O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs [0.03%]
O-连接-N-乙酰葡萄糖胺转移酶通过协调转录和可变剪接程序控制精原细胞有丝分裂向减数分裂的过渡及进展
Zhiming Ding,Caiyun Wu,Min Li et al.
Zhiming Ding et al.
Background: O-GlcNAcylation is a post-translational modification (PTM) uniquely catalyzed by O-GlcNAc transferase (OGT), which has been linked to tumorigenesis and neurodegeneration. However, its roles in mammalian sperma...
Lactobacillus acidophilus abolishes oxalate-mediated renal epithelial barrier disruption and calcium oxalate monohydrate crystal adhesion to renal epithelial cells [0.03%]
乳酸菌酸杆菌消除草酸介导的肾上皮屏障破坏和草酸钙一水合物晶体粘附在肾上皮细胞上
Anantaya Putpim,Chadanat Noonin,Paranyu Chawanpaiboon et al.
Anantaya Putpim et al.
Background: It is generally known that kidney stone disease (KSD) is associated with alterations in urinary microbiome, but the roles of the urinary microbiome in KSD pathogenesis remain unclear. ...
Angiogenin alleviates lipotoxicity-induced impairment of skin wound healing [0.03%]
angiogenin缓解脂毒性诱导的皮肤伤口愈合障碍
Min Fu,Yi Wang,Chunyi Wu et al.
Min Fu et al.
Lipotoxicity-induced endothelial dysfunction impairs wound healing in obesity and type 2 diabetes, yet the underlying mechanisms remain elusive. While Angiogenin promotes endothelial function, its role under lipotoxic stress has been unknow...
Yong-Yu Gao,Hai-Yang Li,Si-Yu Yang et al.
Yong-Yu Gao et al.
Swine leukocyte antigen class I (SLA-I) molecules are swine orthologs of human MHC class I molecules and are encoded by three classical loci, SLA-1, SLA-2, and SLA-3. By engaging T-cell receptors (TCRs), these cell-surface proteins present ...
Targeting SLK protects against cerebral ischemia-reperfusion injury by regulating USP8-mediated HIF-1α stabilization and RhoA/ROCK activation [0.03%]
靶向SLK通过调节USP8介导的HIF-1α稳定和RhoA/ROCK活化来抵抗脑缺血再灌注损伤
Yuetao Wen,Zhiyu Xiong,Zhiyuan Wang et al.
Yuetao Wen et al.
Introduction: Acute ischemic stroke (AIS) represents a major global contributor to mortality and chronic disability, with few effective therapeutic targets available. Identifying druggable genes associated with AIS is the...
Correction: Targeting fibroblast activation protein-α to treat renal fibrosis [0.03%]
关于靶向纤维活化蛋白-α治疗肾纤维化的更正通知
Li Gong,Xinyu Lu,Na Ma et al.
Li Gong et al.
Published Erratum
Cellular & molecular biology letters. 2026 Jun 30;31(1):103. DOI:10.1186/s11658-026-00967-z 2026
Hepatocellular carcinoma metastasis-immune microenvironment crosstalk: emerging mechanisms and immunotherapy [0.03%]
肝细胞癌转移-免疫微环境互作：新兴机制及免疫治疗
Wenlong Zhu,Yanjie Zhang,Runze Jiang et al.
Wenlong Zhu et al.
Hepatocellular carcinoma (HCC), the most prevalent type of liver cancer globally, imposes a heavy burden on global public health owing to its consistently high incidence and mortality rates. Owing to the characteristics of its tissue struct...
HIF-1α enhances ferroptosis resistance in anaplastic thyroid carcinoma by suppressing ACSL4-mediated lipid metabolic homeostasis [0.03%]
低氧诱导因子-1α通过抑制ACSL4介导的脂质代谢稳态增强甲状腺癌铁死亡抵抗性
Renjie Xie,Ruixue Geng,Yuchen Wang et al.
Renjie Xie et al.
Background: Anaplastic thyroid carcinoma (ATC) exhibits extreme malignancy with a median survival of less than 6 months. Traditional therapeutic approaches yield limited efficacy, necessitating the urgent identification o...
Sperm surface protein disulfide isomerase ERp57 is crucial for mammalian fertilization but functions independently of IZUMO1 [0.03%]
精子表面蛋白二硫键异构酶ERp57对于哺乳动物受精至关重要，但其功能与IZUMO1无关
Emily Forster,Sophie Dupuis,Côme Ialy-Radio et al.
Emily Forster et al.
Background: Human fertilization requires fusion of spermatozoon and oocyte membranes to form a diploid zygote, beginning with adhesion mediated by spermatozoon IZUMO1 and oocyte JUNO. Current models propose that IZUMO1 di...
Cannabidiol alleviates traumatic brain injury-induced neuronal damage and cognitive deficits by inhibiting ferroptosis via the TRPV1/MCU/PI3K/Akt pathway [0.03%]
大麻二酚通过TRPV1/MCU/PI3K/Akt信号通路抑制铁死亡从而缓解创伤性脑损伤所致的神经元损害和认知障碍
Yejia Xu,Xiong Li,Zhiya Gu et al.
Yejia Xu et al.
Background: Traumatic brain injury (TBI) is a common surgical traumatic condition that poses a significant threat to human health and working capacity. However, effective treatments to improve its prognosis remain limited...