Novel variants of TP63 identified in Chinese families with split-hand/foot malformation [0.03%]
TP63的新变异在中国分裂手足畸形家系中的发现
Xuyu Gu,Siyuan Tao,Xiaodong Wang et al.
Xuyu Gu et al.
Objective: Split-hand/foot malformation (SHFM) is a group of congenital birth defects affecting the hands and feet, significantly impairing patients quality of life. The TP63 gene encodes the p63 protein, heterozygous TP6...
Editorial: Omic technologies, integrative methods and translational approaches in brain health and disease [0.03%]
述评：脑健康与疾病中的 omic 技术、集成方法和转化方法
Paolo Abondio,Francesco Bruno,Shaoyu Wang
Paolo Abondio
Integrated multi-omics analysis identifies candidate eRNA-associated signatures shared between osteoarthritis and type 2 diabetes [0.03%]
整合多组学分析鉴定出骨关节炎和2型糖尿病共有的候选增强型转录本相关标志物
Danni Huang,Junying Wu,Jinhua Chen et al.
Danni Huang et al.
Background: Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) frequently coexist and share inflammatory and metabolic disturbances, but the immune-epigenetic features that may overlap between these conditions remain...
Genomic approaches to understanding pregnancy phenotypes and birth outcomes and their links with long-term maternal and offspring health-the value of distinguishing maternal and fetal genetic effects [0.03%]
基因组方法在理解妊娠表型和出生结局及其与长期母体和子代健康联系中的价值：区分母体和胎儿遗传效应的重要性
Ge Zhang,Rachel M Freathy,Bo Jacobsson et al.
Ge Zhang et al.
Pregnancy is a biologically complex period with profound implications for maternal and offspring health. Adverse pregnancy outcomes such as pre-eclampsia, gestational diabetes, preterm birth, and growth restriction contribute substantially ...
Bidirectional association between zinc and liver cirrhosis: evidence from mendelian randomization and clinical validation [0.03%]
锌与肝硬化双向关联的孟德尔随机化和临床验证证据
Liu-Dan Liang,Ying Yang,Qi-Wen Huang et al.
Liu-Dan Liang et al.
Background: It remains unclear whether low blood zinc levels in cirrhosis patients are a cause or a consequence of the disease. Methods: ...
Correction: Distribution of CYP2C19 genetic polymorphisms and pharmacogenomic implications in 11,710 patients with cardiovascular and cerebrovascular conditions: a large population-based study in eastern China [0.03%]
对中国东部11710名心血管和脑血管疾病患者的CYP2C19基因多态性分布及药物基因组学意义的大规模人群研究的更正通知
Minfei Peng,Minmin He,Ying Chen et al.
Minfei Peng et al.
[This corrects the article DOI: 10.3389/fgene.2026.1830873.]. Keywords: CYP2C19; clopidogrel; genetic epidem...
Published Erratum
Frontiers in genetics. 2026 Jul 15:17:1925477. DOI:10.3389/fgene.2026.1925477 2026
Rethinking polyphenol oxidases in wheat: beyond the "low-PPO is always better" paradigm [0.03%]
小麦多酚氧化酶的再思考：“低PPO总是更好”的观念亟需改变
Anna Paola Minervini,Silvia Procino,Anna Maria Pellegrini et al.
Anna Paola Minervini et al.
Polyphenol oxidase (PPO) activity is a key determinant of wheat quality, influencing enzymatic browning of end products while also contributing to biochemical defence against (a)biotic stresses. In this review, we present a comprehensive st...
Understanding normal cardiac morphogenesis and its disruptions: a journey through pathways [0.03%]
理解正常心脏形态发生及其破坏：一条途径的旅程
Aline L Saliba,Jorge Afiune,Aline Pic-Taylor et al.
Aline L Saliba et al.
Congenital heart diseases (CHDs) encompass a broad spectrum of structural anomalies with substantial clinical and genetic heterogeneity. They are the most common birth defects in humans, and a leading cause of paediatric morbidity and morta...
Assessment of paralogue annotation for improving diagnostic accuracy in CALM1, CALM2, and CALM3 genes [0.03%]
评估旁系同源物注释以提高CALM1、CALM2和CALM3基因诊断准确性的评价
Kathryn M Curry,Amar Mujkic,Natalie Syverud et al.
Kathryn M Curry et al.
The calcium (Ca2+) sensor calmodulin (CaM) genes CALM1, CALM2, and CALM3 were recently included in the American College Medical Genetics and Genomics (ACMG) secondary findings (SF) list, given their significance in causing long QT syndrome ...
Genotype-based severity scoring system in Wolfram Syndrome: correlation with onset of cardinal symptoms and WFS1 gene variant types [0.03%]
wolfram综合征的基因型严重度评分系统及其与主要症状发病年龄和WFS1基因突变类型的关联性研究
Liam Oiknine,Abby F Tang,Evan M Lee et al.
Liam Oiknine et al.
Background: Wolfram syndrome is a rare genetic disorder characterized by antibody-negative early-onset atypical diabetes mellitus, optic nerve atrophy, sensorineural hearing loss, central diabetes insipidus (arginine vaso...