Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats [0.03%]
Hany A Elkattawy,Mohamed El-Sherbiny,Nehal Elsherbiny et al.
Hany A Elkattawy et al.
Background: Sleep is a fundamental biological process essential for maintaining mental, emotional, and physical health. Chronic sleep deprivation (SD), particularly in aging, is associated with oxidative stress, neuroinfl...
Andrzej Przekwas,Carly Norris,Harsha T Garimella
Andrzej Przekwas
The use of mechanistic models to support personalized medicine and precision diagnostics offers transformative potential for neurology. In this study, we developed a mechanistic model of Alzheimer's Disease progression (mAD) that integrates...
APOE genotypes are associated with the level of naturally occurring antibodies to amyloid- β in patients with Alzheimer's disease [0.03%]
Janardan P Pandey,Aryan M Namboodiri,Franca Rosa Guerini et al.
Janardan P Pandey et al.
Apolipoprotein E ε4 (APOEε4) allele is the strongest known genetic risk factor for Alzheimer's disease (AD). Mechanisms underlying this association are incompletely understood. We aimed to determine whether APOE genotypes influenced the l...
Brittany A Klub,Andrew F Teich,Giuseppe P Cortese
Brittany A Klub
Epileptic activity and neuronal excitability have been reported in the setting of Alzheimer's disease (AD), and may be linked to disease progression and severity. A shift in the excitation/inhibition balance to favor a more excitatory-domin...
Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: a systematic review and network meta-analysis [0.03%]
Youxue Tu,Changmei Lu,Bao Wu et al.
Youxue Tu et al.
Objectives: Parkinson's disease (PD) patients frequently develop mild cognitive impairment (PD-MCI) and may progress to Parkinson's disease dementia (PDD). Despite progress in understanding PD pathophysiology, reliable bl...
Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging [0.03%]
Fan Guo,Jiapei Chi
Fan Guo
Astaxanthin (AST), a xanthophyll carotenoid derived from microalgae and marine organisms, has emerged as a potent neuroprotective compound with remarkable antioxidant and anti-inflammatory properties. Growing evidence indicates that AST can...
Neural correlates of prospective memory in Parkinson's disease: a high-density EEG study [0.03%]
帕金森病前瞻性记忆的神经相关性：一次高密度脑电图研究
Paola Santacesaria,Stefano Vicentin,Giorgia Cona
Paola Santacesaria
Introduction: Prospective memory (PM), the ability to remember and execute intended actions in the future, is a critical component of daily functioning and independent living, particularly in individuals with Parkinson's ...
Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes [0.03%]
帕金森病及其运动亚型的纹状体-丘脑-皮层和小脑-丘脑-皮层网络的体积标志物
Fatemeh Sadeghi,Abdullah Okar,Ronak Rashedi et al.
Fatemeh Sadeghi et al.
Introduction: Parkinson's disease (PD) is a systems-level disorder, implicating basal ganglia-thalamo-cortical (BTC) and cerebello-thalamo-cortical (CTC) networks. While regional atrophy has been reported, network-wide vo...
Focused ultrasound enhances targeted curcumin delivery and alleviates behavioral and neuropathological deficits in a Parkinson's disease mouse model [0.03%]
聚焦超声增强靶向姜黄素递送并缓解帕金森病小鼠模型的行为和神经病理缺陷
Shu-Mei Yang,Sen-Hi Yeoh,Meng-Ting Lin et al.
Shu-Mei Yang et al.
Introduction: Curcumin exhibits potent neuroprotective properties but is limited by poor blood-brain barrier (BBB) permeability. This study aimed to evaluate whether focused ultrasound (FUS)-mediated BBB opening enhances ...
Katherine M Andersh,Michael MacLean,Gareth R Howell et al.
Katherine M Andersh et al.
Introduction: A growing body of literature suggests a role for neuroinflammation in retinal ganglion cell (RGC) death in glaucoma. For instance, deficiency of three proinflammatory cytokines, complement component 1, subco...