Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine [0.03%]
厄瓜多尔遗传镶嵌图谱——梅斯蒂索人、印第安人和非裔厄瓜多瑞人在生物学和适应性上的差异。对公共卫生活动及精准医疗的启示意义
Fabricio González-Andrade
Fabricio González-Andrade
Introduction: Understanding human biological diversity is fundamental to improving health and addressing inequities, yet most genomic and biomedical studies remain focused on European and Asian populations. Latin American...
Application of trio-based whole-exome sequencing in fetal ultrasound anomalies: a single-center retrospective study of 454 cases [0.03%]
三联体外显子组测序在胎儿超声结构异常中的应用研究——单中心454例行回顾性分析
Dongyi Yu,Dairong Feng,Jiangbo Qu et al.
Dongyi Yu et al.
This study assessed the diagnostic effectiveness of trio-WES compared to CMA in fetuses with ultrasound anomalies and explored optimal prenatal testing strategies. A retrospective review included 454 fetuses who underwent trio-WES and/or CM...
Editorial: Responses and adaptation of plants to abiotic stress: genetics, evolution and molecular insights [0.03%]
植物应对非生物胁迫的响应与适应：遗传、进化及分子见解
Yang Tao,Xilan Yang,Zhiqiang Wang
Yang Tao
Mechanistic study of TFE3 breakage in TFE3-rearranged renal cell carcinoma: the perspective of non-canonical DNA structures and their stability [0.03%]
TFE3断裂在TFE3重排肾细胞癌中的作用机制研究：非经典DNA结构及其稳定性的视角
Xiaopo Zhang,Qinshuang Dang,Xinghe Pan et al.
Xiaopo Zhang et al.
Background/objectives: To address the unelucidated mechanisms of breakpoint formation in TFE3-rearranged renal cell carcinoma (TFE3-rRCC), this study characterizes breakpoint distribution within the TFE3 gene. We further ...
Revealing the key modules and potential prognostic markers of gastric cancer transformation based on weighted gene co-expression networks [0.03%]
基于加权基因共表达网络的胃癌转化关键模块和潜在预后标志物的研究
Heng Li,Wen Li,Zhen Yang et al.
Heng Li et al.
Background: This study aims to identify key modules and targets during the transition from gastric precancerous lesions to gastric cancer by performing weighted gene co-expression network analysis (WGCNA) on gene microarr...
Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations [0.03%]
circular RNA在急性胰腺炎中的交叉作用：从分子机制到诊断和治疗创新桥梁
Jing Chen,XiaoLing Chen,Fei He
Jing Chen
Acute pancreatitis (AP) is a severe inflammatory condition that frequently leads to systemic inflammatory response syndrome and multiple organ failure. Despite the increasing occurrence, targeted therapies remain unavailable. CircRNAs have ...
Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia [0.03%]
组约来稿：拨开迷雾见真相——揭开大脑衰老和神经退行性疾病的面纱
Victoria Campos-Peña
Victoria Campos-Peña
Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential [0.03%]
心力衰竭中非编码RNA的表观遗传调控机制及其治疗潜力（纠正后）
Yubo Ren,Bomeng Zhao,Luo Lv et al.
Yubo Ren et al.
[This corrects the article DOI: 10.3389/fgene.2025.1677797.]. Keywords: circular RNA; epigenomics; heart fai...
Published Erratum
Frontiers in genetics. 2025 Nov 24:16:1746339. DOI:10.3389/fgene.2025.1746339 2025
A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas [0.03%]
基于网络的复发IDH野生型胶质瘤预后标志物发现
Yang Liu,Jason Huse,Kasthuri Kannan
Yang Liu
Background: Isocitrate dehydrogenase wild-type (IDH wild-type) gliomas represents the most aggressive subtype of diffuse gliomas, characterized by therapeutic resistance and dismal prognosis. Despite advances in molecular...
Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models [0.03%]
三代人中的良性镶嵌染色体结构变异：来自临床和计算模型的发育修正机制证据
Jiayu Ruan,Qinhao Song,Yue Hu et al.
Jiayu Ruan et al.
Objective: This study investigates the intergenerational transmission of benign mosaic supernumerary marker chromosomes or structural variant chromosomes (SMCs/SVs) and explores the developmental mechanisms that maintain ...