Aerobic exercise attenuates sarcopenia-related changes via TXNIP-associated modulation of apoptosis, inflammation and autophagy [0.03%]
有氧运动通过TXNIP相关调节凋亡、炎症和自噬减轻肌肉减少症相关变化
Xiaoqin Zhao,Qianyu Chen,Jiaqi You et al.
Xiaoqin Zhao et al.
Sarcopenia is an age-related syndrome characterized by progressive loss of skeletal muscle mass, strength, and function, and represents a major challenge to healthy aging. Thioredoxin-interacting protein (TXNIP) has been associated with ske...
Gut-Derived Uremic Toxin Indoxyl Sulfate and Aryl Hydrocarbon Receptor in Renal Osteodystrophy [0.03%]
肠道尿毒症毒素吲哚硫酸与肾病骨病中的芳香烃受体
Carl Ralph Russell rd,Neal Chen,Annabel Biruete et al.
Carl Ralph Russell rd et al.
Chronic kidney disease (CKD) affects 14% individuals worldwide. Changes in bone and mineral metabolism in CKD are ubiquitous (CKD- Mineral and Bone Disorder) including renal osteodystrophy with a fracture incidence of up to 5 times greater ...
Mapping Hofmeister Cation and Anion Effects on Seeded and Unseeded Aggregation of TDP-43 and Amyloid-β in Micelle-Assisted Seed Amplification [0.03%]
霍夫迈斯特阳离子和阴离子对米胶囊辅助种子放大法中TDP-43和淀粉样蛋白-β聚集的种子介导和无种子介导聚集的影响映射图
Naoki Yamahara,Yusuke Nakanishi,Akuto Tahara et al.
Naoki Yamahara et al.
Seed-amplification assays (SAA) amplify trace protein aggregates and are being developed for early diagnosis of neurodegenerative diseases. We previously demonstrated that the addition of Brij-58 micelles markedly increases the sensitivity ...
Novel statin derivatives as non-competitive inhibitors of human adenylate kinase 1: synthesis, enzyme inhibition, molecular docking, and biological studies [0.03%]
新型他汀衍生物作为人腺苷酸激酶1非竞争性抑制剂的研究：合成，酶抑制，分子对接及生物研究
Anna Kozakiewicz-Piekarz,Magdalena Grzegórska,Maja Mielcarz et al.
Anna Kozakiewicz-Piekarz et al.
Adenylate kinases (AKs) are a family of conserved phosphotransferases essential for maintaining cellular energy homeostasis through the interconversion of adenine nucleotides. AKs also contribute to diverse pathophysiological processes beyo...
Influence of Ions, pH and Crowding Agents on Structure and Stability of PIM1 Secondary Structures [0.03%]
离子、pH和拥挤剂对PIM1二级结构的影响
İrem Göller,Saba Orouji,Özgül Persil Çetinkol
İrem Göller
Triple Negative Breast Cancer (TNBC) is an aggressive subtype of a breast cancer defined by the absence of ER, PR and HER-2 receptors. The lacking of these receptors limits the availability of the targeted therapy options. The recent identi...
Discovery of ferroptosis drugs targeting SLC7A11/BECN1 based on living cell quantitative FRET imaging [0.03%]
基于活细胞FRET成像技术发现靶向SLC7A11/BECN1的铁死亡药物
Zhiyu Xiao,Ziru Wu,Miao Tan et al.
Zhiyu Xiao et al.
This study aims to establish a method to discover ferroptosis drugs targeting the SLC7A11/BECN1 interaction based on live-cell quantitative fluorescence resonance energy transfer (FRET) imaging. In MDA-MB-231 cells, Imidazole Ketone Erastin...
Proteomic Profiling Reveals Region-Specific Neuroimmune and Apoptotic Signatures Induced by Bothrops jararaca Venom Toxins in the Murine Brain [0.03%]
基于蛋白质组学分析的布棕毒蛇毒素诱导小鼠脑区域特异性神经免疫及凋亡反应
Julia O Alkmin,Jorge C Moschem,Alison F A Chaves et al.
Julia O Alkmin et al.
Human envenomation by Bothrops species can lead to systemic effects such as cardiovascular disturbances, coagulopathy, renal failure, and central nervous system (CNS) complications, including hemorrhagic and ischemic strokes. Although Bothr...
Physicochemical modulation of FapC amyloid assembly redirects rhamnolipid production in Pseudomonas fluorescens CHA0 [0.03%]
调节荧光假单胞菌(Pseudomonas fluorescens)CHA0中FapC淀粉样蛋白组装可重新导向鼠李糖脂的产生
Nishita G Master,Anoop R Markande,Janki Patel
Nishita G Master
Protein self-assembly and surface-active metabolites govern microbial interfacial behavior and extracellular functionality. In Pseudomonas fluorescens CHA0, the functional amyloid protein FapC assembles into highly ordered β-sheet-rich fib...
Dexamethasone- and rapamycin-mediated mitochondrial dysfunction occurs independently of altered Yin Yang 1 expression in C2C12 myotubes [0.03%]
糖皮质激素和雷帕霉素介导的线粒体功能障碍独立于C2C12肌管中Yin Yang 1表达改变发生
Alexa J Klein,Kipton B Travis,John M Zimmerman et al.
Alexa J Klein et al.
Skeletal muscle is an indispensable tissue and loss of skeletal muscle mass and function can severely impact quality of life. Dexamethasone-treated C2C12 myotubes are an increasingly common model for studying skeletal muscle pathology (such...
Directed evolution of a thermostable laccase from Geobacillus stearothermophilus for efficient reduction of oxygen [0.03%]
一种耐热漆酶的定向进化使其能高效还原氧气
Bipasa Dey,Cini M Suresh,Shilpi Singh et al.
Bipasa Dey et al.
The growing demand for laccases with enhanced stability and high redox potential is driven by their potential applications in diverse bioelectrochemical processes. Bacterial laccases are generally more stable than their fungal counterparts ...