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PRKN mediates the ubiquitination of SCAF8 to reduce the mRNA stability of KLF5 and its transcriptional activation of EFNA3 in colorectal cancer

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Background: Dysregulation in glycolysis within the tumor microenvironment is a hallmark in the context of colorectal cancer (CRC). We aimed to identify critical drivers of glycolysis in CRC and decipher the underlying mechanism. ... ...