Diosmetin attenuates the ubiquitination of epidermal hypoxia-inducible factor 1 alpha by diminishing the formation of RhoBTB3/PHD2 complex in ultraviolet radiation-induced sunburn in mice
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Background: The accumulation of excessive reactive oxygen species (ROS) in keratinocytes is a pivotal mechanism underlying ultraviolet radiation (UVR)-induced skin damage and carcinogenesis. Disruption of redox homeostasis exacer... ...