Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities [0.03%]
一类具有抗肿瘤活性的苯并噻唑类维甲酸X受体拮抗剂的合成与生物活性研究
Yingting Lin,Ming Peng,Renjing Yang et al.
Yingting Lin et al.
Retinoid X receptor α (RXRα) plays a vital role in multiple biological and pathological processes and represents a promising therapeutic target for anti-tumor drug design. Inspired by the marine-derived RXRα antagonist meroterpenthiazole...
Meat Nutritional Value and Exoskeleton Valorisation of Callinectes sapidus from Three Sites of Biological and Ecological Interest in Morocco: Scientific Insights Toward a Management Strategy in the Mediterranean Sea [0.03%]
摩洛哥三个具有生物和生态价值的地点的蓝蟹Callinectes sapidus营养价值及外骨骼高值化：地中海海域管理策略的科学见解
Kamal Gourari,Youness Mabrouki,Abdelkhaleq Fouzi Taybi et al.
Kamal Gourari et al.
Biological invasions threaten biodiversity worldwide. The American blue crab Callinectes sapidus Rathbun, 1896, among the Mediterranean's most damaging invaders, takes up the challenge to transform this threat into gain. To turn its impact ...
Effect of Precipitated Extracellular Marennine on Angiogenesis and Tumour Cell Proliferation [0.03%]
萃取墨酚对血管生成和肿瘤细胞增殖的影响
Mostefa Fodil,Javier Muñoz-Garcia,Amel-Khitem Benali et al.
Mostefa Fodil et al.
Angiogenesis is a fundamental biological process involved in the formation of new blood vessels from the pre-existing vascular network. In addition to physiological processes, angiogenesis is also implicated in pathological conditions such ...
Extraction of Marine Bioactive Compounds from Seaweed: Coupling Environmental Concerns and High Yields [0.03%]
兼顾环保和高产出的海洋褐藻活性化合物提取研究
Carlos Cardoso,Joana Matos,Cláudia Afonso
Carlos Cardoso
This review examines recent advances in the extraction of valuable compounds from seaweed biomass, focusing on practical feasibility and environmental sustainability. There is a growing importance of seaweed biomass in terms of the study an...
Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy [0.03%]
新型的pH响应性的负载PSS的壳聚糖基质纳米颗粒可改善压力超负荷引起的心脏肥大
Meijie Xu,Zhen Fan,Dingfu Wang et al.
Meijie Xu et al.
Cardiac hypertrophy is a critical contributor to cardiac dysfunction and the development of heart failure, yet effective therapeutic strategies remain limited. Propylene glycol alginate sulfate sodium (PSS) is a marine sulfated polysacchari...
Mariana Rodrigues Santos,Bárbara Joana Henriques,Romana Santos
Mariana Rodrigues Santos
The formation of amyloid-like structures is commonly linked to neurodegenerative diseases, such as Parkinson's and Alzheimer's. However, proteins can form amyloid-like structures in non-pathological contexts, referred to as functional amylo...
Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101 [0.03%]
基于组学的深海链霉菌活性卤化代谢产物的发现与鉴定
Emmanuel Tope Oluwabusola,Stephen A Jackson,Cristina Brunati et al.
Emmanuel Tope Oluwabusola et al.
Using the one-strain-many-compounds (OSMAC) culturing approach, metabolomic studies, and bioassay-guided purification, we have isolated and characterised three new chlorinated natural products, agelolines B-D (1-3), together with two known ...
Enhancing Phycoerythrin Production of Marine Red Microalga Porphyridium purpureum with Low Salinity and Semi-Continuous Culture Strategy [0.03%]
利用低盐度和半连续培养策略提高海洋红微藻Porphyridium purpureum中聚球菌红色素的产量
Chulin Li,Houbo Wu,Hualian Wu et al.
Chulin Li et al.
Porphyridium purpureum can synthesize a high phycoerythrin content, which has strong potential application in nutrition, pharmaceuticals, and cosmetics. An effective culture strategy is the key to producing biomass of P. purpureum rich in p...
Co-Culture of Auxenochlorella protothecoides and Serratia liquefaciens Promotes Lutein Accumulation [0.03%]
Auxenochlorella protothecoides和Serratia liquefaciens共培养促进叶黄素积累
Weiwei Xue,Zhen Li,Yanhong Qiu et al.
Weiwei Xue et al.
Lutein, a crucial carotenoid with diverse biological roles, is in high demand in the market. Current production predominantly relies on plant extraction, which is hindered by low yield and seasonal limitations. Microalgae, such as Chlorella...
Contamination Characteristics of 21 PFAS in Shellfish and Crustaceans of Zhejiang Province and Exposure Risk Assessment for Adult Dietary Consumers [0.03%]
浙江省贝类和甲壳类中21种PFAS污染特征及成人消费者的暴露风险评估
Hexiang Zhang,Haoyi Zhang,Ronghua Zhang et al.
Hexiang Zhang et al.
This study investigated the occurrence, sources, and health risks of 21 per- and polyfluoroalkyl substances (PFAS) in commercially available shellfish and crustaceans from Zhejiang Province, China. Among the 306 samples analyzed, 87.9% cont...