APOE ε4-associated hippocampal atrophy trajectories across the Alzheimer's disease continuum: a systematic review, meta-analysis, and longitudinal validation [0.03%]
阿爾茨海默病連續譜中與APOEε4相關的海馬體萎縮軌跡：系統性綜述、元分析及縱向驗證
Minnuo Cai,Hang Lei,Yuetong Zhang et al.
Minnuo Cai et al.
Background: Predicting patient-specific neurodegenerative trajectories is essential for targeted interventions in Alzheimer's disease. Although the APOE-ε4 allele is the predominant genetic risk factor for hippocampal at...
Imaging biomarkers in neurodegenerative diseases: advances and challenges [0.03%]
神经退行性疾病影像生物标志物的研究进展与挑战
Shreyasi Majumdar,Puneet K Samaiya,Sahabuddin Ahmed et al.
Shreyasi Majumdar et al.
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), represent a major global health burden. Imaging biomarkers have emerged...
Beyond single-modality screening: toward an EEG-IoT dual-stream framework for early detection of mild cognitive impairment in community-dwelling older adults [0.03%]
超越单一模式筛查：面向社区老年人轻度认知障碍早期检测的EEG-IoT双通道框架
Jingyi Lin,Kaiian Kuok,Wengioi Mio et al.
Jingyi Lin et al.
Age-associated microglial heterogeneity includes emergence of mobile microglial states [0.03%]
与年龄相关的微胶质细胞异质性包括活性微胶质细胞状态的出现
Sunitha Subhramanian,Olga Bocharova,Olga Mychko et al.
Sunitha Subhramanian et al.
Microglia maintain neuronal homeostasis through dynamic surveillance strategies that depend on their functional state. In the healthy brain, highly ramified microglia monitor neuronal integrity via motile processes and transient soma contac...
Baseline facial emotion recognition is associated with clinical decline across the Alzheimer's disease spectrum: a multi-instrument longitudinal assessment study [0.03%]
基线面部情绪识别与阿尔茨海默病全病程的临床衰退有关：一项纵向多指标评估研究
YongSoo Shim,Eun Ye Lim
YongSoo Shim
Background: Facial emotion recognition (FER) is increasingly recognized as a functionally relevant domain in the Alzheimer's disease (AD) spectrum, yet whether baseline FER is associated with subsequent clinical decline r...
The amino acid substitutions A30W, K28A, and M35C alter amyloid-β peptide toxicity in cell culture and in an in vivo model of amyloidosis in Caenorhabditis elegans [0.03%]
氨基酸替代物A30W，K28A和M35C可改变细胞培养以及秀丽隐杆线虫淀粉样变病模型中淀粉状-β肽的毒性
Diana Patricia Quijano-Guerrero,Ana Esther Estrada-Rodríguez,Mauricio Caballero-Rodríguez et al.
Diana Patricia Quijano-Guerrero et al.
The buildup of toxic aggregates formed by the amyloid-β peptide 1-42 (Aβ42) is a central process in Alzheimer's disease (AD) pathology. The peptide's self-assembly and toxicity are highly dependent on its primary amino acid sequence and c...
Social cognition in Parkinson's disease: a comprehensive systematic review and integrative conceptual framework [0.03%]
帕金森病的社会认知：全面系统回顾与整合概念框架
Maor Yeshua,Elise Klein,Martin Südmeyer et al.
Maor Yeshua et al.
Introduction: Parkinson's disease (PD) is characterized not only by motor symptoms but also by non-motor impairments, including deficits in social cognition (SC), defined as the ability to recognize, interpret, and respon...
The role of exercise intensity in motor and non-motor symptoms of Parkinson's disease: mechanisms, clinical evidence, and personalized exercise prescription parameters [0.03%]
运动强度在帕金森病运动和非运动症状中的作用：机制、临床证据及个性化运动方案参数建议
Zhiwei Zhang,Yang Zhou
Zhiwei Zhang
Parkinson's disease (PD) is the second most common neurodegenerative disorder, featuring progressive dopaminergic neuronal loss, Lewy body (LB) pathology, and a broad spectrum of motor and non-motor symptoms. Although dopaminergic pharmacot...
Generic vs. brand-name pramipexole: effectiveness, safety, and cost comparison in a multicenter retrospective cohort study [0.03%]
普拉克索仿制药与品牌药的效果、安全性和成本比较：一项基于多中心回顾性队列的研究
Ke Wang,Xiaoxuan Xing,Zhizhou Wang et al.
Ke Wang et al.
Background: Generic pramipexole is widely prescribed for Parkinson's disease (PD), yet clinical equivalence to the brand-name formulation remains debated. We aimed to compare generic and brand-name pramipexole dihydrochlo...
Motor performance and 3D gait pattern characteristics in older adult women with early mild cognitive impairment: a pilot study [0.03%]
轻度认知障碍老年女性的运动表现和三维步态模式特征：一项试点研究
Ho-Jong Gil,Jongbin Kim
Ho-Jong Gil
Introduction: Early mild cognitive impairment (eMCI) is often accompanied by subtle alterations in motor function and gait control before the onset of overt dementia. Identifying these early functional changes may provide...