The small ubiquitin-like modifier SUMO-3 acts as a neutrophil chemoattractant via the chemokine receptors CXCR1 and CXCR2 [0.03%]
泛素样修饰蛋白SUMO-3通过化学引诱剂受体CXCR1和CXCR2吸引中性粒细胞
Sean P Giblin,Vlad Razvan Moiseanu,Christina Josephine Carrington et al.
Sean P Giblin et al.
Introduction: Small ubiquitin-like modifiers (SUMOs) are small peptides conjugated to proteins during post-translational modification which have been reported to modulate several aspects of the immune system, notably in a...
Neutrophil CEACAMs and the inflammatory response to Neisseria gonorrhoeae [0.03%]
中性粒细胞CEACAM与淋球菌的炎症反应关系研究
Mary W Broden,Alexandra Torres Maisonet,Alison K Criss
Mary W Broden
Background: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are proteins that mediate intercellular adhesion, intracellular signaling, and microbial recognition. Of the CEACAMs made by human neutrophils...
Beyond the Neutrophil Count: Functional Profiling and Targeted Modulation of Neutrophils in Paediatric Care [0.03%]
超越中性粒细胞计数：儿科护理中的中性粒细胞功能谱分析及靶向调节
James Trayer,Lynne A Kelly,Eoghan Dunlea et al.
James Trayer et al.
Background Neutrophils are the most abundant leukocyte in childhood and form a critical component of innate immunity, particularly in early life when adaptive responses are still maturing. In paediatrics, both quantitative and qualitative d...
Neutrophil killing of Peptoanaerobacter stomatis requires TAK1-driven degranulation [0.03%]
TAK1驱动的脱颗粒作用对中性粒细胞杀灭Peptoanaerobacter stomatis至关重要
Shikha Srivastava,Aruna Vashista,Abidemi Ruth Idowu et al.
Shikha Srivastava et al.
Introduction: Dysregulated neutrophil functions play a crucial role in the onset and progression of periodontitis. Peptoanaerobacter stomatis is an emerging oral bacterium associated with periodontitis and is known to act...
Neutrophil dynamics in viral infections: drivers of inflammation and targets for pro-resolving therapies [0.03%]
病毒感染中的中性粒细胞动力学：炎症驱动因素及促解决疗法的作用靶点
Filipe Resende,Felipe Emanuel Oliveira Rocha,Celso Martins Queiroz-Junior et al.
Filipe Resende et al.
Background: Neutrophils are essential components of host defense, traditionally recognized for their well-described antimicrobial functions in bacterial infections. Far from being merely short-lived and functionally limit...
In vivo cytokine adsorption reveals distinct neutrophil mobilization pathways during experimental human endotoxemia [0.03%]
体内细胞因子吸附显示在实验性人类内毒素血症期间中性粒细胞动员途径不同
Suzanne H Bongers,Bernard N Jukema,Aron Jansen et al.
Suzanne H Bongers et al.
Introduction: During acute inflammation, such as experimental human endotoxemia, circulating neutrophil counts initially decrease followed by pronounced neutrophilia. Banded (CD16dim/CD62Lbright) and hypersegmented (CD16b...
Laura A Novotny,Carla Martinez-Morant,Stephen A Duncan et al.
Laura A Novotny et al.
Background: Lambda interferons signal through the interferon lambda receptor-1 (IFNLR1) and IL10RB heterodimer to induce interferon stimulated genes (ISGs). We previously showed that proteins derived from distinct IFNLR1 ...
Association of CD32-131H>R Polymorphism with End-Stage COPD and Interstitial Lung Diseases [0.03%]
CD32-131H>R多态性与终末期COPD和间质性肺病的关联研究
Sarah M Berger,Laura M Kühner,Ines M Schwarzinger et al.
Sarah M Berger et al.
Introduction: Progression to end-stage lung diseases is influenced by both environmental and genetic factors, yet predictive markers remain limited. The CD32-131H>R polymorphism in the FCGR2A gene alters the affinity of t...
Smad2/3 regulates IL-6R m6A methylation through METTL3 to influence inflammatory responses in hemorrhoidal disease [0.03%]
Smad2/3通过METTL3调节IL-6R m6A甲基化以影响痔病炎症反应
Chunling Li,Xu Han,Aili Chen et al.
Chunling Li et al.
Objective: This study investigates METTL3's function and mechanisms in hemorrhoidal disease-related inflammation. Methods: A rat model ...
Exploring the role of neutrophils in pathogenesis of lymphangioleiomyomatosis [0.03%]
探讨中性粒细胞在淋巴管肌瘤病发病机制中的作用
Donal O Apos Malley,Katie Ann Doran,Cormac McCarthy
Donal O Apos Malley
Background Lymphangioleiomyomatosis (LAM) is a rare, slowly progressive neoplasm, predominantly affecting women, characterized by the presence of diffuse cystic lung disease. Its pathogenesis is driven by mutations in tuberous sclerosis com...