The amino acid substitutions A30W, K28A, and M35C alter amyloid-β peptide toxicity in cell culture and in an in vivo model of amyloidosis in Caenorhabditis elegans
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The buildup of toxic aggregates formed by the amyloid-β peptide 1-42 (Aβ42) is a central process in Alzheimer's disease (AD) pathology. The peptide's self-assembly and toxicity are highly dependent on its primary amino acid sequence and can be altered by m... ...
