Baoping Jiang,Jiayi Si,Hongmei Luo et al.
Baoping Jiang et al.
Background: Traditional Chinese medicines (TCMs) have a long-standing history and diverse applications. However, their complex multi-component compositions and intricate mechanisms of action pose significant challenges fo...
Multi-omics and experimental validation reveal the mechanism of DanxiaTiaoban decoction in treating atherosclerosis [0.03%]
多组学及实验验证丹霞挑板方治疗动脉粥样硬化的作用机制
Yirong Ma,Miao Hu,Junyu Lai et al.
Yirong Ma et al.
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along...
20-Deoxyingenol attenuated doxorubicin-induced cardiotoxicity by promoting autolysosome degradation through the UCHL3-TFEB pathway [0.03%]
依木霉素K通过UCHL3-TFEB通路促进自噬溶酶体降解从而缓解阿霉素心肌毒性
De-Shu Chen,Yu-Xi Wang,Miao-Yuan Liang et al.
De-Shu Chen et al.
Background: Impaired autophagic flux is an essential contributor to doxorubicin (DOX)-induced cardiotoxicity (DIC). TFEB is recognized as a key regulator of DOX-induced autolysosome accumulation; however, the mechanisms b...
Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells [0.03%]
oleandrin介导的MELK抑制诱导人类非小细胞肺癌细胞凋亡、自噬和铁死亡
Ejlal A Omer,Min Zhou,Wynand P Roos et al.
Ejlal A Omer et al.
Background: Non-small-cell lung cancer NSCLC is the major diagnosed type of lung cancers in the USA and Europe. It is generally related to poor prognosis and low rates of survival. Oleandrin is a cardiac glycoside occurri...
Polyphenol from walnut septum alleviates DSS-induced colonic injury by regulating the PI3K-AKT pathway signaling and gut microbiota in mice [0.03%]
walnuts多酚通过调节PI3K-AKT信号通路和肠道微生物群来缓解小鼠DSS诱导的结肠损伤
Zishan Hong,Jinlian Chen,Chongying Shi et al.
Zishan Hong et al.
Background: Walnut septum, a Juglans regia L. by-product with culinary-medicinal value, is a rich source of bioactive polyphenols. The chemical complexity and anti-colitis activities of these polyphenols remain uncharacte...
Corrigendum to "Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration" [Phytomedicine 145 (2025) 157039] [0.03%]
黄芪桂枝五物汤通过调整髓鞘再生治疗奥沙利铂诱发的外周神经病变的勘误说明[Phytomedicine 145(2025)157039]
Xueying Yang,Huaying Zhu,Zhiyu Li et al.
Xueying Yang et al.
Huangkui capsules for diabetic nephropathy: Comprehensive review of efficacy and molecular mechanisms [0.03%]
黄葵胶囊治疗糖尿病肾病的疗效及分子机制综合述评
Xueyin Chen,Yan Yu,Cuixia Xiao et al.
Xueyin Chen et al.
Background: The management of kidney diseases urgently needs additional therapeutic options. Encouraging evidence suggests the efficacy of Huangkui capsules (HKCs), a plant-derived traditional medicine, in treating variou...
A xanthone O-glucoside isolated from Iris setosa Pall. ex Link exhibits promising anti-amoebic activity against the brain-eating amoeba Naegleria fowleri [0.03%]
帕尔塞克斯林 iris setosa 马兜铃黄酮O-葡萄糖苷对食脑变形虫福氏耐格里阿米巴具有潜在的抗阿米巴活性
Hương Giang Lê,Buyng Su Hwang,Ji-Su Choi et al.
Hương Giang Lê et al.
Background: Primary amoebic meningoencephalitis (PAM), caused by Naegleria fowleri, poses a significant challenge in humans owing to its high mortality rate, exceeding 97 %. Current therapeutics have been unable to delive...
Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models [0.03%]
核桃多肽和茶氨酸在人脑类器官和小鼠应激模型中的协同减压和提高认知作用
Qixing Zhong,Qinxi Li,Xiuzhen Jia et al.
Qixing Zhong et al.
Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, ...
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence [0.03%]
石南素A抑制胃癌：机制见解与综合证据支持
Yonghao Fan,Yan Chen,Wenyan Lu et al.
Yonghao Fan et al.
Background: Traditional Chinese medicine (TCM) has shown anti-tumor potential, but its molecular mechanisms remain poorly understood. This integrated bioinformatics, network pharmacology, and experimental study investigat...