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Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation

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Background: Perimenopause represents a pivotal transitional stage in female reproductive aging, often accompanied by neurological disorders such as cognitive decline. However, the underlying molecular mechanisms remain incomplete... ...