Development and Validation of a Manganese-metabolism and Immune-integrated Gene Signature for Prognosis and Immune Contexture in Patients with Colorectal Cancer [0.03%]
用于结直肠癌预后和免疫微环境的锰代谢和免疫整合基因特征的开发与验证
Lei He,Zhengxin Chen,Chang Zhang et al.
Lei He et al.
Colorectal cancer (CRC) is the third most frequently diagnosed cancer and the second leading cause of cancer-related mortality globally. Emerging evidence identifies manganese as an important trigger for the cyclic GMP-AMP synthase (cGAS)-s...
Molecular Mechanisms of Pulmonary Fibrosis: The Interaction of Epithelial-mesenchymal Transition and AMPK Pathways in a Bleomycin-induced Model [0.03%]
肺纤维化的分子机制：BLM诱导模型上上皮间质转化与AMPK通路的交互作用
Omid Sadatpour,Hoda Kavosi,Mahdi Mahmoudi et al.
Omid Sadatpour et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive extracellular matrix (ECM) deposition, largely mediated by activated fibroblasts. Epithelial-mesenchymal transition (EMT), regulated by transcription fact...
Evaluation of the Effects of Newcastle Disease Virus as an Oncolytic Virus on the Expression of Apoptosis-related Genes in TC-1 Cell Line [0.03%]
新城疫病毒溶瘤作用对TC-1细胞系凋亡相关基因表达的影响研究
Mohammad Ali Akbar Esfahani,Ruhollah Dorostkar,Hadi Esmaeili Gouvarchin Ghaleh et al.
Mohammad Ali Akbar Esfahani et al.
TC-1 is a recognized cancer cell line derived from lung epithelial cells that have been altered using the oncogenic E6 and E7 genes of human papillomavirus (HPV). These TC-1 cells are frequently utilized in preclinical research focused on l...
TREM1 Enhances Macrophage Proinflammatory Response to LPS by Promoting NF-κB Activation via an IL-26-mediated JAK/STAT Signaling Pathway [0.03%]
TREM1通过IL-26介导的JAK/STAT信号通路促进NF-κB活化从而增强LPS诱导的巨噬细胞炎症反应
Liangliang Xie,Fei Gao,Jianmin Xu et al.
Liangliang Xie et al.
Lipopolysaccharide (LPS)-induced inflammation in macrophages involves complex signaling pathways. This investigation explored the regulatory roles of triggering receptor expressed on myeloid cells-1 (TREM1) and interleukin (IL)-26 in the Ja...
In vitro Safety and Immunotoxicity Assessment of a Novel mRNA-LNP Vaccine against Cytomegalovirus: Insights into Safety and Immunomodulatory Profiles [0.03%]
一种新型巨细胞病毒mRNA-LNP疫苗的体外安全性与免疫毒性评估：安全性和免疫调节特性分析
Somayeh Mami,Sajjad Shekarchian,Alireza Naderi Sohi et al.
Somayeh Mami et al.
Predominantly a widespread beta herpesvirus, human cytomegalovirus (HCMV) triggers lifelong latent infection in most of the people, and HCMV vaccine development has been designated a high public health priority. In the current study, the in...
Investigating the Interplay between the Gut Microbiota and Host Immunity in Gastroenteric Disorders: The Potential of Combined Drug Therapies to Restore Microbial-immune Homeostasis [0.03%]
探究肠道微生物与宿主免疫在胃肠疾病中的相互作用：联合药物治疗恢复微生态-免疫平衡的潜能
Yanlin Qiao,Xiang Gao
Yanlin Qiao
This study examines the interaction between the microbiota and the immune system in diseases of the gastrointestinal tract, with a special emphasis on the synergistic use of pharmacological agents. This was a retrospective, observational st...
Evaluation of Salivary sIgA Levels in Hospitalized COVID-19 Patients with COVID-19 Disease Severity: A Cross-sectional Study [0.03%]
评估住院COVID-19患者疾病严重程度的唾液sIgA水平：一项横断面研究
Zahra Valizadeh,Sara Ghaderkhani,Sahereh Eshraghi et al.
Zahra Valizadeh et al.
Since late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) pandemic has dramatically affected public health worldwide. Although systemic antibodies like Immunoglobulin G (IgG) and Immunoglobulin M (IgM)have been wid...
Correlation between Component-resolved Diagnostics (CRD) and Clinical Symptoms in Allergic Children: A One-year Study at the Children's Medical Center (April 2023-March 2024) [0.03%]
儿童组分诊断(CRD)与临床症状相关性研究（2023年4月-2024年3月）——以某儿童医院为例
Maedeh Khoshkam,Mahshid Movahedi,Mohammad Gharagozlou et al.
Maedeh Khoshkam et al.
Component- Resolved Diagnosis (CRD) is an effective tool in allergy diagnosis, that detects specific IgE to allergenic molecules. The ALEX (Allergy Explorer) test, commercially available since 2019, measures specific IgE to allergenic extra...
miR-10a Delivered via MSC-derived Extracellular Vesicles Modulates Inflammation in a CCl4-induced Liver Fibrosis Model [0.03%]
MSC源性外泌体递送的miR-10a调节四氯化碳致小鼠肝纤维化炎症反应的作用及机制研究
Liang Wang,Youjia Ni
Liang Wang
Liver fibrosis is a significant global health issue characterized by an abnormal accumulation of extracellular matrix proteins, that disrupts normal liver architecture and function. Mesenchymal stem cells (MSCs) show therapeutic potential b...
A Mendelian Randomization Study of Cardiovascular Proteins, Immune Cell Traits, and Lifestyle Factors [0.03%]
心血管蛋白、免疫细胞特征和生活方式因素的孟德尔随机化研究
Hui Deng,Qing Wang,Yuming Wang et al.
Hui Deng et al.
We aimed to investigate the causal relationship between cardiovascular-related proteins and osteoporosis and to assess the influence of immune cell traits and lifestyle factors such as smoking and alcohol consumption on osteoporosis risk. A...