Multimodal imaging and machine learning for diagnosis of Parkinson's disease with cognitive impairment: ASL and QSM as potential biomarkers [0.03%]
多模态影像和机器学习在帕金森病伴认知障碍诊断中的应用及ASL和QSM的生物标志物价值研究
Weimin Qi,Jiang Cheng,Xiuping Zhan et al.
Weimin Qi et al.
Objectives: This study aimed to investigate differences in brain imaging characteristics among patients with Parkinson's disease with cognitive impairment (PDCI), Parkinson's disease without cognitive impairment (PDNCI), and healthy control...
Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study [0.03%]
缺血性卒中老年人认知功能转归及影响因素纵向研究分析
Xinhao Chen,Chengxia Wei,Danli Zhao et al.
Xinhao Chen et al.
Background and purpose: Accurately defining cognitive function trajectories in elderly ischemic stroke patients is crucial for identifying high-risk groups for cognitive decline, enabling timely personalized interventions...
Older adult solitary drinking: associations with subjective and objective cognitive functioning [0.03%]
独居老年人饮酒与主观认知功能和客观认知功能的关系
Carillon J Skrzynski,Angela D Bryan
Carillon J Skrzynski
Background: Solitary drinking is a pattern of hazardous alcohol consumption that is problematic at any age but is more prevalent in older adults, yet most research focuses on younger samples. Research on solitary drinking...
Intrinsic mechanical vibrations as a missing dimension in amyloid- β clearance: a mechanochemical hypothesis for Alzheimer's disease [0.03%]
淀粉样蛋白-β清除中内在机械振动这一缺失维度：阿尔茨海默病的机械化学假说
Xiaochen Lai
Xiaochen Lai
Alzheimer's disease is widely viewed as a disorder of disturbed amyloid-β (Aβ) homeostasis, yet it remains unclear why Aβ shifts from routine turnover to progressive retention and plaque growth in mid-life. This article advances a mechan...
Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID [0.03%]
肠道屏障功能障碍、病毒持续存在和免疫失调在长新冠的神经后遗症中汇聚
Laurence Leclerc,Johanne Poudrier,Christopher Power et al.
Laurence Leclerc et al.
Long COVID (LC) is a multisystem, post-infectious conditions diagnosed ≥3 months after acute SARS-CoV-2 infection and marked by relapsing, persistent, or progressive symptoms, especially fatigue, post-exertional symptom exacerbation and ne...
Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies [0.03%]
人巨细胞病毒感染与认知能力下降：来自人群和实验研究的见解
Koon Chu Yaiw,Isidre A Ferrer,Cecilia Söderberg-Nauclér et al.
Koon Chu Yaiw et al.
Human cytomegalovirus (HCMV), a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through...
White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment [0.03%]
轻度行为异常对白质高信号与晚年认知关系的调节作用分析
Jiayu Duan,Ningqun Wang,Shixin Li et al.
Jiayu Duan et al.
Background: Mild behavioral impairment (MBI) is recognized as a potential early marker for dementia and may be indicative of the increased risk in the predementia stage. This study investigated whether MBI could moderate ...
Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease [0.03%]
从机制到药物：阿尔茨海默病药物再定位策略综述
Sara Akhtar Khan,Khushi Raza,Prachi Tiwari et al.
Sara Akhtar Khan et al.
Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In ...
Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study [0.03%]
基于纵向EEG数据预测由遗忘性轻度认知障碍向阿尔茨海默病发展：一项为期12个月队列研究
Yingfeng Ge,Yi Fei,Chonglong Ding et al.
Yingfeng Ge et al.
Introduction: Amnestic mild cognitive impairment (aMCI), serving as a clinical precursor to Alzheimer's Disease (AD), assumes a pivotal role in the early stages of AD prevention. The longitudinal collection of data in aMC...
Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer's disease [0.03%]
基于非适应性神经可塑性假说的阿尔茨海默病治疗和预防策略
Shigeki Kawabata
Shigeki Kawabata
Alzheimer's disease (AD), the most common form of dementia, is characterized by two hallmark pathologies, amyloid plaques (APs) and neurofibrillary tangles (NFTs). Amyloid-β and tau, key components of APs and NFTs, respectively, are widely...