Explore dual anti-inflammatory and cell protective mechanisms the mechanism of Jianwei Yuyang tablet in the treatment of alcohol-induced gastric ulcers via bioinformatics and experimental validation [0.03%]
基于生物信息学和实验验证的健胃愈疡片治疗酒精性胃溃疡双重抗炎与细胞保护机制探讨
Bilal Ahmed,Chenchen Jiang,Kexuan Huang et al.
Bilal Ahmed et al.
Background: Jianwei Yuyang Tablet (JWYY), a Chinese herbal formulation, has been approved for the treatment of various gastric diseases in clinic and has demonstrated significant therapeutic effects in patients with multi...
Efficacy and safety of Shuxuening injection in patients with unstable angina: a multicenter, randomized, placebo-controlled trial [0.03%]
舒血宁注射液治疗不稳定性心绞痛有效性与安全性的多中心随机安慰剂对照试验
Lintong Yu,Shiyi Tao,Qian Lin et al.
Lintong Yu et al.
Objective: To determine the efficacy and safety of adjunct Shuxuening Injection (SXN) on conventional therapy in patients with unstable angina (UA) which provides a complementary choice and its evidence for clinical medic...
Suppressing neuroinflammation by Shenfu injection against ischemic stroke in mice via inhibiting RAGE-PI3K-Akt pathway [0.03%]
通过抑制RAGE-PI3K-Akt途径遏制神经炎症作用的参附注射液治疗小鼠缺血性中风
Shichun Li,Yongqiang Wang,Xiangyu Sun et al.
Shichun Li et al.
Background: Ischemic stroke presents a major clinical challenge, often resulting in significant mortality and long-term disability. Shenfu injection (SF), a traditional Chinese herbal formulation, has demonstrated protect...
Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis [0.03%]
modification的liposome递送FTY720促进胶质母细胞瘤靶向及抗肿瘤活性通过铁死亡
Huizhe Xu,Zhisheng Wu,Jiamei Tang et al.
Huizhe Xu et al.
Background: Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment. Recent studies have repo...
Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB α5β1, especially in patients with high expression of ACPA [0.03%]
白藜芦醇通过SIRT1和ITGBα5β1减少类风湿关节炎中NLRP3炎症小体的活化，特别是在抗瓜氨酸蛋白抗体高表达患者中
Li Cai,Kai Zhang,Jian Gao et al.
Li Cai et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease with synovitis as the main pathological change. Previous research has demonstrated that the NLRP3 inflammasome is hyperactivated in RA patients, with i...
Diosgenin promoted OPCs differentiation via blocking GLUR2/GAPDH interaction in a pilocarpine rat model of epilepsy [0.03%]
薯蓣皂苷通过阻断GLUR2/GAPDH相互作用促进OPCs分化在毛果芸香碱癫痫模型中发挥作用
Zixuan Gao,Lei Wang,Qingwei Lai et al.
Zixuan Gao et al.
Background: Central nervous system (CNS) demyelination is associated with the occurrence of epileptic seizure, highlighting the imperative need for myelin repair strategy. Inefficient differentiation of naïve oligodendro...
Therapeutic potential of inosine in acute lung injury: mechanistic insights into TLR4 suppression and macrophage polarization [0.03%]
次黄嘌呤在急性肺损伤中的治疗潜力：TLR4抑制和巨噬细胞极化的机制启示
Tong Liu,Caihua Tian,Huahua Li et al.
Tong Liu et al.
Background: As severe inflammatory condition, acute lung injury (ALI) can progress to acute respiratory distress syndrome (ARDS), for which no effective therapy has been reported. Inosine, a bioactive nucleoside derived f...
Astragaloside IV inhibits the growth of obesity-associated triple-negative breast cancer by activating FOXA1 transcription factor to regulate GAL3ST1-GalCer signaling and remodel sphingolipid metabolism [0.03%]
绞股蓝皂苷IV通过激活FOXA1转录因子调节GAL3ST1-GalCer信号并重塑鞘脂代谢来抑制肥胖相关三阴性乳腺癌的生长
Yaqin Yang,Jun Lu,Yuru Zhu et al.
Yaqin Yang et al.
Background: Obesity is linked to a heightened risk of developing triple-negative breast cancer (TNBC). Obesity-associated triple-negative breast cancer (OA-TNBC) presents limited therapeutic options and is characterized b...
Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats [0.03%]
多组学分析揭示了海 buckthorn 和奶蓟固体饮料的降脂功效：高血脂大鼠模型研究
Yuwei Bai,Jianglong Li,Xueqian Wu et al.
Yuwei Bai et al.
Background: Hyperlipidemia is a common metabolic disorder and a risk factor for cardiovascular disease. The traditional medicine herb, Hippophae rhamnoides L., known as sea buckthorn, has anti-obesity and lipid-lowering e...
Neophytadiene: Biological activities and drug development prospects [0.03%]
.neophytadiene：生物活性及药物开发前景
Srinath Rajeswaran,Durairaj Karthick Rajan
Srinath Rajeswaran
Background: Neophytadiene (NPT) [C20H38] or 7, 11, 15-Trimethyl-3-methylenehexadec-1-ene is a diterpene found in the important oil of various plants, including neem (Azadirachta indica). It possesses inhibitory properties...