The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration [0.03%]
循环BDNF水平及其多态性在年龄相关认知障碍和神经退行性疾病中的预测潜力
Tatiana V Tulupova,Maria V Vedunova,Elena V Mitroshina
Tatiana V Tulupova
Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, synaptic plasticity, and cognitive function. Age-related decline in BDNF signaling has been implicated in the pathogenesis of Alzheimer's disease, Parkinson's dise...
Effect of increasing cognitive activity participation via calligraphy practice on salient network and central executive network in older adults with subjective cognitive decline: a secondary analysis of a randomized controlled trial [0.03%]
基于随机对照试验的二次分析：通过练习书法增加认知活动参与对主观认知下降老年人显著网络和中央执行网络的影响
Jing Li,Yishan Luo,Zhaohua Huo et al.
Jing Li et al.
Objectives: Regular participation in late-life cognitive activities is associated with a reduced risk of dementia. In a prior randomized controlled trial, we demonstrated that increased calligraphy practice improved worki...
Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study [0.03%]
老年性听力损失患者的脑结构协变网络改变：基于磁共振成像的大样本形态学研究证据
Qi Yan,Ying Wang,Li Xu et al.
Qi Yan et al.
Background: Presbycusis is characterized by progressive age-related hearing loss and is often associated with cognitive decline and mental health disorders. ...
Nurse-led non-pharmacological interventions for cognitive improvement in dementia patients: a systematic review and meta-analysis of randomized controlled trials [0.03%]
以护士为主导的非药物干预改善痴呆患者认知功能：系统评价和meta分析
Jie Zhang,Rong Luo,Jialei Chen
Jie Zhang
Introduction: Nurse-led non-pharmacological interventions (NLNPIs) have gradually been recognized as a safe strategy to improve cognitive function in patients with dementia. Nevertheless, current research findings remain ...
AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease [0.03%]
基于人工智能的多模态神经影像在正常衰老和年龄相关性疾病中的应用——用于神经递质定位映射
Paige Hewitt,Hongsheen Kim,Thomas A Vida
Paige Hewitt
Aging reshapes neurotransmitter systems through nonlinear and region-specific shifts that alter excitatory-inhibitory balance, weaken metabolic coupling, and destabilize large-scale neural networks. PET, MRS, molecular MRI, and optical imag...
Nilima Nilima,Hina Narzari,Shubham Gupta et al.
Nilima Nilima et al.
Introduction: Population-specific normative data are essential for accurately interpreting cognitive test performance, particularly in low-resource settings characterized by low literacy rates. In India, normative values ...
Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis [0.03%]
脑源性神经营养因子与术后各阶段认知功能障碍的关联：系统回顾和荟萃分析
Danyan Liang,Xiaodong Wang,Yi Qiu
Danyan Liang
Postoperative cognitive dysfunction (POCD) is a frequent complication after surgery, particularly among older adults, and its underlying mechanisms remain incompletely understood. Brain-derived neurotrophic factor (BDNF) is a key regulator ...
The Vall d'Hebron Initiative for Parkinson (VHIP) cohort: a prospective, longitudinal, and observational study enrolling de novo Parkinson's disease patients for biomarker identification and validation [0.03%]
巴塞罗那卫尔德龙帕金森病（VHIP）队列研究：一项前瞻性纵向观察性研究，纳入新发帕金森病患者以识别和验证生物标志物
Daniela Samaniego,Silvia Enríquez-Calzada,Laura Domingo et al.
Daniela Samaniego et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing a variety of motor and non-motor symptoms. To date, no disease modifying treatment exists, and diagnosis is based on the manifestati...
Ferroptosis-related biomarkers for diagnosis and mechanistic insights into Alzheimer's disease [0.03%]
与阿尔茨海默病诊断和机制相关的铁死亡生物标志物
Mingchen Zhao,Xinlu Sui,Jieming Li et al.
Mingchen Zhao et al.
Background: Alzheimer's disease (AD) lacks reliable early diagnostic biomarkers and effective disease-modifying therapies. Ferroptosis has been increasingly implicated in AD pathogenesis; however, ferroptosis-related gene...
The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer's disease: an exploratory study [0.03%]
长期抗癫痫治疗对晚期发作性阿尔茨海默病认知下降的影响：一项探索性研究
Benjamin Cretin,Nathalie Philippi,Olivier Bousiges et al.
Benjamin Cretin et al.
Background: The well-documented bidirectional relationship between Alzheimer's disease (AD) and epilepsy suggests that seizures are not merely a complication of AD but may also contribute to disease progression. Emerging ...