Structural conservation, functional decline: The fate of human OHCU decarboxylase
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The conversion of uric acid to (S)-allantoin is catalyzed by urate oxidase (uricase), 5-hydroxyisourate hydrolase (HIUase), and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCUd). In hominids, including Homo sapiens, these enzymes are generall... ...