Stability of p53 oligomers: Tetramerization of p53 impinges on its stability [0.03%]
p53寡聚物的稳定性：p53四聚化影响其稳定性
Johnson Wahengbam Luwang,Aadithye R Nair,Ramanathan Natesh
Johnson Wahengbam Luwang
The p53 protein has been known to exist structurally in three different forms inside the cells. Earlier studies have reported the predominance of the lower oligomeric forms of p53 over its tetrameric form inside the cells, although only the...
Kristyna Krasulova,Peter Illes
Kristyna Krasulova
Human gut is in permanent contact with microorganisms that play an important role in many physiological processes including metabolism and immunologic activity. These microorganisms communicate and manage themself by the quorum sensing syst...
Fractionating stem cells secretome for Parkinson's disease modeling: Is it the whole better than the sum of its parts? [0.03%]
帕金森病建模中分离诱导多能干细胞分泌组分的研究：整体优于部分之和吗？
Helena Vilaça-Faria,Ana Marote,Inês Lages et al.
Helena Vilaça-Faria et al.
Human mesenchymal stem cells (hMSCs) secretome has been have been at the forefront of a new wave of possible therapeutic strategies for central nervous system neurodegenerative disorders, as Parkinson's disease (PD). While within its protei...
Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model [0.03%]
人源group IIA分泌型磷脂酶A2在疟疾病理生理中的作用：来自转基因小鼠模型的启示
Mélanie Dacheux,Soraya Chaouch,Alonso Joy et al.
Mélanie Dacheux et al.
We previously showed that injection of recombinant human group IIA secreted phospholipase A2 (hGIIA sPLA2) to Plasmodium chabaudi-infected mice lowers parasitaemia by 20%. Here, we show that transgenic (TG) mice overexpressing hGIIA sPLA2 h...
CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion [0.03%]
管腔型雄激素受体乳腺癌细胞系中exo CD151的富集有助于细胞侵袭
Dan Li,Wenjia Lai,Qingsong Wang et al.
Dan Li et al.
Breast cancer is the most common and highly heterogeneous disease in women worldwide. Given the challenges in the treatment of advanced metastatic breast cancer, it is necessary to understand the molecular mechanisms related to disease prog...
Coronaviruses, cholesterol and statins: Involvement and application for Covid-19 [0.03%]
冠状病毒、胆固醇和他汀类药物：涉及应用及对新冠肺炎的治疗作用
Stéphane Orlowski,Jean-Jacques Mourad,Antonio Gallo et al.
Stéphane Orlowski et al.
The infectious power of coronaviruses is dependent on cholesterol present in the membranes of their target cells. Indeed, the virus enters the infected cell either by fusion or by endocytosis, in both cases involving cholesterol-enriched me...
Soluble resistance-related calcium-binding protein participates in multiple diseases via protein-protein interactions [0.03%]
一种可溶性抗阻力相关钙结合蛋白通过蛋白质-蛋白质相互作用参与多种疾病病理过程
Yinmiao Wang,Yuanyuan Zhu,Zhangya Pu et al.
Yinmiao Wang et al.
Soluble resistance-related calcium-binding protein (sorcin), a 22 kDa penta-EF-hand protein, has been intensively studied in cancers and multidrug resistance over a prolonged period. Sorcin is widely distributed in tissues and participates ...
Grapevine aquaporins: Diversity, cellular functions, and ecophysiological perspectives [0.03%]
葡萄糖转运蛋白：多样性、细胞功能和植物生理生态学视角
Farzana Sabir,Olfa Zarrouk,Henrique Noronha et al.
Farzana Sabir et al.
High-scored premium wines are typically produced under moderate drought stress, suggesting that the water status of grapevine is crucial for wine quality. Aquaporins greatly influence the plant water status by facilitating water diffusion a...
Smita Verma,Velayutham Ravichandiran,Nihar Ranjan
Smita Verma
Thioflavin T (ThT) is a commercially available fluorescent dye that is commonly used in biomedical research for over five decades. It was first reported as an extrinsic fluorescent probe for the detection of amyloid fibrils and related proc...
Aspartic protease-pepstatin A interactions: Structural insights on the thermal inactivation mechanism [0.03%]
天冬氨酸蛋白酶-肽统计A相互作用：热失活机制的结构见解
Kavya Purushothaman,Sagar Krishna Bhat,Shiva Siddappa et al.
Kavya Purushothaman et al.
Aspartic proteases are the targets for structure-based drug design for their role in physiological processes and pharmaceutical applications. Structural insights into the thermal inactivation mechanism of an aspartic protease in presence an...