Transcriptional, epigenetic, and post-translational regulation of plant autophagy [0.03%]
植物自噬的转录、表观遗传和翻译后调节
Yao Wang,Chao-Ying Liu,Liang Chen et al.
Yao Wang et al.
Autophagy is a highly conserved intracellular recycling process in eukaryotes that delivers cellular components to the lysosome or vacuole for degradation, thereby maintaining intracellular homeostasis. Acting as a quality control system, a...
Lipid metabolism and metabolites: emerging roles in systemic physiology and metabolic diseases [0.03%]
脂质代谢与脂质代谢产物：在系统生理学和代谢性疾病中作用初探
Jiesi Xu,Dongliang Lu,Xun Huang
Jiesi Xu
Lipids function as central regulators of cellular and systemic physiology through their roles in energy storage, membrane architecture, signaling, and nutrient transport. Maintaining lipid metabolic balance is essential, as its disruption u...
ATP6V1C1 deficiency impairs auditory and vestibular hair cell function and leads to sensorineural hearing loss in humans and mice [0.03%]
ATP6V1C1缺陷损害听觉和前庭毛细胞功能并导致人类和小鼠感觉神经性听力损失
Qingyue Yuan,Hao Zheng,Jun Xu et al.
Qingyue Yuan et al.
Multiple genes encoding v-ATPase subunits are associated with various forms of syndromic hearing loss. Their functions in hair cells, the key sensory cells required for hearing and balance, remain unclear. In this study, linkage analysis an...
Whole-genome sequencing reveals Yunnan as the crossroads of East and Southeast Asia for human gene flow [0.03%]
全基因组测序揭示云南是东亚和东南亚人类基因流动的交汇点
Xiaobo Qian,Bo Li,Jianmei Liu et al.
Xiaobo Qian et al.
Yunnan Province has long served as a key nexus facilitating economic and cultural exchanges between East Asia, Southeast Asia, and Qinghai-Tibet Plateau. However, previous genetic studies were largely limited by sparse marker density, low s...
Multidisciplinary exploration of ancient atherosclerosis: paleo-genomic and paleo-nutritional analysis of a 13th century artificial mummy in China [0.03%]
中国13世纪木乃伊的古基因组与古营养学分析及古代动脉粥样硬化的多学科探索
Bangyan Wang,Rui Wang,Duo Zheng et al.
Bangyan Wang et al.
The 13th-century Changzhou Mummy, from the Lower Yangtze region in China, is the earliest known East Asian case of an artificially mummified body employing mercury and cinnabar enema without evisceration. This study conducts multidisciplina...
SYMPK interacts with KIF20A and NUMA1 to coordinate spindle organization and safeguard oocyte meiotic maturation [0.03%]
SYMPK通过与KIF20A和NUMA1相互作用来协调纺锤体组织并保障卵母细胞的成熟发育
Bei Chen,Mofan Zhou,Jiaqi Wang et al.
Bei Chen et al.
Mammalian oocyte maturation relies on the precise assembly of the acentrosomal spindle, and its disruption causes aneuploidy and developmental failure. Symplekin (SYMPK), a 3'-end processing scaffold with emerging functions in regulating ch...
Polyploidy-induced epigenetic priming underlies enhanced salinity tolerance in soybean [0.03%]
多倍体现在诱导表观遗传印记从而提高大豆耐盐性
Lei Wang,Yun Li,Ying Liu et al.
Lei Wang et al.
K48- and K63-linked ubiquitination in plant development and stress responses [0.03%]
植物发育和应答逆境中的K48和K63连接的泛素化
Yueni Fan,Wenguan Zhou,Baoshan Xian et al.
Yueni Fan et al.
Ubiquitination is a crucial post-translational modification regulating numerous biological processes in plant development and stress responses. This process involves the covalent attachment of ubiquitin molecules to different target protein...
High-quality genome assembly of Carex capillifolia reveals genetic adaptations to drought stress in the Qinghai-Xizang Plateau [0.03%]
西藏毛苔草高质量基因组组装揭示青藏高原干旱适应性遗传机制
Yanli Xiong,Qingqing Yu,Yi Xiong et al.
Yanli Xiong et al.
Carex capillifolia is an ecologically and economically important fodder grass widely distributed across the Northern Hemisphere, particularly in the Qinghai-Xizang Plateau. Research into its genetic diversity and genomic architecture has be...
Tiny genome with big impact: mitochondrial DNA in cardiovascular health [0.03%]
微小却影响巨大：心血管健康领域的线粒体DNA
Yafang Yang,Jiaoyu Li,Lu Qian et al.
Yafang Yang et al.
Cardiovascular diseases remain the leading cause of mortality worldwide. Mitochondrion, a key cellular organelle, harbors its own mitochondrial DNA (mtDNA) fundamental to cellular energy production through oxidative phosphorylation (OXPHOS)...