Chaitanya Pavani,Guan XueFeng,Jayendra Chunduru et al.
Krishna Chaitanya Pavani et al.
MicroRNAs (miRNAs), which can be carried inside extracellular vesicles (EVs), play a crucial role in regulating embryo development up to the blastocyst stage. Yet, the molecular mechanisms underlying blastocyst development and quality are l...
Spermatogonial depletion and a spermatogenesis defect in the Dp(16)1Yey mouse model of Down syndrome [0.03%]
道尔顿综合症鼠模型中精原细胞耗竭及精子发生缺陷
Rodolphe Dard,Anastasia Tutunaru,Malek Bouassida et al.
Rodolphe Dard et al.
Down syndrome (DS), or Trisomy 21, is the most common chromosomal disorder in humans. Men with DS are infertile. The DYRK1A gene on Hsa21 is involved in several features of DS. Overexpression of the homolog dyrk1A disrupts primordial germ c...
In vitro reduction of bovine oocyte ATP production with oligomycin affects embryo epigenome [0.03%]
卵子ATP生成减少影响胚胎表观基因组
Ben Meulders,Jo L M R Leroy,Inne Xhonneux et al.
Ben Meulders et al.
In brief: Epigenetic programming is a crucial process during early embryo development that can have a significant impact on the results of assisted reproductive technology (ART) and offspring health. Here we show evidence...
Ca2+ concentrations in mouse sperm mitochondria fluctuate according to the cytosol [0.03%]
小鼠精子线粒体中的Ca2+浓度随细胞质波动而变化
Yoloxochitl Sánchez-Guevara,Enrique I Oliver,Takuya Nishigaki
Yoloxochitl Sánchez-Guevara
Mitochondria are important organelles in eukaryotic cells and play an essential role in energy production and cell signaling. However, the importance of mammalian sperm mitochondria as an energy source remains to be elucidated because glyco...