Brain insulin resistance: a key pathological hub linking metabolic and neuropsychiatric comorbidities [0.03%]
Shanwen Tang,Yifan Liao,Maoyi Yang et al.
Shanwen Tang et al.
The high rate of comorbidity between metabolic diseases and neuropsychiatric disorders suggests a shared underlying pathogenic mechanism. However, the biological basis of this relationship remains unclear. This study aims to clarify the rol...
Privacy and personalisation: predicting Parkinson's disease severity from real-world gait with federated learning [0.03%]
Chloe Hinchliffe,Hugo Hiden,Lisa Alcock et al.
Chloe Hinchliffe et al.
Introduction: Cloud-based artificial intelligence (AI) combined with smart-health technology presents a powerful tool to passively monitor disease severity. However, current methods raise privacy concerns as they require ...
Livia Scanferla,Atbin Djamshidian
Livia Scanferla
Impulse control disorders (ICDs), such as excessive gambling, compulsive sexual behavior, binge eating, compulsive shopping as well as punding, and the dopamine dysregulation syndrome, may arise as a debilitating neuropsychiatric complicati...
Prolonged intermittent theta burst stimulation enhances hippocampal plasticity via GluN2A-mediated signaling [0.03%]
Danica Popovic,Marina Zaric Kontic,Milica Zeljkovic Jovanovic et al.
Danica Popovic et al.
Background: Intermittent theta burst stimulation (iTBS) is increasingly explored as a non-invasive neuromodulatory approach capable of inducing long-lasting plasticity with potential therapeutic value in age-related neuro...
Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults [0.03%]
Mary Brooks,Randa El Chami,Hugo R Jourde et al.
Mary Brooks et al.
Introduction: Sleep quality is often thought to be a key determinant of cognitive performance, particularly in older adults who experience age-related changes in sleep architecture. However, the extent to which nightly va...
Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review [0.03%]
Celest Wen Ting Seah,Matthias Ho,Collin Chu et al.
Celest Wen Ting Seah et al.
Background: Age is a major risk factor for ischemic stroke (IS), with immunosenescence-age-related immune system dysfunction - contributing to worse outcomes. Immunosenescence impairs immune responses, heightens inflammat...
Novel applications of machine learning and computational neuroscience models to neuroimaging in Parkinson's disease and related disorders [0.03%]
Lydia Chougar,Andrew Vo,Stéphane Lehéricy et al.
Lydia Chougar et al.
Purpose of review: Parkinsonian syndromes are a heterogeneous group of neurodegenerative diseases that pose challenges in early diagnosis, differentiation, and pathophysiological understanding. The objective of this revie...
Interconnected roles of astrocytes and the blood-brain barrier in Parkinson's disease: pathological evidence, mechanistic insights, and knowledge gaps [0.03%]
Anna C Stoll,Ashley S Harms
Anna C Stoll
Parkinson's disease (PD) has long been defined by α-synuclein aggregation and dopaminergic neurodegeneration, yet growing evidence indicates that non-neuronal contributors, specifically astrocytes and the blood-brain barrier (BBB), may pla...
Association of gait, balance, and handgrip strength with cognitive performance in hospitalized older adults: a retrospective analysis [0.03%]
Deng-Peng Wen,Xiao Liu,Tian Gan et al.
Deng-Peng Wen et al.
Background: Sensorimotor impairments-such as reduced gait speed, diminished balance, and lower muscle strength-are common in older adults and have been suggested as early markers of cognitive decline. However, evidence fr...
Serum proteomics reveals biomarkers for diagnosis, stratification, and mechanistic insights into cerebral microbleeds [0.03%]
Wu-Meng Yin,Liu-Chang He,Guang-Yi Han et al.
Wu-Meng Yin et al.
Objective: Cerebral microbleeds (CMBs) are small vascular lesions detectable on MRI and are associated with increased stroke risk and cognitive decline. However, imaging-based diagnosis is limited by cost and accessibilit...