Discovery of self-assembled nanoparticles from Rubia cordifolia L. before and after carbonization and mechanistic study on their targeted therapy for ulcerative colitis [0.03%]
自制纳米颗粒从碳化之前和之后的Rubia cordifolia L.及其针对溃疡性结肠炎的靶向治疗作用研究
Kangjie Li,Runxin Ren,Yiqiong Qi et al.
Kangjie Li et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options. The carbonization of Rubia cordifolia L. traditionally enhances its therapeutic effects, but the mechanism remain...
Farrerol alleviates obesity and hepatic steatosis by targeting translational regulation to coordinate cellular stress and lipid metabolism [0.03%]
弗拉罗通过靶向翻译调节来缓解肥胖和肝脂肪变性以协调细胞应激和脂质代谢
Shuting Huang,Jingyi Wang,Shouxiu Ma et al.
Shuting Huang et al.
Background: Dysregulation of lipid metabolism is a primary driver of obesity and related metabolic disease. Farrerol is a dihydroflavonoid derived from Rhododendron dauricum L., has known anti-inflammatory and antioxidant...
Entagenic acid targets ASCC2 to ameliorate allergic contact dermatitis via repressing NF‑κB transactivation and chemokine expression [0.03%]
entagenic酸通过抑制NF-κB转激活和细胞因子表达来改善过敏性接触性皮炎的新靶点ASCC2
Hui Xiong,Jiayue Yu,Ningbo Zhang et al.
Hui Xiong et al.
Background: Allergic contact dermatitis (ACD) is an inflammatory skin disease triggered by allergen exposure. Entagenic acid (EA) is the main triterpene aglycone isolated from Entada phaseoloides, which has been documente...
Rhein antagonizes glucocorticoid receptor signaling to activate SIRT1-dependent thermogenesis in brown adipose tissue and ameliorate obesity [0.03%]
Rhein通过拮抗糖皮质激素受体信号通路来激活棕色脂肪组织中的SIRT1依赖性产热并缓解肥胖症状
Ping Gu,Xuemei Zhao,Liufeng Mao et al.
Ping Gu et al.
Background: The obesity pandemic necessitates therapies that safely increase energy expenditure. Brown adipose tissue (BAT) is a key organ for energy dissipation. While the natural compound rhein has anti-obesity effects,...
Paclitaxel and triptolide impair MYC-driven cell cycle via suppressing chromatin reprogramming in ALDH1A3High pancreatic cancer [0.03%]
紫杉醇和三氧茋通过抑制ALDH1A3高表达胰腺癌中染色质重塑从而干扰MYC驱动型细胞周期进展
Shuang Nie,Yihang Jiang,Lingxi Meng et al.
Shuang Nie et al.
Background and purpose: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by transcriptional heterogeneity and chemoresistance. We previously identified an aggressive PDAC subtype defined...
Licochalcone B alleviates pulmonary vascular remodeling via inhibiting Furin/TGF-β1 in pulmonary hypertension [0.03%]
漆黄素B通过抑制肺动脉高压中的Furin/TGF-β1途径缓解肺血管重塑
Difei Gong,Ruiqi Liu,Xiaoyue Deng et al.
Difei Gong et al.
Background: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, and Furin, a proprotein convertase critical for TGF-β1 activation, has shown promise as a novel therapeutic target for PH. Howeve...
Dihydrotanshinone I inhibits PHGDH to suppress serine synthesis and remodel TME in NSCLC [0.03%]
丹参素I通过抑制PHGDH阻抑丝氨酸合成及重塑非小细胞肺癌肿瘤微环境
Cheng Qian,Hongkuan Han,Li Wan et al.
Cheng Qian et al.
Background: The strategy of limiting the availability of tumor cell phosphoglycerate dehydrogenase (PHGDH) has become a potential treatment for cancer. Modulation of the tumor-derived serine synthesis pathway to reprogram...
Cucurbitacin B targets PPAT to suppress de novo purine biosynthesis in esophageal squamous cell carcinoma [0.03%]
cucurbitacin B通过靶向ppat抑制从头嘌呤生物合成在食管鳞癌中的作用
Huajie Jia,Jing Guo,Hui Luo et al.
Huajie Jia et al.
Background: The de novo purine biosynthesis (DNPB) pathway is increasingly recognized as a key driver of tumor progression. Nevertheless, its precise role in regulating esophageal squamous cell carcinoma (ESCC) growth, ra...
Rehmannioside D prevents estrogen-deficiency induced osteoporosis by interacting with c-Jun to dismantle the AP-1 complex and suppress MAPK/NF-κB signaling [0.03%]
罗布苷D通过与c-Jun相互作用破坏AP-1复合物并抑制MAPK/NF-κB信号通路预防绝经后骨质疏松症
Yongli Wang,Jingtao Wu,Huabin Liu et al.
Yongli Wang et al.
Background: Postmenopausal osteoporosis (PMOP) necessitates novel therapeutics with defined targets. Rehmannioside D (RD), a bioactive compound from Rehmannia glutinosa, exhibits anti-inflammatory properties, yet its anti...
Huanglian Wendan ameliorates depression via gut-brain axis-related PPAR-α/allo pathways [0.03%]
黄连温胆汤通过PPAR-α/allo相关肠-脑轴通路改善抑郁症症状
Qingya Sun,Yijing Zhao,Jiayan Zhang et al.
Qingya Sun et al.
Background: Huanglian Wendan decoction (HLWD) is traditionally used to treat a syndrome characterized by symptoms such as insomnia, irritability, and digestive disturbances. Its historical application in addressing phlegm...