The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
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Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reac... ...
