Molecular mechanisms of FSP1-regulated ferroptosis and therapeutic implications in various cancers [0.03%]
FSP1调控铁死亡的分子机制及其在各种癌症治疗中的意义研究
Congyue Zhang,Chao Sun,Yuemin Nan
Congyue Zhang
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. In addition to the canonical glutathione peroxidase 4 pathway, ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mito...
IL17 signaling promotes oocyte developmental competence acquisition during maturation [0.03%]
白细胞介素17信号通过促进卵母细胞成熟过程中获得发育潜能来提高胚胎质量
Huaxing Zhao,Xiaohua He,Junsong Shi et al.
Huaxing Zhao et al.
Background: Defects in the acquisition of oocyte developmental competence during the maturation process causes subfertility or infertility in animals and humans. Understanding the regulatory mechanisms of oocyte maturatio...
TREM-1-dependent macrophage infiltration mediates visceral hypersensitivity via vlPAG GABAergic neuron activation in a mouse model of inflammatory bowel disease [0.03%]
TREM-1依赖的巨噬细胞浸润通过炎症性肠病小鼠模型中vlPAG胆碱能神经元活化介导内脏高敏感性
Zi-Ming Zhou,Wei Song,Miao-Miao Guo et al.
Zi-Ming Zhou et al.
Background: Visceral pain is a common symptom of inflammatory bowel disease (IBD). Although triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to induce infiltration of peripheral immune cells into t...
PRKN mediates the ubiquitination of SCAF8 to reduce the mRNA stability of KLF5 and its transcriptional activation of EFNA3 in colorectal cancer [0.03%]
PRKN通过介导SCAF8的泛素化降低KLF5 mRNA稳定性及其对EFNA3转录激活作用在结直肠癌中的研究
Ye Song,Yangsheng Yu,Bo Zhang et al.
Ye Song et al.
Background: Dysregulation in glycolysis within the tumor microenvironment is a hallmark in the context of colorectal cancer (CRC). We aimed to identify critical drivers of glycolysis in CRC and decipher the underlying mec...
Biased signaling of β2-adrenergic receptor in physiological and pathological states [0.03%]
β2-肾上腺素能受体在生理和病理状态下的偏向性信号转导
Yaxin Xu,Vincent Kawuribi,Joseph Adu-Amankwaah et al.
Yaxin Xu et al.
The β2-adrenergic receptor (β2AR), a pivotal member of the G protein-coupled receptor (GPCR) family, plays a crucial role in cellular signaling and is extensively involved in many physiological and pathological processes. Unlike the class...
α-tubulin N-acetyltransferase 1 regulates NCOA4-mediated ferritinophagy and protects cancer cells from ferroptosis [0.03%]
α-管蛋白O-乙酰基转移酶1通过调节NCOA4介导的铁死亡相关自噬（ferritinophagy）保护癌细胞免受铁死亡威胁
Francesca Romana Pellegrini,Angela Iuzzolino,Cristina De Palma et al.
Francesca Romana Pellegrini et al.
Background: Microtubules acetylation has emerged as a key regulator of cellular homeostasis, but its roles in autophagy remain understudied. Here, we identify α-tubulin acetyltransferase 1 (ATAT1), the enzyme responsible...
The NAT10/c-Myc positive feedback loop orchestrates tRNA ac4C modification and OTUB1-mediated protein stabilization to drive anaplastic thyroid carcinoma progression [0.03%]
NAT10/c-Myc正反馈环通过tRNA乙基化修饰及OTUB1介导的蛋白稳定驱动甲状腺癌进展
Bo Wei,Haixi Zhao,Shi Chang et al.
Bo Wei et al.
Background: Epitranscriptomic regulation of tRNA modifications has emerged as an important mechanism in cancer progression by influencing oncogenic translation. Anaplastic thyroid carcinoma (ATC) is a highly aggressive ma...
The role of ECM mechanics in cancer mechanotransduction through unraveling the molecular machinery of integrins, FAK, and YAP signaling [0.03%]
整合素、FAK和YAP信号通路的分子机器在揭示癌细胞机械转导中ECM力学作用中的角色
Nourhan Hassan,Burkhard Greve,Martin Götte
Nourhan Hassan
Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signals, is fundamental for maintaining tissue homeostasis and regulating physiological functions. The extracellular matrix (ECM) serves as a critic...
Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling [0.03%]
氯ogenic酸通过抑制HSP60表达和p38信号传导来减轻肾上皮细胞中草酸钙单水化合物晶体诱导的上皮-间充质转化
Paleerath Peerapen,Somsakul Phuangkham,Wanida Boonmark et al.
Paleerath Peerapen et al.
Background: Epithelial-to-mesenchymal transition (EMT) is a prominent process involved in kidney fibrosis. Calcium oxalate monohydrate (COM), a crystalline composition predominantly found in renal stones, is one of the kn...
GPNMB-ECD drives acquired resistance to osimertinib in NSCLC via inducing tumor cell cytoskeletal reorganization [0.03%]
GPNMB-ECD通过诱导肿瘤细胞细胞骨架重塑驱动NSCLC对奥希替尼获得性耐药
Min Zhang,Jia-Qi Wang,Xiao Yang et al.
Min Zhang et al.
Background: Acquired resistance constitutes a major obstacle to the efficacy of osimertinib therapy in nonsmall-cell lung cancer (NSCLC), yet its underlying mechanisms remain incompletely understood. While the soluble ext...