Targeting USP4 to inhibit TGF-β signaling: the antifibrotic potential of isovitexin in renal interstitial fibrosis
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Background: Renal interstitial fibrosis (RIF), driven by persistent TGF-β signaling, is a hallmark of progressive kidney disease. Because deubiquitinases (DUBs) like USP4 stabilize TGF-β type I receptor (TβRI) to prolong signa... ...
