Spermatogonial depletion and a spermatogenesis defect in the Dp(16)1Yey mouse model of Down syndrome
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Down syndrome (DS), or Trisomy 21, is the most common chromosomal disorder in humans. Men with DS are infertile. The DYRK1A gene on Hsa21 is involved in several features of DS. Overexpression of the homolog dyrk1A disrupts primordial germ cell migration in zeb... ...
