Pyroptosis regulated by m6A modification: implications for pyroptosis-related disease therapy [0.03%]
由m6A修饰调控的细胞焦亡及其疾病治疗意义
Yujun Zhou,Bo Wei,Sihan Chen et al.
Yujun Zhou et al.
Pyroptosis is a lytic and inflammatory form of programmed cell death that is typically initiated by inflammasome activation and executed by gasdermin proteins. It is characterized by cellular swelling, plasma membrane perforation, and the r...
Giorgos Marinakis,Eleni Karakike,Panagiotis Koufargyris et al.
Giorgos Marinakis et al.
Introduction: Biomarkers to predict response of critical COVID-19 to tocilizumab (TCZ) are under investigation. Serum levels of interleukin (IL)-6 and IL-6 soluble receptors were studied in a cohort of patients all receiv...
Insights into neutrophil dysfunction in inherited metabolic disorders [0.03%]
遗传性代谢障碍中中性粒细胞功能障碍的研究进展
Anja Wolf,Giulia Montanelli,Déborah Mathis et al.
Anja Wolf et al.
Background: Inherited metabolic disorders (IMDs) often manifest with defects in neutrophil development, function, or survival, resulting in recurrent severe infections and elevated morbidity. Although neutropenia and immu...
Streptococcus pyogenes infection and CD4+ T cells crosstalk promote an antigen-presenting cell-like phenotype in neutrophils [0.03%]
化脓链球菌感染和CD4⁺T细胞信号促进中性粒细胞向抗原呈递细胞表型转化
Anna Riegner,Nikolai Siemens
Anna Riegner
Introduction: Neutrophils are the most abundant leukocytes in human blood and a key component of host defense against Streptococcus pyogenes (group A streptococci, GAS). They are rapidly recruited to the site of infection...
Ryan Flannery,Rory Baird,Debananda Gogoi et al.
Ryan Flannery et al.
Cystic fibrosis (CF) is a hereditary disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The major causes of morbidity and mortality in CF are related to lung disease, involving neutrophil-do...
Increased bacterial load per neutrophil reduces intracellular killing capacity [0.03%]
每个中性粒细胞内的细菌负荷增加会降低其胞内杀菌能力
Louise V Duebel,Simon O Dekker,Suzanne H Bongers et al.
Louise V Duebel et al.
Introduction: Neutrophils are the most abundant innate immune cells in the peripheral blood and eliminate bacteria through phagocytosis and antimicrobial mechanisms. Early during infection, they often encounter high bacte...
NEUTROPHIL INFLAMMASOME ACTIVATION AND PYROPTOSIS INDUCED BY A METALLOPROTEINASE VIA HIF-1α AND GASDERMIN D PATHWAYS [0.03%]
铁死亡诱导的中性粒细胞炎性小体激活和焦亡：HIF-1α和GSDMD依赖的新机制
Milena Daniela Souza Silva,Carolina Pereira da Silva,Vanessa Ferreira de Araujo et al.
Milena Daniela Souza Silva et al.
Bothrops jararacussu venom contains snake venom metalloproteinases (SVMPs) that contribute to inflammation and tissue damage. BjussuMP-II, a PI-class SVMP, lacks hemorrhagic activity but retains proteolytic and immunomodulatory properties. ...
Respiratory syncytial virus nonstructural protein 1 inhibits production of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface [0.03%]
呼吸道合胞病毒非结构蛋白1通过抑制气液界面培养的分化人原代鼻上皮细胞中的细胞因子和趋化因子的产生来抑制干扰素信号通路
Rosanne W Koutstaal,Amadeo Munoz Garcia,Nadine Ebert et al.
Rosanne W Koutstaal et al.
Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and older adults. Currently approved vaccines target only the viral fusion protein, but live-attenuated vaccines - e.g. through inactivation of ...
Marie Piollet,Jana Grune,Clément Cochain
Marie Piollet
Background: Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide. Neutrophils have emerged as actors in non-infectious pathologies and play major roles in cardiovascular disea...
Editors' Choice 2025 Journal of Innate Immunity - From Receptor Proximal Training to Metabolic and Fibrotic Control [0.03%]
2025年先天免疫期刊主编精选-从受体近端训练到代谢和纤维化调控
Catherine M Greene,Emer P Reeves
Catherine M Greene