Exploring Biosurfactant Production from Halophilic Bacteria, Isolated from Burgas Salterns in Bulgaria [0.03%]
保加利亚布尔加斯盐沼中极端嗜盐菌生物表面活性剂的产生及其特性研究
Kaloyan Berberov,Ivanka Boyadzhieva,Boryana Yakimova et al.
Kaloyan Berberov et al.
Biosurfactants produced by halophilic bacteria are gaining attention as eco-friendly and biocompatible alternatives to synthetic surfactants due to their high surface activity, stability under extreme conditions, and intrinsic antimicrobial...
Marine Bromophenols from Laminaria hyperborea's Epiphytic Biomass: Chemical Profiling, Cytotoxicity, and Antioxidant Activity [0.03%]
铜藻附生生物量中卤代酚的化学成分、细胞毒性和抗氧化活性研究
Angeliki Barouti,Vinh Le Ba,Lars Herfindal et al.
Angeliki Barouti et al.
The epiphytic community of Laminaria hyperborea, dominated by red algae, is typically discarded during industrial processing despite its potential as a source of high-value natural products. This study aims to valorize this underutilized bi...
Isolation, Structural Elucidation, and Biological Evaluation of Pyrrole-Based Alkaloids from Sea Anemone-Associated Streptomyces sp. S1502 [0.03%]
来源于海葵相关链霉菌S1502中的吡咯类生物碱的分离鉴定及生物活性研究
Xin Zhang,Qihong Yang,Le Zhou et al.
Xin Zhang et al.
Three new pyrrole alkaloids, streptopyrroles D-F (1-3), along with four known analogs (4-7) were isolated from Sea Anemone-Associated Streptomyces sp. S1502 via an OSMAC (One Strain Many Compounds)-based strategy. Their structures were eluc...
Aptamer-Based Dual-Cascade Signal Amplification System Lights up G-Quadruplex Dimers for Ultrasensitive Detection of Domoic Acid [0.03%]
基于适配体的双重级联信号放大系统点亮G-四重奏二聚物以实现超灵敏检测石房蛤毒素
Jiansen Li,Zhenfei Xu,Zexuan Zhang et al.
Jiansen Li et al.
In recent years, harmful algal blooms have led to frequent occurrences of shellfish toxin contamination, posing a significant threat to the safety of aquatic products and public health. As a potent neurotoxin, domoic acid (DA) can accumulat...
Acute Intravenous Astaxanthin Administration Modulates Hyperexcitability in Rat Nociceptive Secondary Sensory Neurons Induced by Inflammation [0.03%]
急性注射虾青素可调节炎症诱导的伤害性感觉神经元的高兴奋性
Risako Chida,Mamoru Takeda
Risako Chida
Previous in vivo studies have clearly demonstrated that the intravenous administration of the carotenoid astaxanthin (AST) suppresses the excitability of rat trigeminal spinal nucleus caudalis (SpVc) neurons. This action is hypothesized to ...
Design and Synthesis of Marine Sarocladione Derivatives with Potential Anticancer Activity [0.03%]
具抗肿瘤活性海洋Sarocladione衍生物的合成与鉴定
Xiao-Mei Liu,Wen-Xuan Li,Ling-Xiu Kong et al.
Xiao-Mei Liu et al.
The discovery of structurally novel anti-tumor agents remains a crucial objective in cancer drug research. In this study, we systematically explored the bioactivity potential of sarocladione (5), a structurally unique marine-derived 14-memb...
A Novel Bis-Spiroketal Scaffold and Other Secondary Metabolites from the Marine-Derived Fungus Talaromyces stipitatus HF05001: Structural Diversity and Bioactivities [0.03%]
一种新的双倍*spiroketal*骨架及从海洋衍生型*Talaromyces stipitatus HF05001*真菌中获得的其他次级代谢产物：结构多样性与生物活性
Longhe Yang,Yan Qiu,Ying Liu et al.
Longhe Yang et al.
Marine-derived fungi have become a vital resource for the discovery of novel secondary metabolites with diverse structures and significant biological activities. This study focuses on a systematic chemical investigation of the sponge-associ...
Truncated Equinin B Variants Reveal the Sequence Determinants of Antimicrobial Selectivity [0.03%]
截短的Equinin B变异体揭示了抗菌选择性的序列决定因素
Mariele Staropoli,Theresa Schwaiger,Jasmina Tuzlak et al.
Mariele Staropoli et al.
Equinin B (GQCQRKCLGHCSKKCPKHPQCRKRCIRRCFGYCL), a marine peptide from Actinia equina exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. To identify a smaller active region and explore tunable properties, ...
Recombinant Expression and Antimicrobial Mechanism of Cysteine-Rich Antimicrobial Peptides from Tigriopus japonicus Genome [0.03%]
日本虎鲸缨鳃壳纤毛虫基因组中半胱氨酸丰富的抗菌肽的重组表达及抗菌机制研究
Dan Pu,Hongwei Tao,Jingwei Pang et al.
Dan Pu et al.
The misuse of antibacterial agents has contributed to the growing prevalence of antibiotic resistance, highlighting an urgent need to explore alternative anti-infection therapeutic strategies. Antimicrobial peptides (AMPs) are naturally occ...
Marine Bacteria as a Source of Antibiotics Against Staphylococcus aureus: Natural Compounds, Mechanisms of Action, and Discovery Strategies [0.03%]
海洋细菌作为抗金黄色葡萄球菌抗生素的来源：天然化合物、作用机制和发现策略
Céphas Xuma,Alexandre Bourles,Julien Colot et al.
Céphas Xuma et al.
Staphylococcus aureus is a major opportunistic pathogen responsible for a wide spectrum of human infections, including severe and difficult-to-treat cases. The emergence of multidrug-resistant strains limits the efficacy of conventional ant...