Mechanisms of non-obstructive azoospermia caused by TOP6BL variants [0.03%]
由TOP6BL突变引起的非梗阻性无精子症的机制研究
Chao Wang,Yanwei Sha,Yayun Ji et al.
Chao Wang et al.
In brief: Non-obstructive azoospermia (NOA) is a major cause of male infertility, with many cases having unknown origins. This study identifies two TOP6BL variants linked to NOA, revealing their impact on meiotic DNA doub...
Deconvoluting the heterogeneities of immune cells at the maternal-fetal interface of mice across pregnancy [0.03%]
小鼠孕期母胎界面免疫细胞异质性的分层解析
Jingjing Su,Yue Wang,Qian Li et al.
Jingjing Su et al.
In brief: Mice often serve as valuable surrogate models for studying human reproduction. This study provides a single-cell transcriptomic profile of mouse immune cells at the maternal-fetal interface throughout pregnancy ...
Identification of transcriptome markers in blue catfish cryopreserved sperm to predict male reproductive performance [0.03%]
用于预测蓝猫鱼性生殖能力的转录组标志物的鉴定
Ying Zhang,Kyle R Wood,Thu M Dunkleberger et al.
Ying Zhang et al.
In brief: This study establishes a mechanistic link between sperm-specific transcriptomic profiles and hatch success, demonstrating that a six-gene panel can serve as a statistically robust predictor of hatch success in h...
ZDHHC5 deficiency impairs spermatogenesis and causes male infertility in mice [0.03%]
ZDHHC5缺乏通过损害精子发生导致小鼠雄性不育
Zerui Wang,Yueming Li,Shuya Sun et al.
Zerui Wang et al.
In brief: S-palmitoylation is a key protein modification, but the role of ZDHHC5 in male fertility was unknown. This study shows ZDHHC5 loss impairs spermatogenesis, causing male infertility, and identifies ZDHHC5 as a ke...
Inhibition of fatty acid amide hydrolase leads to uterine vascular defects and decreased fertility in pregnant rats [0.03%]
脂肪酸酰胺水解酶抑制导致怀孕大鼠子宫血管缺陷和生育率下降
Vanesa A Cañumil,Fernanda L de la Cruz Borthiry,Frida Scheffer et al.
Vanesa A Cañumil et al.
In brief: Dysregulation in anandamide homeostasis induces defects in the vascular adaptations of the uterus that threaten the continuity of pregnancy. We provide new evidence about the role of anandamide as a mediator in ...
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: PCOS in adolescents: ontogeny of neuroendocrine and metabolic disturbances [0.03%]
多囊卵巢综合征：起源及其影响：青春期多囊卵巢综合征：神经内分泌和代谢紊乱的发育起源
Hala Tfayli,Silva Arslanian,Selma Feldman Witchel
Hala Tfayli
In brief: Early clinical manifestations of PCOS may begin during puberty. This paper reviews the initial characteristics of PCOS in the adolescent girl. A...
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Maternal complications of pregnancy in polycystic ovary syndrome [0.03%]
多囊卵巢综合征：起源及影响：多囊卵巢综合征的妊娠母体并发症
Andrea K Wegrzynowicz,Christina M Dudley,Laura G Cooney et al.
Andrea K Wegrzynowicz et al.
In brief: PCOS leads to an increased risk of pregnancy complications, and immunological factors are strongly implicated in both PCOS and pregnancy complications. This review discusses the leading theories for this connect...
FGF receptor 2 signaling in granulosa cells is required for normal female fertility in mice [0.03%]
FGF受体2信号通路在颗粒细胞中对小鼠正常雌性生育力是必需的
Takuya Kanke,Ayaka Ichikawa,Yuki Akimoto et al.
Takuya Kanke et al.
In brief: Fibroblast growth factor (FGF) signaling has been implicated in ovarian follicular development in mammals, but its in vivo role in female fertility remains unclear. This study reveals the requirement of fibrobla...
Differential hypothalamic regulation of FSH and LH secretion from the fish pituitary by GnRH and CCK [0.03%]
GnRH和CCK通过不同途径调节鱼类垂体FSH和LH的分泌
Naama Mizrahi,Miriam Shulman,Tomer Aiznkot et al.
Naama Mizrahi et al.
In brief: The hypothalamus-pituitary-gonad axis integrates environmental and internal signals to tune reproductive functions. We hypothesized that in fish, Gnrh predominantly stimulates luteinizing hormone (LH) secretion,...
mTORC1-dependent suppression of autophagic activity in somatic cell nuclear transfer mouse embryos [0.03%]
mTORC1依赖性抑制体细胞核移植胚胎自噬活性
Takaki Tatebe,Dinh Quoc Pham,Atsuo Ogura et al.
Takaki Tatebe et al.
In brief: The non-genomic factors responsible for developmental arrest in SCNT embryos remain poorly understood. Using live-cell fluorescence imaging, we revealed that autophagic activity is impaired in preimplantation SC...