Reticulon Protein-1C: A New Hope in the Treatment of Different Neuronal Diseases [0.03%]
视神经疾病治疗新希望—网状蛋白1C研究进展
Federica Di Sano,Mauro Piacentini
Federica Di Sano
Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calc...
Marcus Fernandes de Oliveira,Nívea Dias Amoêdo,Franklin David Rumjanek
Marcus Fernandes de Oliveira
Cancer cells display abnormal morphology, chromosomes, and metabolism. This review will focus on the metabolism of tumor cells integrating the available data by way of a functional approach. The first part contains a comprehensive introduct...
Edgar D Yoboue,Anne Devin
Edgar D Yoboue
Mitochondrial biogenesis is a complex process. It necessitates the contribution of both the nuclear and the mitochondrial genomes and therefore crosstalk between the nucleus and mitochondria. It is now well established that cellular mitocho...
Treatment with Y-27632, a ROCK Inhibitor, Increases the Proinvasive Nature of SW620 Cells on 3D Collagen Type 1 Matrix [0.03%]
ROCK抑制剂Y-27632的处理可增强SW620细胞在I型胶原三维基质中的侵袭能力
Ramana Vishnubhotla,Shruthi Bharadwaj,Shan Sun et al.
Ramana Vishnubhotla et al.
The concept of using tissue density as a mechanism to diagnose a tumor has been around for centuries. However, this concept has not been sufficiently explored in a laboratory setting. Therefore, in this paper, we observed the effects of cel...
Keith M Jacobs,Sandeep R Bhave,Daniel J Ferraro et al.
Keith M Jacobs et al.
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range...
Altered gene expression, mitochondrial damage and oxidative stress: converging routes in motor neuron degeneration [0.03%]
基因表达改变、线粒体损伤和氧化应激：运动神经元变性共同作用的途径
Luisa Rossi,Cristiana Valle,Maria Teresa Carrì
Luisa Rossi
Motor neuron diseases (MNDs) are a rather heterogeneous group of diseases, with either sporadic or genetic origin or both, all characterized by the progressive degeneration of motor neurons. At the cellular level, MNDs share features such a...
Enrico Desideri,L Miguel Martins
Enrico Desideri
Mitochondria are cellular energy generators whose activity requires a continuous supply of oxygen. Recent genetic analysis has suggested that defects in mitochondrial quality control may be key factors in the development of Parkinson's dise...
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells [0.03%]
线粒体NADPH依赖异柠檬酸脱氢酶在癌细胞中的作用
Katarína Smolková,Petr Ježek
Katarína Smolková
Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self...
Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison [0.03%]
氧化应激、肿瘤微环境及代谢重编程：魔鬼组合
Tania Fiaschi,Paola Chiarugi
Tania Fiaschi
Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with st...
Early decrease in respiration and uncoupling event independent of cytochrome C release in PC12 cells undergoing apoptosis [0.03%]
PC12细胞凋亡早期呼吸下降和与细胞色素C释放无关的解偶联事件
Libera Berghella,Elisabetta Ferraro
Libera Berghella
Cytochrome c is a key molecule in mitochondria-mediated apoptosis. It also plays a pivotal role in cell respiration. The switch between these two functions occurs at the moment of its release from mitochondria. This process is therefore ext...