The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis [0.03%]
黄花夹竹桃素通过ATP1A1-Src-YAP / TAZ-TFRC轴增强胃癌细胞的铁死亡敏感性
Angting Ke,Weiguang Yang,Wanchuan Zhang et al.
Angting Ke et al.
Background: Targeting ferroptosis vulnerabilities in tumors has become an increasingly promising therapeutic strategy. While the regulatory effects of natural products on ferroptosis are progressively being elucidated, th...
Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses [0.03%]
补骨脂内酯通过共价修饰巨噬细胞中高迁移率族蛋白箱1的半胱氨酸106位点抑制炎症反应从而缓解急性肺损伤
Yixu Wang,Jin Zhang,Sihan Xu et al.
Yixu Wang et al.
Background: Acute lung injury (ALI) is a critical pathophysiological response in various respiratory diseases characterized by alveolar damage and excessive inflammation. It can progress to acute respiratory distress synd...
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation [0.03%]
柯因通过IP3R1-GRP75-VDAC1复合物介导线粒体ROS的生成以改善 CIT 所致肠道炎症反应
Yuanyuan Li,Xiaofang Liu,Qike Zhang et al.
Yuanyuan Li et al.
Background: Citrinin (CTN) is a mycotoxin that is difficult to eliminate and easy to ingest. Chronic exposure to CTN can lead to inflammatory bowel disease (IBD). The herb Koumine has strong anti-inflammatory activity and...
Nuciferine activates intestinal TAS2R46 to attenuate metabolic disorders and hyperlipidemia via hepatic VLDL regulation [0.03%]
莲心碱通过肝脏VLDL调节激活肠道TAS2R46来改善代谢异常和高脂血症
Chen Ding,Jian Ruan,Jingxian Huang et al.
Chen Ding et al.
Background: Dysregulated blood lipid metabolism, a primary driver of hyperlipidemia, is closely associated with excessive very low-density lipoprotein (VLDL) synthesis and secretion. Nuciferine, a bioactive compound isola...
Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy [0.03%]
一种天然的STAT3抑制剂-前瓦昆醇A可抑制黑色素瘤细胞增殖并诱导自噬效应
Xiao-Li Jiang,Bin Liu,Jun-Kui Li et al.
Xiao-Li Jiang et al.
Background: Melanoma is a deadly malignant skin cancer with common risk factors including prolonged ultraviolet exposure. Understanding the mechanisms of signal transducer and activator of transcription (STAT3) signaling ...
Tea residue protein-derived oligopeptides attenuate DSS-induced acute colitis complicated with hepatic injury in C57BL/6J mice by regulating the gut-microbiome-liver axis [0.03%]
茶渣蛋白寡肽通过调节肠-微生态-肝轴减轻C57BL/6J小鼠DSS诱导的急性结肠炎伴肝脏损伤
Fengxue Qi,Ziyi Shen,Simeng Zhou et al.
Fengxue Qi et al.
Background: Impairment of the intestinal mucosal barrier is a prevalent feature of acute colitis, and untreated acute colitis can lead to extra-intestinal manifestations, including hepatic injury. Previous research has de...
Diosmetin attenuates the ubiquitination of epidermal hypoxia-inducible factor 1 alpha by diminishing the formation of RhoBTB3/PHD2 complex in ultraviolet radiation-induced sunburn in mice [0.03%]
染料木素通过减少RhoBTB3/PHD2复合体的形成来抑制紫外线诱导的日晒红斑中表皮HIF-1α的泛素化作用
Xiaobao Gong,Shun Yang,Zhongxue Yuan et al.
Xiaobao Gong et al.
Background: The accumulation of excessive reactive oxygen species (ROS) in keratinocytes is a pivotal mechanism underlying ultraviolet radiation (UVR)-induced skin damage and carcinogenesis. Disruption of redox homeostasi...
The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis [0.03%]
菊花花蕾提取物通过抑制PANoptosis和恢复肌肉稳态来缓解卒中后肌少症
Hu Qi,Xiongwei Zhang,Zeyang Zhang et al.
Hu Qi et al.
Background: Sarcopenia and muscle weakness are prevalent complications of ischemic stroke (IS), with limited pharmacological options. This study identifies high-dose extracts of Chrysanthemum Flos (ECF) as a potential the...
Nephroprotective effects of Amomum kravanh essential oil by inhibition of ferroptosis regulated by Nrf2/HO-1 signaling pathway [0.03%]
通过抑制由Nrf2/HO-1信号通路调节的铁死亡的肾保护作用-Amomum kravanh精油的作用
Xiaoling Cheng,Wenli Hao,Silin Yu et al.
Xiaoling Cheng et al.
Background: Amomum kravanh Pierre ex Gagnep. (BDK) is a Zingiberaceae plant traditionally widely used as a sweet fragrance, and commonly also utilized in minority medicine for various kidney diseases, especially chronic k...
Glycyrrhetinic acid ameliorates gastric mucosal injury by modulating gut microbiota and its metabolites via Thbs1/PI3K-Akt/p53 pathway [0.03%]
甘草酸通过Thbs1/PI3K-Akt/p53信号途径调节肠道微生态改善胃黏膜损伤
Zheng-Meng Jiang,Zhi-Yue Fang,Xing Yang et al.
Zheng-Meng Jiang et al.
Background: Dysbiosis of the gut microbiota is pivotal in the development of gastric mucosa injury (GMI). Glycyrrhetinic acid (GA) is a bioactive triterpenoid compound abundantly present in licorice roots. Although GA's p...