Wedelolactone targets SORBS1 to regulate glycolipid metabolism and suppress inflammation, thereby alleviating diet-induced MASH via multiple pathways [0.03%]
wedelolactone通过多重途径靶向SORBS1调节糖脂代谢并抑制炎症，从而缓解饮食诱导的MASH
Wei Zhang,Ya Bai,Dong Xu et al.
Wei Zhang et al.
Background: The pathogenic mechanisms underlying metabolic dysfunction-associated steatohepatitis (MASH) are highly complex and multifactorial, and there are limited pharmacological therapies proven effective for clinical...
Peitu Qingxin formula ameliorates atopic dermatitis by targeting the multi-omics-informed miR-30a/GAPR-1 axis in sphingolipid metabolism [0.03%]
皮图清心方通过靶向鞘脂代谢的多组学引导的miR-30a/GAPR-1轴改善特应性皮炎
Wenfeng Wu,Zexin Zhang,Boqian Zhou et al.
Wenfeng Wu et al.
Background: Dysregulated sphingolipid metabolism plays a key role in atopic dermatitis (AD), yet therapeutic options targeting this pathway remain limited. The traditional formula Peitu Qingxin (PTQX) shows clinical effic...
Integrating UHPLC-HRMS with SSA-BP neural network identifies optimal components of Astragali Radix‑Salviae Miltiorrhizae combination for mitigating cerebral ischemia-reperfusion injury via mitophagy and ferroptosis pathways [0.03%]
基于UHPLC-HRMS的SSA-BP神经网络建立结合优化黄芪汤丹参配伍药效物质基础及其减缓缺血再灌注损伤的作用机制研究
Chao Guo,Dong Xu,Zhongying Ma et al.
Chao Guo et al.
Background: Astragali Radix (Huangqi) and Salvia miltiorrhiza (Danshen) represent a frequently paired herbal combination in traditional Chinese medicine for tonifying Qi and promoting blood circulation. Previous pharmacol...
Tanshinone IIA attenuates myocardial ischemia by targeting FGFR1 residue Gln284 for allosteric modulation and subsequent autophagy inhibition [0.03%]
丹参酮 ⅡA 抑制心肌缺血的机制研究：别构调节FGFR1残基Gln284以抑制自噬作用
Chenhui Zhong,Qingyun Lin,Yan Chen et al.
Chenhui Zhong et al.
Background: Myocardial ischemia (MI) causes diverse pathological injuries, and pharmacological intervention remains a key therapeutic approach. Tanshinone IIA (Tan IIA), a principal active compound derived from the tradit...
Pseudoginsenoside F11 alleviates atherosclerosis by regulating SIRT3-mediated deacetylation of SOD2 [0.03%]
伪绞股蓝皂苷F11通过调节SIRT3介导的SOD2去乙酰化来缓解动脉粥样硬化
Wenjie Bi,Rong Dong,Jin Ren et al.
Wenjie Bi et al.
Background: Endothelial protection has emerged as a promising therapeutic strategy for cardiovascular diseases such as atherosclerosis (AS). However, no endothelial-targeted therapeutic drugs have yet been used in clinica...
Refined Changqin NO.1 regulates gut microbiota and their metabolites to mediate PANoptosis and alleviate traumatic brain injury [0.03%]
精制常琴一号调节肠道微生物群及其代谢物介导PANoptosis以缓解创伤性脑损伤
Yeli Xie,Chunhu Zhang,Chunyuan Guo et al.
Yeli Xie et al.
Background: Refined Changqin NO.1 (R-Cq1) has shown favorable therapeutic effects in traumatic brain injury (TBI), which triggers neuronal PANoptosis and involves dysregulation of gut microbiota and metabolites. ...
Hedyotis diffusa Willd-Scutellaria barbata herbal pair suppresses triple-negative breast cancer metastasis by targeting the tumor-associated macrophage-driven OPN-CD44 signaling axis [0.03%]
一枝黄花与夏枯草抑制肿瘤相关巨噬细胞驱动的OPN-CD44信号轴以阻遏三阴性乳腺癌转移
Yubao Zhang,Yiran Liu,Fubin Feng et al.
Yubao Zhang et al.
Background: Triple-negative breast cancer (TNBC) is characterized by a high propensity for metastatic relapse and a robust infiltration of tumor-associated macrophages (TAMs), which orchestrate a pro-metastatic microenvir...
EGCG improves follicular development of diabetic mice by the hypothalamic-pituitary-ovarian axis [0.03%]
EGCG通过下丘脑-垂体-卵巢轴改善糖尿病小鼠卵泡发育
Hua-Chao Gao,Jing Lin,Li-Jun Li et al.
Hua-Chao Gao et al.
Background and purpose: Impaired oocyte quality of diabetic mice can be improved by epigallocatechin gallate (EGCG) in vitro. However, the underlying mechanism is unknown. Here, we examined whether EGCG improves follicula...
Huangjin Shuangshen Jiawei decoction alleviated coronary heart disease comorbid with depression partly through gut microbiota-mediated regulation of the SRSF1-p53-ASPP1 signaling axis [0.03%]
黄金双神剂戊颗粒通过肠道菌群介导的SRSF1-p53-ASPP1信号轴调节部分缓解冠心病合并抑郁症
Ruiting Jia,Yuman Wang,Jieyi Wang et al.
Ruiting Jia et al.
Background: Coronary heart disease comorbid with depression (CHDD) was associated with poor clinical outcomes and was increasingly linked to gut microbiota dysregulation. Huangjin Shuangshen Jiawei decoction (HJSSJW) show...
Tanshinone I as a novel ferritinophagy inducer triggers ferroptosis to suppress gastric cancer growth [0.03%]
丹参酮I通过诱导铁死亡抑制胃癌生长
Baoyu Wei,Hailong Shen,Chengtao Sun et al.
Baoyu Wei et al.
Background: Gastric cancer (GC) remains a major global health challenge, underscoring the urgent need for effective therapeutic strategies. Ferritinophagy-driven ferroptosis has recently emerged as a promising anticancer ...