Fruit of Physalis angulata L. and anti-inflammatory potential: An in silico, in vitro, and in vivo study focusing on PFKFB3 [0.03%]
用Physalis angulata L.的果实研究其抗炎潜力：以PFKFB3为重点的体内和体外综合研究及分子对接研究
Jing Liu,Yifei Le,Jingwei Wang et al.
Jing Liu et al.
Background: Sepsis-associated lung injury (SALI) is a disease characterised by inflammation. The fruit of Physalis angulata L. has been employed as a premium, novel, nutritious, healthcare "herbal fruit", which can be pro...
Ponicidin promotes ferroptosis to enhance treatment sensitivity in Lenvatinib-resistant hepatocellular carcinoma cells through regulation of KEAP1/NRF2 [0.03%]
ponicidin通过调控KEAP1/NRF2促进肝癌细胞铁死亡从而增强对Lenvatinib的敏感性
Lisha Zhang,Hao Wang,Beibei Liang et al.
Lisha Zhang et al.
Objective: This study explores the therapeutic potential of Ponicidin on Lenvatinib-resistant hepatocellular carcinoma (HCC), elucidates its mechanism in reversing Lenvatinib resistance, and provides experimental evidence...
Myricetin prevents roast chicken breast-induced liver damage by regulating NF-κB/MAPK signaling pathway-mediated liver inflammation and intestine barrier damage in mice [0.03%]
芦丁通过调节NF-κB / MAPK信号通路介导的肝脏炎症和肠道屏障损伤预防烤鸡胸引起的肝损伤
Hongting Deng,Yanan Zhao,YuanYuan Hu et al.
Hongting Deng et al.
Background: Roast chicken breast contains a certain number of heterocyclic amines (HCAs), which induces damage of liver, colon, and other organs. Myricetin (MY) is a polyhydroxyl flavonol compound known for its anti-infla...
Regulation of inflammation by Chaihu-Shugan-San: Targeting the IL-17/ NF-κB pathway to combat breast cancer-related depression [0.03%]
柴胡舒肝散通过调节炎症抗乳腺癌相关抑郁的机制研究：靶向IL-17/NF-κB信号通路
Zhongyuan Qu,Huimin Li,Fajing Qiang et al.
Zhongyuan Qu et al.
Background: Breast cancer-related depression (BCRD) is one of the severest comorbidities, affecting the quality of life and the treatment efficacy in BC patients. Chaihu-Shugan-San (CSS), a traditional Chinese medicine pr...
Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization [0.03%]
五味子醇B通过抑制神经元铁死亡和随后的小胶质细胞M1极化改善阿尔茨海默病
Tao Ding,Meiying Song,Yongshi Wu et al.
Tao Ding et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal damage, with poor prognosis and limited therapeutic options. Inhibition of neuronal ferroptosis has shown promise as a potenti...
Morusin ameliorates tubulointerstitial damage in diabetic mice through SIRT1/HIF-1α/IL-16 signaling pathway [0.03%]
摩酚素通过SIRT1/HIF-1α/IL-16信号途径改善糖尿病小鼠的肾小管间质损害
PeiYuan Kang,Lin Xiao,YiXian Liu et al.
PeiYuan Kang et al.
Background and purpose: Hypoxia is generally considered the major cause of renal tubular injury. The interaction between sirtuin 1 (SIRT1) and hypoxia inducible factor 1 subunit alpha (HIF-1α) is a key mediator of hypoxi...
Plantamajoside alleviates DSS-induced ulcerative colitis by modulating gut microbiota, upregulating CBS, and inhibiting NF-κB [0.03%]
植物胺皂甙通过调节肠道菌群、上调CBS和抑制NF-κB缓解DSS诱导的溃疡性结肠炎
Yongheng Jia,Xianjun Liu,Xinyi Gao et al.
Yongheng Jia et al.
Background: Plantamajoside (PMS) is a natural bioactive compound derived from medicinal, food homologous plants of the genus Plantago. Purpose and methods...
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis [0.03%]
Ginsenoside Rg3通过靶向和调节微生物-肠道-脑轴缓解氯吡rifos引起的脑损伤
Silu Liu,Yang Yang,Ying Zong et al.
Silu Liu et al.
Introduction: The utilization of organophosphorus pesticides (OPs) has been demonstrated to exert a substantial positive influence on crop yield enhancement. However, due to the multitude of exposure routes and the persis...
Deciphering the molecular mechanisms of QLQX capsules in heart failure: A multi-omics perspective [0.03%]
从多组学角度解读QLQX胶囊治疗心力衰竭的分子机制
Jiameng Hao,Mingye Wang,Qiulan Wu et al.
Jiameng Hao et al.
Purpose: This study investigates the therapeutic mechanisms of Qiliqiangxin (QLQX) capsules in treating Heart Failure with Preserved Ejection Fraction (HFpEF). The study aims to understand how QLQX impacts cardiac functio...
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe [0.03%]
脱氧 podophyllotoxin 通过诱导坏死性凋亡和有丝分裂灾难来抑制恶性胸膜间皮瘤的生长
Cheng Zhong,Shenqi Wang,Jingyuan Zhang et al.
Cheng Zhong et al.
Background: Malignant pleural mesothelioma (MPM) is an extremely aggressive cancer with a poor prognosis and limited effective treatment options. However, recent studies have shown that targeting microtubule regulation is...