Effects of head group substitution on large antiviral polyamide-DNA binding kinetics [0.03%]
头部基团取代对大型抗病毒聚酰胺-脱氧核糖核酸结合动力学的影响
Jacquelyn Niederschulte,Yang Song,Terri G Edwards et al.
Jacquelyn Niederschulte et al.
Hairpin polyamides are pyrrole-based polymers that bind in the minor groove of DNA with remarkable affinity and specificity. While the natural product netropsin that inspired PA design features a terminal guanidinium group, few studies have...
Small heat shock proteins in plants: Structure, function and role in stress adaptation [0.03%]
植物中的小热休克蛋白：结构、功能及其在胁迫适应中的作用
Santanu Mondal,Md Azaharuddin,Rakhi Dasgupta
Santanu Mondal
Small heat shock proteins (sHSPs) are a diverse group of ATP-independent molecular chaperones that play a vital role in maintaining protein stability in plants under stress conditions. Defined by a conserved α-crystallin domain, these prot...
A novel chondroitinase AC from the marine bacterium Vibrio sp. ZLC12: Biochemical characterization, degradation pattern, and products properties [0.03%]
来自海洋细菌的新型硫酸软骨素AC外切酶ZLC12：生化特性、降解模式及产物性质
Wenwen Wang,Yuliang Xu,Yameng Zhu et al.
Wenwen Wang et al.
Chondroitinases AC are vital for preparing chondroitin sulfate (CS) oligosaccharides and studying structure-activity relationships. In this study, a novel chondroitinase AC (ZL1) from marine Vibrio sp. ZLC12 was heterologously expressed in ...
Structural conservation, functional decline: The fate of human OHCU decarboxylase [0.03%]
结构上的保守性与功能的退化：人类OHCU脱羧酶的命运
Júlia T Rodrigues,Mozart S Pereira,Lucas Bleicher et al.
Júlia T Rodrigues et al.
The conversion of uric acid to (S)-allantoin is catalyzed by urate oxidase (uricase), 5-hydroxyisourate hydrolase (HIUase), and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCUd). In hominids, including Homo sapiens, these ...
Nanoplastic-driven white pollution: Biochemical insights into ecosystem and human health impacts - a critical-interpretative narrative review [0.03%]
纳米塑料驱动的白色污染：生态系统和人类健康影响的生化见解——批判性诠释综述
Matheus Naia Fioretto,Natália Magosso,Patrick Vieira de Souza et al.
Matheus Naia Fioretto et al.
Plastic production has become a global challenge, and its accelerated growth and widespread waste release justify the characterization of the current era as the "Age of Plastic". The concern is how additives or plastic degradation can impac...
Aptamers as therapeutic tool against oxidative and inflammatory intermediaries of astrocytes in neurological disorders: Current paradigms, perspective, future directions and challenges [0.03%]
针对神经元疾病中氧化和炎症介质的适配子疗法：现状、展望、未来方向及挑战
Sakshi Goswami,Yeshvandra Verma,Nickolay K Isaev et al.
Sakshi Goswami et al.
Astroglia, often called as astrocytes, play a crucial role in protecting neurons and preserved the neurophysiological functions. Astrocytes' dysfunction contributes to numerous neurological disorders. Astrocytes are involved in the regulati...
Engineering aminoacyl-tRNA synthetase activity to enhance branched-chain amino acid biosynthesis [0.03%]
工程化 Charging Enzyme 活性以增强支链氨基酸生物合成
Alice S Derunets,Alexander S Yanenko
Alice S Derunets
Branched-chain amino acids (BCAA; valine, leucine, and isoleucine) are high-value metabolites. Its microbial production can be significantly increased by metabolic engineering. While pathway engineering dominates current efforts, the BCAA-s...
Pallavi Juneja,Supriya Tanwar,Rana Zaidi et al.
Pallavi Juneja et al.
CARD9 is a key adaptor protein involved in innate immune signaling and plays a vital role in defending the host against fungal, bacterial, and viral infections. Its activation triggers downstream pathways that promote cytokine production an...
Priyanka Brahmachary,Emelia A Keim,Seth T Walk et al.
Priyanka Brahmachary et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that integrates environmental, microbial, and metabolic signals to regulate gene expression across diverse tissues. Recent studies highlight AhR's role in skelet...
Advancing subunit vaccine efficacy against ricin toxin with a novel DNA hydrogel adjuvant tandem assembly by CpG motifs [0.03%]
新型CpG基序DNA水凝胶佐剂递呈里芬毒素亚单位疫苗诱导高效保护性免疫反应
Xiao Geng,Chengbiao Sun,Kaikai Yu et al.
Xiao Geng et al.
The development of effective countermeasures against ricin toxin, a potent biological threat, remains a pressing public health challenge. Subunit vaccines based on the ricin toxin A subunit offer a favorable safety profile but often suffer ...