3-n-Propionyl Zaluzanin C from Saussurea involucrata alleviates inflammation and oxidative stress: potential involvement of the NRF2 signaling pathway [0.03%]
短叶乌头茋类成分3-n-丙酰紫斑素C通过激活NRF2信号通路减轻炎症和氧化应激
Lianting Liang,Bodou Zhang,Juntao Liu et al.
Lianting Liang et al.
Background: Inflammation and oxidative stress are core pathological processes in the development of numerous chronic diseases, mutually reinforcing each other to create a vicious cycle. Consequently, identifying natural c...
Spermidine alleviates sepsis-induced cardiomyopathy by improving mitochondrial quality and quantity via a Metallothionein 1-dependent antioxidant pathway [0.03%]
spermidine通过金属硫蛋白1依赖性抗氧化途径改善线粒体质量和数量从而缓解脓毒症诱导的心肌病
Shiyun Long,Jiaxin Sun,Yaguang Wu et al.
Shiyun Long et al.
Background: Sepsis-induced cardiomyopathy (SICM) is characterized by mitochondrial dysfunction, impaired mitophagic flux, and overwhelming oxidative stress. Spermidine (SPD), a natural polyamine known to enhance autophagy...
Effect of Yiqi Fumai lyophilized injection on B-type natriuretic peptide levels in patients with acute decompensated ischemic heart failure: a multicenter, open-label, blinded-outcome, randomized controlled trial [0.03%]
益气复脉冻干粉针改善缺血性心力衰竭患者B型利钠肽水平的疗效：一项多中心、开放性、设盲终点、随机对照试验
Xianliang Wang,Zhiqiang Zhao,Jingyuan Mao et al.
Xianliang Wang et al.
Background: Patients with acute decompensated ischemic heart failure (ADIHF) often present with severe clinical symptoms and poor quality of life. In China, Yiqi Fumai lyophilized injection (YQFM) is widely used in the tr...
Momordin Ic targets SREBP1 to disrupt lipid homeostasis and trigger synergistic apoptosis-ferroptosis in triple-negative breast cancer [0.03%]
momordin Ic靶向SREBP1以破坏脂质稳态并触发三阴性乳腺癌的协同凋亡-铁死亡反应
Yao Cheng,Yu-Zhe Shi,Jia-Yi Zheng et al.
Yao Cheng et al.
Background: Triple-negative breast cancer (TNBC) constitutes a clinically challenging disease subtype characterized by high metastatic potential and unsatisfactory treatment outcomes. Developing innovative pharmacological...
Chromones from Saposhnikovia divaricata modulate m6A RNA methylation-mediated macrophage polarization by targeting CBLL1 to ameliorate RA [0.03%]
防风中的黄酮类化合物通过靶向CBLL1调节m6A介导的巨噬细胞极化改善RA病理损伤
Xu Yang,Zhichao Hao,Shiqi Xu et al.
Xu Yang et al.
Background: Over-activated M1 macrophages, which destroyed the balance of macrophage phenotype in the synovial microenvironment, play a pivotal role in rheumatoid arthritis (RA) progression. Increasing evidence indicates ...
Jingfang granules alleviate atopic dermatitis by restoring skin barrier function and inhibiting NF-κB/NLRP3 axis and JAK/STAT3 axis [0.03%]
荆防颗粒通过修复皮肤屏障及抑制NF-κB/NLRP3轴和JAK/STAT3轴治疗特应性皮炎
Yi Tai,Shen Cao,Weiwei Zhong et al.
Yi Tai et al.
Background: Atopic dermatitis (AD) is a recurrent inflammatory disease that significantly impacts patients' quality of life. Jingfang Granules (JFG) have been employed in the therapeutic management of AD and psoriasis (PS...
Friedelin suppresses osteoclastogenesis via sequential dual-targeting of p105 processing and STAT3-mediated metabolic reprogramming [0.03%]
friedelin通过依次靶向p105加工和STAT3介导的代谢重组来抑制破骨细胞生成
Xuanrui Zhang,Biao Yang,Xiaoyu Ma et al.
Xuanrui Zhang et al.
Background: Pathological osteolysis, driven by excessive osteoclast activity, is a hallmark of Rheumatoid Arthritis (RA) and osteoporosis. Current therapies target inflammation but fail to prevent bone erosion, highlighti...
Direct antibacterial activity of allicin and restoration of carbapenem susceptibility by inhibiting New Delhi metallo-β-lactamase [0.03%]
大蒜素的直接抗菌活性及通过抑制新德里金属β内酰胺酶恢复碳青霉烯类药物敏感性
Xi Lv,Zhibin Ye,Xiaoming Wang et al.
Xi Lv et al.
Background: Carbapenem-resistant Enterobacterales (CRE), particularly strains producing New Delhi metallo-β-lactamase (NDM), represent a critical global health threat and underscore an urgent need for effective NDM inhib...
(-)-Epigallocatechin-3-gallate alleviates diarrhea in piglets by suppressing the NMU-NMUR1-ILC2 axis and modulating microbiota-associated energy metabolism [0.03%]
(-)-表没食子儿茶素没食子酸酯通过抑制NMU-NMUR1-ILC2轴并调节与微生物群相关的能量代谢来缓解仔猪腹泻
Ziwen Ma,Lujia Gao,Wanting Hou et al.
Ziwen Ma et al.
Background: Bacterial diarrhea is considered a global health crisis, accounting for approximately 20 % of deaths related to colorectal cancer. (-)-Epigallocatechin 3-gallate (EGCG), one of the most abundant plant-derived ...
Targeting USP4 to inhibit TGF-β signaling: the antifibrotic potential of isovitexin in renal interstitial fibrosis [0.03%]
靶向USP4抑制TGF-β信号：异黄酮异矢车菊素抗肾间质纤维化作用及机制研究
Jianhui Fan,Yuqi Liu,Shihong Zhan et al.
Jianhui Fan et al.
Background: Renal interstitial fibrosis (RIF), driven by persistent TGF-β signaling, is a hallmark of progressive kidney disease. Because deubiquitinases (DUBs) like USP4 stabilize TGF-β type I receptor (TβRI) to prolo...