Murtala Bindawa Isah,Nasir Tajuddeen,Anas Yusuf et al.
Murtala Bindawa Isah et al.
Background: Diabetes mellitus (DM) is a chronic metabolic disease with a high global prevalence. Lignans, a class of plant natural compounds found in commonly consumed foods, are well-tolerated by humans and have demonstr...
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity [0.03%]
丙戊酸通过介导组蛋白乙酰化促进Drd2转录激活以抑制mTOR-Pttg1信号轴并发挥抗催乳素垂体神经内分泌肿瘤作用
Qiu Du,Zhiyong Chen,Zize Feng et al.
Qiu Du et al.
Background: Valproic acid (VPA), a short branched-chain fatty acid derived from valeric acid naturally produced by Valeriana officinalis L., is widely used in clinical settings for the treatment of epilepsy. Furthermore, ...
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury [0.03%]
Schisandrin B通过激活AKT1和线粒体靶向来调节线粒体动力学，以改善肾缺血再灌注损伤
Changhong Xu,HuaBin Wang,Hailong Wang et al.
Changhong Xu et al.
Background: Renal ischemia-reperfusion injury (RIRI) is a significant cause of acute kidney injury(AKI) and delayed graft function(DGF), impacting post-transplant outcomes. Mitochondrial dynamics, in particular fission an...
Ethyl caffeate alleviates inflammatory response and promotes recovery in septic-acute lung injury via the TNF-α/NF-κB/MMP9 Axis [0.03%]
乙基咖啡酸通过TNF-α/NF-κB/MMP9轴减轻炎性反应并促进脓毒症急性肺损伤修复
Yuanlan Huang,Gang Li,Dan Li et al.
Yuanlan Huang et al.
Background: Septic acute lung injury (Septic-ALI, SA) is a severe complication of sepsis with limited clinical treatment options. Ethyl Caffeate (EC) is a phenolic compound isolated from Ilex latifolia Thunb (I. latifolia...
The microglial state transition as a novel mechanism by which fresh Baihe Dihuang decoction prevents depression by regulating SIRT1/HMGB1 signaling [0.03%]
新鲜柏地养心汤防治抑郁的机理研究——微胶质细胞表型转换介导的SIRT1/HMGB1信号通路调节作用探讨
Li-Hua Cao,Zhen-Zhen Wang,Hui Zhao et al.
Li-Hua Cao et al.
Background: Fresh Baihe Dihuang decoction (FBD) is a classic Traditional Chinese Medicine (TCM) formula used to treat depression. However, its underlying molecular mechanisms in treating depression still need further expl...
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway [0.03%]
救心方通过AMPK/SIRT1/PGC-1α信号通路改善心肌梗死小鼠心肌代谢的保护作用
Xinyi Fan,Xiaoqi Wei,Wendi Wang et al.
Xinyi Fan et al.
Background: Cardiac dysfunction continues to represent a major global health burden, significantly impacting both disease prevalence and survival rates across populations. Mitochondrial dysfunction is a severe pathologica...
Exploration of mechanism of Bufalin and Bufalin derivatives in hepatocellular carcinoma [0.03%]
研究蟾毒灵及其衍生物治疗肝癌的机制
Xinchen Gao,Tianrun Bian,Xinyu Wei et al.
Xinchen Gao et al.
Background: Bufalin, a promising candidate for the treatment of hepatocellular carcinoma (HCC), has garnered interest from researchers in exploring its pharmacological mechanisms. The traditional single-target research me...
Soufeng Sanjie formula alleviates the progression of lupus and joint injury by regulating the ALKBH5-FoxO1-PFKFB3 axis in M-MDSCs [0.03%]
疏风三剂通过调节M-MDSCs中的ALKBH5-FoxO1-PFKFB3轴来缓解狼疮的进展和关节损伤
Liping Tan,Xiuzhu Wang,Shuangan Wang et al.
Liping Tan et al.
Background: Systemic lupus erythematosus (SLE) cases present with impaired immune function and injured organs, with joint injury being one of the most common complications. Soufeng Sanjie formula (SF) is a traditional Chi...
Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy [0.03%]
阿皮根素可增强Nrf2介导的分子伴侣介导的自噬并缓解α-突触核蛋白病理：帕金森病治疗的潜在意义
Yi-Bin Huang,Lu-Lu Tian,Zi-Wen Zhu et al.
Yi-Bin Huang et al.
Background: The aggregation of α-synuclein (SNCA) in dopaminergic neurons of the substantia nigra is a key factor in the pathogenesis of Parkinson's disease (PD). Despite years of drug discovery efforts targeting SNCA ag...
Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-κB p105 Ubiquitination [0.03%]
吲哚-3-甲醇通过抑制NF-κB p105泛素化抑制PD-L1介导的肝癌免疫逃逸
Yongkang Wu,Qing Tao,Jing Xie et al.
Yongkang Wu et al.
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and immunotherapy has demonstrated significant therapeutic benefit in HCC. Indole-3-carbinol (I3C), a naturally occurring in...