Loss of alpha-kinase 1 contributes to the formation of congenital cataracts in mice [0.03%]
AK1缺乏通过影响γδ晶状上皮细胞的凋亡促进小鼠先天性白内障形成
Hui-Shan Wang,Yu-Xin Yang,Shang-Shang Duan et al.
Hui-Shan Wang et al.
Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging [0.03%]
胆固醇-胆固醇酯代谢异常损害卵巢衰老过程中的卵母细胞质量
Sainan Zhang,Bichun Guo,Junshun Fang et al.
Sainan Zhang et al.
Background: Ovarian aging-induced decline in oocyte quality has been a main issue in women of advanced maternal age. However, the potential mechanism remains elusive, and there are no effective strategies to ameliorate ag...
Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression [0.03%]
具核梭杆菌来源的携带毒力因子DNA的胞外囊泡通过激活AIM2炎性小体促进溃疡性结肠炎发展
Yuqing Zhao,Rui Wu,Yaqian Duan et al.
Yuqing Zhao et al.
Background: Immune disorders and impaired intestinal barrier function resulting from dysbiosis of the intestinal flora play pivotal roles in the pathogenesis of ulcerative colitis (UC). Fusobacterium nucleatum (F. nucleat...
Human umbilical cord mesenchymal stromal cell-derived exosomes alleviate antibiotic-induced intestinal barrier damage by regulating autophagy via the S100G/mTOR signaling pathway [0.03%]
人源脐带间充质干细胞外泌体通过S100G/mTOR信号通路调节自噬来缓解抗生素诱导的肠屏障损伤
Yanji Guo,Yanpeng Li,Meng Shi et al.
Yanji Guo et al.
Background: Antibiotics are a double-edged sword. Long-term, broad-spectrum, and high-dose antibiotic use can lead to the occurrence of related diseases, particularly attracting attention in the context of intestinal barr...
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis [0.03%]
CDK5通过调节巨噬细胞极化和软骨细胞凋亡来调控PPARγ/NF-κB信号通路从而加重肥胖相关性骨关节炎
Yusheng Li,Hengzhen Li,Xin Chen et al.
Yusheng Li et al.
Background: Obesity is an important risk factor for osteoarthritis (OA), but the mechanisms associated with OA progression are still not fully understood. The aim of this study was to investigate the role of cyclin-depend...
E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes [0.03%]
E0703通过靶向ERβ促进GLI3上调，从而缓解辐射引起的淋巴细胞DNA损伤
Zebin Liao,Liangliang Zhang,Zekun Wu et al.
Zebin Liao et al.
Background: Radiotherapy for malignant tumor treatment and irradiation (IR)-related diagnosis damage lymphocytes, which inevitably suppresses immunity and leads to unwanted clinical outcomes. However, a few agents have be...
Cellular osmoregulation enhances porcine embryo development by restoring zygotic genome activation via metabolic-epigenetic crosstalk [0.03%]
基于代谢表观遗传互作的细胞渗透压调节通过恢复卵裂球基因组激活促进猪胚胎发育
Xiangyuan Zhao,Lixiang Liu,Xiaoyu Chu et al.
Xiangyuan Zhao et al.
Introduction: In vitro embryo culture is essential for human assisted reproduction and livestock breeding, yet its efficiency remains limited owing to developmental arrest triggered by suboptimal media composition and env...
Y-chromosome alteration and its impact on cancer progression and metastasis [0.03%]
染色体变异及其对癌症进展和转移的影响
Sarah Ann King,Merana Jahan,Prathiksha Prabhakaraalva et al.
Sarah Ann King et al.
The human Y chromosome (ChrY), which confers male sex determination, contains a relatively small number of protein-coding genes compared to other chromosomes; consequently, its functional impact on adult physiology was once severely unappre...
lncRNA IGFL2-AS1 mediates NSCLC chemoresistance via YBX1-induced HSPA1A/RAP1 activation [0.03%]
长链非编码RNA IGFL2-AS1通过YBX1诱导的HSPA1A/RAP1活化介导非小细胞肺癌的化学耐药性
Hongliang Dong,Yunxiu Xia,Jingjing Qi et al.
Hongliang Dong et al.
Background: The development of drug resistance in cancer is associated with multiple malignant properties, including proliferative progression, metastasis, and stemness. Long noncoding RNAs (lncRNAs) reportedly contribute...
The ISGylation tapestry in cancer: weaving phenotypic plasticity through multidimensional regulatory looms [0.03%]
癌症中的ISGylation图谱：通过多维度调控织机编织表型可塑性
Ruicheng Wu,Fanglin Shao,Siang Boon Koh et al.
Ruicheng Wu et al.
Post-translational modification is an important mechanism for regulating protein function and cell signaling networks. Among these modifications, ISGylation is a ubiquitin-like modification regulated by ISG15. In this review, we explore the...