Daily photoprotection mitigates seasonal skin changes and supports skin longevity: a one-year in vivo 3D multiphoton microscopy study [0.03%]
每日防晒可缓解季节性皮肤变化并支持皮肤长久活力：一年内活体三维多光子显微镜研究
Edouard Raynaud,Barbara Lynch,Blandine Ngo et al.
Edouard Raynaud et al.
Background: While the detrimental effects of intense sun exposure are well-recognized, the cumulative impact of daily moderate UV exposure remains less explored. This year-long study investigated the effects of seasonal v...
Philip Wesley Wertz,Joachim W Fluhr
Philip Wesley Wertz
Background: Atopic dermatitis (AD) is a common remitting-relapsing inflammatory skin disease characterized by eczematous lesions, xerosis and pruritis. It is associated with a defective permeability barrier and increased ...
Methods to detect antioxidants and free radicals in human skin and its applications with focus on Asian skin [0.03%]
应用于亚洲皮肤的抗氧化剂和自由基检测方法及其应用
Li Chen,Alexandra Lan,Yifan He et al.
Li Chen et al.
The interaction between antioxidants and free radicals has become increasingly important in cosmetic research. This review is not a conventional literature overview but is primarily based on our own experimental data and methodological deve...
Simulated Microgravity Suppresses Proline Biosynthesis in Skin Fibroblasts to Impair Skin Structure [0.03%]
模拟微重力通过抑制皮肤成纤维细胞中脯氨酸生物合成来破坏皮肤结构
Wenbin Wang,Xiufen Peng,Qing Luo et al.
Wenbin Wang et al.
Introduction: Microgravity during spaceflight is increasingly associated with cutaneous impairment, yet the structural basis and underlying metabolic mechanisms remain poorly defined. Collagen, the main component of the d...
Multiphoton tomography of micro- and nanocosmetics in human skin: in vivo studies in volunteers and patients with ex vivo validation [0.03%]
多光子层析技术在人体皮肤中对微纳米化妆品的研究：志愿者和患者的临床试验及体外验证
Ana Carolina Henriques Ribeiro Machado,Yousuf Mohammed,Michael S Roberts et al.
Ana Carolina Henriques Ribeiro Machado et al.
Background: A holy grail in human skin permeation is to be able to quantify how compounds and nanoparticles are absorbed, distributed and exert their effects. Traditionally, the processes used have either been destructive...
A molecular-dynamics-guided screening pipeline identifies topical glucocorticoid receptor modulators with selective epidermal activation [0.03%]
基于分子动力学的筛选流程发现了具有选择性表皮激活作用的外用糖皮质激素受体调节剂
Feng-Chuan Tai,Heng-Hui Lien,Shih-Chang Lin et al.
Feng-Chuan Tai et al.
Introduction: Topical corticosteroids remain the mainstay of psoriasis management but are limited by skin atrophy and barrier impairment. Developing safer, steroid-sparing therapy represents an unmet need in topical pharm...
Regional cutaneous vasodilatory responses to local heating in post-menopausal females with and without hormone replacement therapy [0.03%]
局部加热引起的绝经后妇女区域性皮肤血管舒张反应（激素替代疗法在内）
Caroline Li-Maloney,Gregory W McGarr,Sarah J I Johnson et al.
Caroline Li-Maloney et al.
We investigated whether post-menopausal females receiving hormone replacement therapy (HRT) exhibit greater nitric oxide (NO)-dependent cutaneous microvascular responses than those not receiving HRT, assessed via pharmacological NO synthase...
Novel glyceryl ascorbate derivatives inhibit type 2 alarmin cytokine induction and promote expression of epidermal barrier function-related factors in human keratinocytes in vitro [0.03%]
新型甘油抗坏血酸衍生物抑制体外人角质形成细胞Ⅱ型报警元细胞因子诱导并促进皮肤屏障功能相关因素的表达
Shunya Sahara,Natsuki Wakita,Miki Iwai et al.
Shunya Sahara et al.
Atopic dermatitis is characterized by the interplay among type 2 immune responses, skin barrier dysfunction, and pruritus. Despite the pivotal role of interleukin-33 in the pathogenesis of the disease, novel therapeutic strategies remain li...
Network Pharmacology, Molecular Docking, Hematological Evaluation, and In Vivo Evidence Support Sakuranetin as a Redox and Inflammation-Modulating Agent Against Skin Tumorigenesis [0.03%]
网络药理学、分子对接、血液学评估和体内证据表明山萘酚是一种调节皮肤肿瘤发生的红氧活性和炎症调节剂
Humood Al Shmrany,Abdulkarim S Binshaya
Humood Al Shmrany
Introduction: Skin cancer is a growing global health concern, often linked to environmental carcinogens like ultraviolet radiation and chemicals. This study investigated the protective effects of sakuranetin against DMBA-...
Human skin responses to UV (predominantly UVC at 254 nm) irradiation - in vivo kinetics of morphological changes and recovery using non-invasive two-photon tomography [0.03%]
紫外线（主要为254纳米的UVC）辐照后的人体皮肤反应：使用非侵入式双光子层析成像技术研究形态变化和恢复的体内动力学规律
Tatiana B Lepekhina,Viktor V Nikolaev,David A Lopez Guardado et al.
Tatiana B Lepekhina et al.
Introduction: The effects of ultraviolet (UV) radiation on the skin are manifold. On the one hand, it aids in the production of vitamin D and is used in phototherapy. On the other hand, it can cause cell damage leading to...