Grx2 deficiency accelerates BMSC senescence and senile osteoporosis via CD36 S-glutathionylation [0.03%]
Grx2通过CD36 S-谷胱甘肽化加速骨髓间充质干细胞衰老和老年性骨质疏松症
Muzhe Li,Taxi Wumiti,Jie Sun et al.
Muzhe Li et al.
Rationale: Senile osteoporosis (SOP) is driven largely by bone marrow mesenchymal stem cell (BMSC) senescence and mitochondrial dysfunction. S-glutathionylation is an important redox modification regulating mitochondrial ...
Bingbing Wu,Chenghong Long,Jiayi Liu et al.
Bingbing Wu et al.
Background: Despite extensive characterization of sperm structures, certain specialized subcellular structures are still not well understood. Among these, the posterior ring has been recognized for over half a century; ye...
TLR4-dependent upregulation of IL-22-producing T cells in the bone niche links to the imbalance of bone homeostasis [0.03%]
骨微环境中的TLR4依赖性促进产生IL-22的T细胞与骨稳态失衡相关
Ji-Eun Kim,Jinyoung Go,Eun-Jin Lee et al.
Ji-Eun Kim et al.
Background: Toll-like receptor 4 (TLR4) activation within the bone marrow (BM) microenvironment regulates proinflammatory cytokines and chemokines, which influence immune activity and bone remodeling. However, the immune ...
Single-cell and spatial transcriptomic analysis reveal distinct tumor microenvironment signatures in primary and recurrent hypopharyngeal squamous cell carcinoma [0.03%]
单细胞和空间转录组分析揭示了原发性和复发性下咽鳞癌肿瘤微环境的特征签名不同
Zhimou Cai,Jinhong Zhang,Yaodong Ding et al.
Zhimou Cai et al.
Background: Hypopharyngeal squamous cell carcinoma (HPSCC) is a rare, highly aggressive malignancy, with recurrence playing a pivotal role in treatment failure and cancer-related mortality. The tumor microenvironment (TME...
Microbiota-mediated modulation of the tumor microenvironment in urological cancers: crosstalk between gut and intratumoral microbiota [0.03%]
泌尿系统肿瘤中肠道菌群和瘤内菌群介导的肿瘤微环境调节：肠道菌群与瘤内菌群相互作用对肿瘤微环境的调解作用
Zhibiao Li,Haoxiang Xu,Lin Yang et al.
Zhibiao Li et al.
Recent studies indicate the gut microbiome as a crucial regulator of cancer therapy, yet its role in urological malignancies remains incompletely understood. High rates of resistance to cornerstone treatments, including immune checkpoint in...
Exercise suppresses IP6K3 to modulate BCAA metabolism and ferroptosis in MASLD [0.03%]
运动通过抑制IP6K3调节支链氨基酸代谢和铁死亡以治疗非酒精性脂肪肝病
Zi-Chen Li,Fang-Fang Xu,Yi Zhao et al.
Zi-Chen Li et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to branched-chain amino acid (BCAA) dysmetabolism and ferroptosis, and exercise is considered protective, yet the underlying mechanism...
TCRζ-driven pre-signaling organization of Lck in Rab11⁺ endosomes shapes TCR activation [0.03%]
TCRζ依赖的Lck在Rab11+内吞体中的预先信号转导组织决定了TCR活化状态
Konstantina Karpouzou,Nikolaos Koutras,Ioannis Tyritidis et al.
Konstantina Karpouzou et al.
Background: T cell activation relies on the precise spatiotemporal regulation of T cell receptor (TCR) signaling at the immunological synapse, where vesicular trafficking coordinates the delivery of key signaling molecule...
O-GlcNAc transferase governs spermatogenic mitotic-to-meiotic transition and progression by coordinating transcription and alternative splicing programs [0.03%]
O-连接-N-乙酰葡萄糖胺转移酶通过协调转录和可变剪接程序控制精原细胞有丝分裂向减数分裂的过渡及进展
Zhiming Ding,Caiyun Wu,Min Li et al.
Zhiming Ding et al.
Background: O-GlcNAcylation is a post-translational modification (PTM) uniquely catalyzed by O-GlcNAc transferase (OGT), which has been linked to tumorigenesis and neurodegeneration. However, its roles in mammalian sperma...
Lactobacillus acidophilus abolishes oxalate-mediated renal epithelial barrier disruption and calcium oxalate monohydrate crystal adhesion to renal epithelial cells [0.03%]
乳酸菌酸杆菌消除草酸介导的肾上皮屏障破坏和草酸钙一水合物晶体粘附在肾上皮细胞上
Anantaya Putpim,Chadanat Noonin,Paranyu Chawanpaiboon et al.
Anantaya Putpim et al.
Background: It is generally known that kidney stone disease (KSD) is associated with alterations in urinary microbiome, but the roles of the urinary microbiome in KSD pathogenesis remain unclear. ...
Angiogenin alleviates lipotoxicity-induced impairment of skin wound healing [0.03%]
angiogenin缓解脂毒性诱导的皮肤伤口愈合障碍
Min Fu,Yi Wang,Chunyi Wu et al.
Min Fu et al.
Lipotoxicity-induced endothelial dysfunction impairs wound healing in obesity and type 2 diabetes, yet the underlying mechanisms remain elusive. While Angiogenin promotes endothelial function, its role under lipotoxic stress has been unknow...