LRRC71 stabilizes SEPT4 protein to ensure sperm annulus integrity and male fertility [0.03%]
LRRC71通过稳定SEPT4蛋白来维持精子环胞骨架的完整性和雄性生育力
Jinmei Cheng,Yu Wang,Yueming Wang et al.
Jinmei Cheng et al.
The structural integrity of the sperm flagellum is essential for male fertility, and its impairment is associated with reduced sperm motility. The sperm annulus is a septin-based fibrous ring that demarcates the midpiece and the principal p...
Incomplete penetrance in neurogenetic disorders: current insights and emerging perspectives [0.03%]
神经遗传病不全外显性的现状及新视角
Jiao-Jiao Xu,Dian-Fu Chen,Zhi-Ying Wu
Jiao-Jiao Xu
Neurogenetic disorders have been recognized clinically for decades, and advances in clinical and genetic studies have identified more than 1700 monogenic causes of neurological diseases. Various types of mutations, including missense, trunc...
Large-scale low-coverage whole-genome sequencing reveals the genetic architecture of wool and growth traits in fine-wool sheep [0.03%]
大规模低覆盖度全基因组测序揭示了细毛羊纤维和生长性状的遗传结构
Jianxin Shi,Changchun Lin,Peiling Wei et al.
Jianxin Shi et al.
Breeding sheep with superior growth performance and wool quality is essential for the sustainability of the fine-wool sheep industry. In this study, we perform low-coverage whole-genome sequencing (lcWGS) on 3842 individuals from 5 sheep br...
Beyond radiogenomics: advancing imaging integration and multi-omics horizons in cancer precision medicine [0.03%]
超越放射基因组学：在癌症精准医学中推进影像整合和多组学视角
Yuming Chen,Huiqin Li,Silu Chen et al.
Yuming Chen et al.
Cancer remains the leading cause of death worldwide, presenting substantial challenges to precision medicine due to its complex heterogeneity. Radiogenomics, as a method combining quantitative radiologic data with genomic information, provi...
Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder [0.03%]
非小细胞肺癌对KRASG12C抑制剂产生抗性的进化路径研究
Jiahui Xu,Shijia Wang,Ziming Wang et al.
Jiahui Xu et al.
The ZmGF14-6-ZmCDC48 module controls endosperm cell proliferation and kernel weight in maize [0.03%]
ZmGF14-6-ZmCDC48模块控制玉米胚乳细胞增殖和籽粒重
Long Zhang,Yongbin Dong,Ju Wu et al.
Long Zhang et al.
Tapt1 deficiency in mice impairs pulmonary lipid homeostasis and normal postnatal respiration by targeting ABCA3 for autophagy-lysosomal degradation [0.03%]
靶向自噬溶酶体降解ABCA3导致胎鼠肺脂质代谢紊乱及呼吸障碍
Dandan Tan,Lu Cai,Li Yuan
Dandan Tan
TAPT1, which encodes a highly conserved multi-pass transmembrane protein termed transmembrane anterior posterior transformation 1 (TAPT1), has been reported as a disease-causing gene, but its physiological role in mice remains to be elucida...
Gapless comparative genomics reveals effector landscape and adaptive selection signatures in Plasmodiophora brassicae [0.03%]
无间隙比较基因组学揭示了寄生在油菜上的丝核菌效应子景观和适应性选择信号
Jianbiao Wang,Shuxin Xuan,Xizhe Sun et al.
Jianbiao Wang et al.
Yorkie/Scalloped-OVOL-Rac1 axis controls insect wing development by promoting cell proliferation [0.03%]
Yorkie/O伏尔- Rac1轴通过促进细胞增殖控制昆虫翅发育
Jing Zhang,Yanan Zhang,Babar Hussain Chang et al.
Jing Zhang et al.
The regulation of organ size is a fundamental question in developmental biology, and insect wings provide a powerful model for elucidating the genetic mechanisms underlying morphogenesis. Although the conserved Hippo signaling pathway plays...
Construction of a high-quality indexed EMS mutant library and a pipeline for identifying causal mutations in wheat by whole-exome sequencing [0.03%]
基于全外显子组测序的EMS诱变体库构建及等位基因系列解析鉴定平台建立
Dong Cao,Guangrui Liu,Yunlong Liang et al.
Dong Cao et al.