Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation [0.03%]
大鼠模型围绝经期认知障碍的分子机制：多组学整合揭示Adgrl2-Camk2d-TRPV1信号轴介导钙稳态紊乱和神经炎症
Wen Wang,Shouhui Chai,Xianming Yin et al.
Wen Wang et al.
Background: Perimenopause represents a pivotal transitional stage in female reproductive aging, often accompanied by neurological disorders such as cognitive decline. However, the underlying molecular mechanisms remain in...
Multivariate associations between systemic inflammation, metabolic dysregulation, and cognitive performance in project FRONTIER [0.03%]
基于PROJECT FRONTIER项目系统性炎症、代谢紊乱和认知表现的多变量关联分析
Chathurika S Dhanasekara,Chanaka N Kahathuduwa,Volker Neugebauer
Chathurika S Dhanasekara
Background: Cognitive aging is heterogeneous, and growing evidence implicates chronic low-grade inflammation and metabolic dysregulation in neuropathology and cognitive decline. This study examined the multivariate relati...
Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies [0.03%]
阿尔茨海默病相关感觉障碍的神经炎症：机制联系、可操作靶点和治疗策略
Yanjiao Xu,Guimei Zhang,Xinran Cui et al.
Yanjiao Xu et al.
Alzheimer's disease (AD) is the most common cause of dementia and major public-health challenge in aging societies worldwide. Accumulating evidence suggests that olfactory and visual deficits can precede overt cognitive symptoms and are clo...
PredatorNet: a clinically trustworthy deep learning framework for multi-class Alzheimer's disease classification using MRI [0.03%]
基于MRI的多分类阿尔茨海默病临床可信深度学习框架PredatorNet
T Deenadayalan,S P Shantharajah
T Deenadayalan
MRI-based staging of Alzheimer's Disease (AD) requires not only high classification accuracy but also clinically reliable probability estimates, transparent evidence for decisions, and robustness to shifts in data distribution. We propose P...
Ultrasound-guided brachial plexus hydrodissection combined with acupotomy release for the treatment of cervical spondylotic radiculopathy: a multicenter retrospective study [0.03%]
超声引导下肱丛液离术结合刃针松解治疗颈椎病根性痛的多中心回顾性研究
Xiang Shang,Guo-Rui Luan,Yang-Chun Song et al.
Xiang Shang et al.
Introduction: The incidence of cervical spondylotic radiculopathy (CSR) remains high. Conventional conservative treatments have limited efficacy in relieving mechanical nerve root compression, while surgery is highly inva...
Dopamine D3 receptor blockade restores hippocampal synaptic plasticity and rescues memory deficits in Alzheimer's disease mouse models [0.03%]
多巴胺D3受体阻断可恢复阿尔茨海默病小鼠模型的海马突触可塑性并挽救记忆缺陷
Maria Rosaria Tropea,Giuseppe Aceto,Roberta Carmela Trovato et al.
Maria Rosaria Tropea et al.
Introduction: Early synaptic failure is widely considered a primary driver of cognitive decline in Alzheimer's disease (AD), and previous studies have suggested that dopaminergic signaling may contribute to hippocampal sy...
Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities [0.03%]
衰老过程中炎症和血脑屏障功能障碍在认知老化中的作用：机制、生物标志物及治疗机会
Fan Bu,Shulin Zeng,Zhengchi Lou et al.
Fan Bu et al.
Age-related cognitive decline is increasingly recognised as arising from interacting immune and neurovascular vulnerabilities rather than from isolated insults. In this Review, we synthesise current human and mechanistic evidence within a c...
Petra Bago Rožanković,Goran Šimić
Petra Bago Rožanković
Early and accurate diagnosis of Parkinson's disease (PD) remains a challenge, hindering the efficient recruitment of patients into clinical trials aimed at disease modification. This underscores the urgent need for validated and clinically ...
Correction: Chrono-combined aerobic-resistance exercises as therapeutic approach to reverse neurodegeneration in rat model: a detailed protocol [0.03%]
纠正：作为治疗方案逆转大鼠模型神经退行性病变的chrono-联合有氧抗阻运动：详细的方案
Muhammad Hafiz Zuhdi Fairof,Hussin Muhammad,Amirul Hafiz Ahmad Abdullah et al.
Muhammad Hafiz Zuhdi Fairof et al.
[This corrects the article DOI: 10.3389/fnagi.2026.1775321.]. Keywords: chrono-exercise; combined aerobic-re...
Published Erratum
Frontiers in aging neuroscience. 2026 Jul 13:18:1889952. DOI:10.3389/fnagi.2026.1889952 2026
Correction: Neuroimaging insights into lung disease-related brain changes: from structure to function [0.03%]
关于肺部疾病相关脑改变的神经影像学见解：从结构到功能（勘误）
Zhixi Zhang,Miao He,Yubo Liu et al.
Zhixi Zhang et al.
[This corrects the article DOI: 10.3389/fnagi.2025.1550319.]. Keywords: MRI-based brain changes; lung diseas...
Published Erratum
Frontiers in aging neuroscience. 2026 Jul 13:18:1923503. DOI:10.3389/fnagi.2026.1923503 2026