Rv1983 promotes mycobacterial dissemination by triggering ferroptosis through GPX4 ubiquitination [0.03%]
Zilu Qu,Yuanyuan Zhou,Qinzhen Cai et al.
Zilu Qu et al.
Background: Ferroptosis, a unique form of regulated cell death induced by iron-dependent lipid peroxidation, has been implicated in the pathogenesis of Mycobacterium tuberculosis (Mtb). However, the role of Mtb proteins, ...
RING finger E3 ubiquitin ligases: novel therapeutic opportunities in melanoma [0.03%]
新型泛素连接酶(RING指结构域E3泛素蛋白连接酶)在黑色素瘤治疗中的作用与机会
Ji-Fang Zhang,Long-Tian Li,Yue-Ying Yang et al.
Ji-Fang Zhang et al.
Melanoma is an aggressive type of cancer that is prone to developing resistance to targeted therapies and immunotherapies, so it is necessary to seek novel therapeutic opportunities. RING finger E3 ubiquitin ligases (RNFs) play a crucial ro...
Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion [0.03%]
内质网和高尔基体应激信号介导的蛋白质分泌调控
Ketsia Bakambamba,Manon Nivet,Sophie Martin et al.
Ketsia Bakambamba et al.
The eukaryotic secretory pathway (SP) is essential to ensure cellular functions and multicellular communication. The early SP is constituted mostly of the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Go...
Regulation of mitochondrial function during spermatogenesis and sperm maturation [0.03%]
调节生精过程中和精子成熟过程中的线粒体功能
Kai Meng,Ziming Zhu,Haocheng Jia et al.
Kai Meng et al.
With the recent increase in the incidence of male infertility, greater attention is being paid to male reproductive health. The causes of male infertility are complex, and damage occurring during any process from spermatogenesis to fertiliz...
CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion [0.03%]
新型的体外组织模型中的CRISPR和化合物筛选鉴定出DNA损伤反应1和血管紧张素转换酶作为癌症细胞入侵的调节因子
Junnan Liu,Wencheng Jiang,Xue Wang et al.
Junnan Liu et al.
Background: Bladder cancer (BC) can be characterized clinically as either non-muscle-invasive (NMIBC) or muscle-invasive (MIBC). While NMIBC generally has a favorable prognosis, MIBC is characterized by high morbidity and...
DNASE1L3 functions as a significant metastatic suppressor by attenuating MYH9/β-catenin/c-Jun/LncRNA-KDM4A-induced E-cadherin ubiquitination degradation in nasopharyngeal carcinoma [0.03%]
DNA酶1L3通过减弱MYH9/β-catenin/c-Jun/LncRNA-KDM4A诱导的E-钙粘蛋白泛素化降解在鼻咽癌中发挥显著的转移抑制作用
Xingyu Tao,Xiong Liu,Xiangdong Zhao et al.
Xingyu Tao et al.
Background: Deoxyribonuclease 1 Like 3 (DNASE1L3) is a member of the deoxyribonuclease I family that is associated with some diseases, including systemic lupus erythematosus and hypocomplementemic urticarial vasculitis. R...
Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes [0.03%]
血清素作用生理和病理过程中的作用：神经传递之外
Jia-Ming Wang,Feng-Hao Zhang,Yi-Ru Chen et al.
Jia-Ming Wang et al.
Serotonin, also known as 5-HT, is a classical neurotransmitter produced both in the nervous system and in non-nervous system. Its involvement in various fundamental physiological processes and pathogenic conditions is significant, as it bin...
BRD2 upregulation as a pan-cancer adaptive resistance mechanism to BET inhibition [0.03%]
BRD2上调作为对BET抑制产生适应性抵抗的泛癌机制
Suyakarn Archasappawat,Juliette Jacques,EunJung Lee et al.
Suyakarn Archasappawat et al.
Bromodomain and extraterminal motif (BET) inhibitors, such as JQ1, are promising cancer therapeutics that target epigenetic regulators, particularly BRD4. However, resistance to BET inhibitors (BETi) limits their clinical utility, necessita...
IRE1-XBP1driven induction of TMED9 stabilizes ATF6 during ER stress to promote cell survival [0.03%]
由IRE1-XBP1在内质网应激时诱导TMED9稳定ATF6以促进细胞存活
Chen Lenchisky,Areen Muhammad Majadly,Irena Bronshtein Berger et al.
Chen Lenchisky et al.
Background: The endoplasmic reticulum (ER) plays a central role in protein homeostasis by facilitating the folding, modification, and quality control of secretory and membrane proteins. Disruption of ER function results i...
Differentiation state affects PD-L1 expression in cutaneous melanoma: a systematic review [0.03%]
分化状态影响皮肤黑色素瘤中PD-L1的表达：系统性综述
Teitur Sævarsson,Hong Nhung Vu,Eiríkur Steingrímsson et al.
Teitur Sævarsson et al.
Background: Programmed death ligand-1 (PD-L1) is a widely used biomarker for immunotherapy in melanoma. The expression of PD-L1 in melanoma cells is known to vary considerably among and within patients' tumor samples. Rec...