SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer [0.03%]
SLC25A11介导的线粒体氧化还原状态和脂质过氧化重构通过NRF2依赖性铁死亡抵抗促进胆道癌发生发展
Yu-Yu Lin,Han-Hsi Kuo,Zhao-Jing He et al.
Yu-Yu Lin et al.
The neuro-immune insights of itch: peripheral mechanisms and central glial contributions [0.03%]
痒感的神经-免疫机制研究：外周和中枢胶质细胞的作用
Zhe Li,Ning Yu,Sidi Feng et al.
Zhe Li et al.
Targeting integrin αVβ3-Ptgs2-mTOR signaling rescues bone formation in osteoporosis: from molecular mechanism toward therapy [0.03%]
靶向整合素αVβ3-Ptgs2-mTOR信号通路可治疗骨质疏松症：从分子机制到治疗方法
Changshun Chen,Jinyi Gu,Chenhui Yang et al.
Changshun Chen et al.
Eugenia A Tiukacheva,Yegor Vassetzky,Sergey V Razin et al.
Eugenia A Tiukacheva et al.
Nuclear receptor-binding SET domain (NSD) proteins have been initially described as methyltransferases specific to lysine-36 in histone H3 and associated with active chromatin. However, their role in the regulation of transcription and in o...
Ze-Sen Feng,Jie Luo,Xiao-Cui Chen et al.
Ze-Sen Feng et al.
G-quadruplex structures are key regulators of mammalian spermatogenesis [0.03%]
G-四链结构调控哺乳动物精子发生的关键因素
Shuo Li,Yixiao Ma,Haoxin Shi et al.
Shuo Li et al.
MPP7 inhibits tumor metastasis through promoting snail degradation in clear cell renal cell carcinoma [0.03%]
MPP7通过促进透明细胞肾细胞癌中snail蛋白降解抑制肿瘤转移
Mi Zhang,Juan Zhang,Yan Zhou et al.
Mi Zhang et al.
Background: Tumor metastasis is a major factor of high recurrence and mortality in clear cell renal cell carcinoma (ccRCC), but its underlying mechanism remains elusive. This study focuses on investigating the impact and ...
MFSD2A: a molecular nexus linking blood-brain barrier, lipid metabolism, and ischemia-reperfusion injury [0.03%]
血脑屏障、脂质代谢及缺血再灌注损伤之间的分子纽带——MFSD2A基因
Chunyan Li,Muhammad Mustapha Ibrahim,Cheng Fang
Chunyan Li
Major facilitator superfamily domain-containing protein 2A (MFSD2A) is a central molecular player in maintaining the blood-brain barrier (BBB). It exerts dual protective effects in ischemia-reperfusion injury (IRI): MFSD2A regulates the lip...
GPR43 deficiency aggravates sepsis by promoting gut microbiota-dependent barrier disruption and HIF-1α-ENO1 axis-mediated M1 polarization of macrophages [0.03%]
GPR43缺乏通过促进肠道微生物群依赖性屏障破坏和HIF-1α-ENO1轴介导的巨噬细胞M1极化而加重脓毒症
Mingyang Tang,Hongru Li,Fei Tang et al.
Mingyang Tang et al.
Impact of sperm fractionation on chromosome positioning, chromatin integrity, DNA methylation, and hydroxymethylation level [0.03%]
精子分选对染色体定位、染色质完整性、dna甲基化和羟甲基化水平的影响分析
Zuzanna Graczyk,Jagoda Kostyk,Julia Pospieszna et al.
Zuzanna Graczyk et al.
Background: Sperm chromosomes are nonrandomly organized in the cell nucleus, which plays an important role in the regulation of early embryo development, which is determined by the specific localization of sperm chromosom...