Key divisions and cell specification during embryo pattern formation require SMU1-mediated splicing of CAK genes in Arabidopsis [0.03%]
SMU1介导的CAK基因剪接在拟南芥胚胎图案形成中的关键分化和细胞特化过程中起作用
Xiaoyi Huang,Yue Liu,Yajun Cai et al.
Xiaoyi Huang et al.
Embryonic pattern formation and cell specification require precise cell division and cell cycle regulation. Splicing factors and the splicing of precursor mRNA (pre-mRNA) play significant roles in embryo development. However, how splicing f...
Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus [0.03%]
HBV相关肝细胞癌的全基因组关联研究鉴定出FAM114A1位点的功能变异
Hong-Ping Yu,Bang-De Xiang,Ji Qian et al.
Hong-Ping Yu et al.
Liver cancer ranks sixth in cancer incidence and third in cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the primary histological subtype, and hepatitis B virus (HBV) carriers have a higher risk of HCC. Although several ...
Epigenetic regulation of cilia stability and kidney development by the chromatin remodeling SWI/SNF complex in zebrafish [0.03%]
斑马鱼SWI/SNF染色质重塑复合体对纤毛稳定性和肾脏发育表观遗传调控的作用机制研究
Xiaoyu Cheng,Qianshu Zhu,Shilin Ma et al.
Xiaoyu Cheng et al.
Cilia are vital subcellular organelles whose assembly is regulated by master transcription factors, such as Foxj1 and Rfx. However, the mechanisms of epigenetic regulation over cilia stability remain largely unclear. Here, we investigate th...
Transcriptomic landscape of Marchantia polymorpha sexual organs at single-nucleus resolution [0.03%]
拟卵叶柄苔有性器官的单核转录组谱系图
Yuying Zeng,Yuqing Cai,Zhencheng Tu et al.
Yuying Zeng et al.
Marchantia polymorpha, a model liverwort, provides a valuable system for investigating the evolution of plant sexual reproduction. To explore the cellular landscape of its reproductive structures, we generate a single-nucleus transcriptomic...
Xiaqing Wang,Tianyi Wang,Ruyang Zhang et al.
Xiaqing Wang et al.
Stalk lodging is a major problem in maize production, usually causing significant yield losses due to weak stalk strength. Understanding the genetic basis of stalk strength is crucial for improving maize lodging resistance. In this study, w...
Dual-target CRISPR-Cas12 diagnostics based on asymmetrically chemical-modified DNA probe [0.03%]
基于不对称化学修饰DNA探针的双靶CRISPR-Cas12诊断技术
Xinge Wang,Yangcan Chen,Yanping Hu et al.
Xinge Wang et al.
CRISPR-based nucleic acid detection technologies have revolutionized infectious disease detection and environmental monitoring by leveraging RNA-DNA complementarity to enable rapid, precise, and cost-effective detection of targets. However,...
E75-induced Toll/NF-κB signaling cooperates with Notch and Hippo pathways to promote tumor malignancy [0.03%]
E75诱导的Toll/NF-κB信号与Notch和Hippo途径协作以促进肿瘤恶性进展
Xianping Wang,Yifan Guo,Chenglong Wang et al.
Xianping Wang et al.
Genetic and molecular mechanisms of phytohormone-mediated seed size control in crops [0.03%]
农作物中植物激素介导的种子大小控制的遗传和分子机制
Shan Jiang,Lian Wu,Luojiang Huang et al.
Shan Jiang et al.
Seed size is an important agronomic trait determining crop yield. Identifying key genes involved in seed size regulation and elucidating their molecular mechanisms are of great significance for crop breeding. Recent studies in crops have un...
A universal cost-efficient sample labeling approach for multiplexed single cell RNA-seq based on recombinant HUH-endonuclease-agglutinin tagging [0.03%]
一种基于重组HUH端内切酶-凝集素标记的多重单细胞RNA测序通用且经济高效的样本标签方法
Quanyong Zhang,Maorong Li,Luemou Shen et al.
Quanyong Zhang et al.
Recent advances in single-cell transcriptomics have revolutionized our understanding of cellular diversity and tissue heterogeneity, providing unprecedented insights into biological and medical research. However, the high per-assay cost lim...
To see and to know: the power of live imaging in illuminating and decoding biological complexity [0.03%]
看与知：活细胞成像技术揭示和解读生物复杂性
Miaoling Yang,Zhuo Du
Miaoling Yang
Live imaging enables direct observation of dynamic biological processes, capturing their progression from molecular to organismal scales in space and time. Through high-resolution observation, it provides a powerful means to decode biologic...