Polyphenol-rich fraction of Bergenia ligulata regresses colon and breast cancer metastasis by cell-type specific mechanism [0.03%]
牻牛儿苗环黄酮通过细胞类型特异性机制逆转结肠和乳腺癌转移
Samhita De,Somesh Roy,Suvranil Ghosh et al.
Samhita De et al.
Background: Colon and breast cancer are among the leading causes of mortality worldwide. The limited efficacy of current treatments highlighted an urgent need for improved therapeutic options. Bergenia ligulata, known for...
Quercetin attenuates chondrocyte anoikis via modulation of mesenchymal stromal cell-derived small extracellular vesicles to promote cartilage repair in osteoarthritis [0.03%]
檞皮素通过调节间充质基质细胞源性小细胞外囊泡缓解软骨细胞脱离诱导的凋亡以促进关节炎软骨修复
Feng Cheng,Haotian Hua,Yiwen Zhu et al.
Feng Cheng et al.
Background: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degeneration and impaired repair. Current therapies are unable to effectively slow its progression, and there is an urgent need to...
Evidences for action of icariin on depressive behavior in prenatal stress offspring rats and mechanism by integrating metabolomics and network pharmacology [0.03%]
基于网络药理学和代谢组学整合的淫羊藿苷对母体应激大鼠子代抑郁行为作用及机制研究
Yankai Dong,Wei Liu,Jinqiang Cheng et al.
Yankai Dong et al.
Background: Depression, as a prevalent and persistent mental disorder, poses a significant load for people and the community. Given the limitations of conventional antidepressant drugs, including their adverse side effect...
Asiaticoside alleviates atherosclerosis progression by suppressing RhoF-NF-κB/MAPK signaling and inflammation in macrophages [0.03%]
Asiaticoside通过抑制RhoF-NF-κB / MAPK信号传导和巨噬细胞中的炎症来缓解动脉粥样硬化的发展
Junlu Wang,Lingli Lei,Shasha Wang et al.
Junlu Wang et al.
Background: Asiaticoside (AT), a triterpenoid derived from Centella asiatica, has long been recognized for its anti-inflammatory properties. Its potential to ameliorate atherosclerosis (AS), a chronic inflammatory disease...
Huanglian Wendan decoction alleviates metabolic syndrome by reprogramming macrophage polarization: Evidence from multi-omics integration [0.03%]
黄连温胆汤通过重新编程巨噬细胞极化来缓解代谢综合征：多组学整合证据
Zuqing Su,Yanlin Li,Zihao Zhou et al.
Zuqing Su et al.
Background: The prevalence of metabolic syndrome has shown a progressive rise, while contemporary pharmacological treatments are often associated with significant adverse effects. Huanglian Wendan Decoction (HLWD), a trad...
Xiao Sheng,Jianzheng He,Lei Zhang
Xiao Sheng
Background: Bioactive natural compounds have made significant contributions to health and medicine due to their therapeutic properties, yet they remain a vastly untapped resource in the quest for novel therapeutic agents....
Maslinic acid alleviates ulcerative colitis by inhibiting the colitis-aggravating pathogen Clostridium perfringens and modulating gut microbiota [0.03%]
maslinic酸通过抑制加重炎症性肠病的病原体梭状芽孢杆菌并调节肠道微生物群来缓解溃疡性结肠炎
Bailu Geng,Congmin Zhu,Zilu Cui et al.
Bailu Geng et al.
Background: Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease, continues to pose therapeutic challenges due to the limitations of conventional drugs and their inability to prevent relapse. Emerging e...
Capture the superior anti-osteoporotic innovative multi-component complex from Ligustri Lucidi Fructus based on Component Recombination strategy [0.03%]
基于组分重组策略从女贞子中捕获抗骨质疏松症的创新型多成分复方研究
Jun Jiang,Baixiu Zhao,Yuwen Ma et al.
Jun Jiang et al.
Background: Postmenopausal osteoporosis (PMOP) was accompanied by iron overload and low levels of calcium (Ca), phosphorus (Pi) and magnesium (Mg), which required downregulating iron and upregulating Ca/Pi/Mg simultaneous...
Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice [0.03%]
辣椒素通过调节FXR-SHP和FXR-FGF15肠肝轴改善胆汁淤积
Hui Du,Yue Luo,Ning Zhou et al.
Hui Du et al.
Background: Cholestasis, including primary sclerosing cholangitis (PSC), remains a challenging condition with limited treatment options. The gut-liver axis and FXR signaling pathways play critical roles in maintaining bil...
Unlocking the gut-lung axis: Feixin decoction as a novel modulator in hypoxic pulmonary hypertension [0.03%]
揭秘肠肺轴：菲菌散治疗缺氧性肺动脉高压的全新机制研究
Fei-Ying Wang,Jian Yi,Ling-Ling Zhou et al.
Fei-Ying Wang et al.
Background: Feixin decoction (FXD) is an effective traditional Chinese medicine prescription for treating chronic pulmonary heart disease and hypoxic pulmonary hypertension (HPH), However, the pharmacological mechanism of...