Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye [0.03%]
间歇性禁食通过调节CD36及其棕榈酰化来抑制铁死亡从而缓解糖尿病干眼症
Wenhui Wang,Jianwen Xue,Bing Xiao et al.
Wenhui Wang et al.
Combination of Tripterygium glycosides and Lactobacillus paracasei sensitises epithelial ovarian cancer to cisplatin via downregulating Keap1-Nrf2-GPX4 signalling pathway [0.03%]
雷公藤内酯醇联合副干酪乳杆菌通过下调Keap1-Nrf2-GPX4信号通路提高卵巢癌细胞对顺铂敏感性
Meiyun Tian,Xiangdi Zeng,Yanying Zhong et al.
Meiyun Tian et al.
Background: Epithelial ovarian cancer (EOC) is a highly heterogeneous malignancy with significant morbidity and mortality, and cisplatin (DDP) resistance remains a major obstacle in its treatment. Previous studies suggest...
NFAT1+ microglia promote antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1 axis to improve ischemic stroke outcomes [0.03%]
NFAT1+小胶质细胞通过HAS3-HA-LYVE1轴促进抗炎极化和血管生成以改善缺血性卒中预后
Yaochuan Zhang,Xu Cao,Yifu Song et al.
Yaochuan Zhang et al.
Background: Neuroinflammation and angiogenesis are central to post-stroke repair. However, the cellular and molecular mechanisms regulating these events remain incompletely understood. The nuclear factor of activated T ce...
STUB1 downregulates TOP2A through a dual mechanism of ubiquitination and FOXM1-mediated transcription repression, suppressing breast cancer growth and enhancing sensitivity to chemotherapy [0.03%]
STUB1通过泛素化和FOXM1介导的转录抑制双重机制下调TOP2A，抑制乳腺癌生长并增强对化疗的敏感性
Baohui Yue,Qiaoling Xiang,Huimin Qiu et al.
Baohui Yue et al.
Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells [0.03%]
间充质基质细胞体外软骨发生过程中肝素对SMAD2/3的双向调节及抗 hypertrophy 作用
Sven Schmidt,Safak Chasan,Helen F Dietmar et al.
Sven Schmidt et al.
Background: Endochondral instead of chondral differentiation hinders mesenchymal stromal cell (MSC) application for clinical cartilage regeneration. We previously showed that heparin-polyethylene glycol (PEG) hydrogels lo...
Persistent PI3K-AKT signaling fortifies cellular defense against oxidative stress and ferroptosis through augmented mitochondrial fitness [0.03%]
持续的PI3K-AKT信号通过增强线粒体健康来加强细胞对氧化应激和铁死亡的防御
Xin Xie,Shanshan Wang,Wentao Zeng et al.
Xin Xie et al.
Post-translational modifications of selective autophagy receptors: orchestrating cellular homeostasis, disease pathogenesis, and therapeutic opportunities [0.03%]
选择性自噬受体的翻译后修饰：协调细胞稳态、疾病发生及治疗机会
Wenyun Zhu,Xiaohui Wang,Qing Li et al.
Wenyun Zhu et al.
Endothelial Ffar4 protects against diabetic kidney disease by potentiating endogenous retinoic acid metabolism [0.03%]
内皮FFAR4通过增强内源性视黄酸代谢来保护糖尿病肾脏疾病
Jiayu Li,Siyuan Cui,Wei Wang et al.
Jiayu Li et al.
G-quadruplex stabilization via small molecules as a potential anti-cancer strategy [0.03%]
通过小分子稳定G-四链体作为潜在的抗肿瘤策略
Chunshuang Li,Jialian Liu,Ruoxi Wang
Chunshuang Li
mTORC1 as a metabolic rheostat coordinates hormonal signals and cellular proliferation to sustain endometrial competence [0.03%]
mTORC1作为代谢节流阀协调激素信号和细胞增殖以维持子宫内膜能力
Yadong Sun,Shuo Wan,Mingyue Zhao et al.
Yadong Sun et al.