Insights into the structure and function of the C-terminus of SGTs (small glutamine-rich TPR-containing proteins): A study of the Aedes aegypti homolog [0.03%]
SGTs(C端富含谷氨酰胺TPR蛋白)的结构和功能研究——以埃及伊蚊同源序列为例
Natália G Quel,Luiz Fernando de C Rodrigues,Annelize Z B Aragão et al.
Natália G Quel et al.
SGTs (small glutamine-rich TPR-containing proteins) are dimeric proteins that belong to the class of co-chaperones characterized by the presence of TPR domains (containing tetratricopeptide repeats). Human (SGTA) and yeast (Sgt2) SGTs are c...
Modification of DNA regions with metagenomic DNA fragments (MDRMDF): A convenient strategy for efficient protein engineering [0.03%]
利用宏基因组DNA片段改良DNA区域开展高效蛋白质工程的一种简便策略 MDRMDF可以修改DNA区域以进行有效的蛋白质工程
Shumin Xu,Xianghui Qi,Song Gao et al.
Shumin Xu et al.
In this study, we have established a convenient and efficient approach named Modification of DNA Regions with Metagenomic DNA Fragments (MDRMDF) for protein engineering. Degenerate primers were designed corresponding to conserved regions of...
Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange [0.03%]
利用HN/H2O(D2O)交换表征临床相关galectin-1的配体诱导构象变化
Andreas Schedlbauer,Ulrich Gilles,Anna-Kristin Ludwig et al.
Andreas Schedlbauer et al.
Glycans of cellular glycoconjugates serve as biochemical signals for a multitude of (patho)physiological processes via binding to their receptors (e.g. lectins). In the case of human adhesion/growth-regulatory galectin-1 (Gal-1), small angl...
Matilde Forcella,Marta Manzoni,Giuliana Benaglia et al.
Matilde Forcella et al.
Zebrafish encodes several sialidases belonging to the NEU3 group, the plasma membrane-associated member of the family with high specificity toward ganglioside substrates. Neu3.1, Neu3.2 and Neu 3.3 have been expressed in E. coli and purifie...
Dynamics of the canonical RNA degradosome components during glucose stress [0.03%]
葡萄糖胁迫下经典RNA降解体组分的动力学变化
Marcos Emmanuel Jaso-Vera,Lilianha Domínguez-Malfavón,Everardo Curiel-Quesada et al.
Marcos Emmanuel Jaso-Vera et al.
The RNA Degradosome (RNAD) is a multi-enzyme complex, which performs important functions in post-transcriptional regulation in Escherichia coli with the assistance of regulatory sRNAs and the RNA chaperone Hfq. Although the interaction of t...
Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells [0.03%]
Rbfox2介导人肝癌细胞中胰岛素受体原初始转录本的外显子11剪接入侵断
Takahito Nakura,Atsufumi Ozoe,Yuka Narita et al.
Takahito Nakura et al.
Insulin receptor (IR) pre-mRNA undergoes alternative splicing that produces two isoforms, IR-A and IR-B. The ratio of IR-A to IR-B varies among tissues, which strongly suggests that IR mRNA alternative splicing is regulated in a tissue-spec...
A combinatorial in silico approach for microRNA-target identification: Order out of chaos [0.03%]
一种用于确定微小核糖核酸靶基因的组合式计算机方法：杂乱中的有序
Km Taufiqul Arif,Rachel K Okolicsanyi,Larisa M Haupt et al.
Km Taufiqul Arif et al.
Contemporary computational microRNA(miRNA)-target prediction tools have been playing a vital role in pursuing putative targets for a solitary miRNA or a group of miRNAs. These tools utilise a set of probabilistic algorithms, machine learnin...
Regulation of bone metastasis and metastasis suppressors by non-coding RNAs in breast cancer [0.03%]
非编码RNA调控乳腺癌骨转移及抑制转移机制研究进展
G Sanjeev,S Pranavkrishna,R L Akshaya et al.
G Sanjeev et al.
Breast cancer (BC) is a critical health care issue that substantially affects women worldwide. Though surgery and chemotherapy can effectively control tumor growth, metastasis remains a primary concern. Metastatic BC cells predominantly col...
Functional analysis of Lsm protein under multiple stress conditions in the extreme haloarchaeon Haloferax mediterranei [0.03%]
多重胁迫条件下极端嗜盐古菌Haloferax mediterranei中Lsm蛋白的功能分析
Gloria Payá,Vanesa Bautista,Mónica Camacho et al.
Gloria Payá et al.
The Sm, like-Sm, and Hfq proteins belonging to the Sm superfamily of proteins are represented in all domains of life. These proteins are involved in several RNA metabolism pathways. The functions of bacterial Hfq and eukaryotic Sm proteins ...
Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein [0.03%]
人、穿山甲、猫和蝙蝠ACE2与SARS-CoV-2刺突蛋白受体结合域相互作用的分子模拟研究
Shaojie Ma,Hui Li,Jun Yang et al.
Shaojie Ma et al.
The recent outbreak of SARS-CoV-2 has had a profound effect on the world. Similar to that in SARS-CoV, the entry receptor of SARS-CoV-2 is ACE2. The binding of SARS-CoV-2 spike protein to ACE2 is the critical to the virus infection. Recentl...