Molecular mechanisms and therapeutic potential of quercetin in ovarian functions [0.03%]
檞皮素的分子机制及其在卵巢功能中的治疗潜力
Xiaoyu Zhang,Xuyang Cui,Fengjun Ma et al.
Xiaoyu Zhang et al.
Background: Quercetin is a naturally occurring flavonoid abundant in various fruits and vegetables, known for its broad pharmacological properties, including antioxidant, anti-inflammatory, anti-apoptotic, and anti-fibrot...
Lian Qiao Wen Dan Decoction attenuates gastric carcinogenesis by alleviating oxidative phosphorylation dysfunction [0.03%]
连翘温胆汤通过改善氧化磷酸化功能障碍抑制胃癌发生发展
Xiuping Chi,Yanru Song,Sisi Wei et al.
Xiuping Chi et al.
Background: Wen Dan Decoction (WDD) is primarily utilized as an "expectorant" in clinical practice. The combination of WDD and Lian Qiao (LQWDD) exhibits synergistic effects on phlegm resolution, qi regulation, and detoxi...
Tanshinone IIA improved psychological stress-induced embryo implantation disorders by inhibiting GC/GR signaling and promoting angiogenesis [0.03%]
丹参酮ⅡA通过抑制GC/GR信号传导和促进血管生成来改善心理应激诱导的胚胎着床障碍
Fangfang Li,Shiyu Zhao,Qunying Fang et al.
Fangfang Li et al.
Background: The exact mechanism by which psychological stress leads to embryo implantation disorders remains unclear. Studies have shown that psychological stress is associated with elevated levels of glucocorticoids (GC)...
Brusatol induced ferroptosis in osteosarcoma cells by modulating the Keap1/Nrf2/SLC7A11 signaling pathway [0.03%]
溴化饱和素通过调节Keap1/Nrf2/SLC7A11信号通路诱导骨肉瘤细胞铁死亡
Long Zhang,Doudou Luo,Haijiang Ren et al.
Long Zhang et al.
Osteosarcoma (OS) is a rare primary malignant bone tumor. Despite ongoing research efforts, improvements in the five-year survival rate of OS patients remain limited. Therefore, there is an urgent need to identify novel therapeutic agents t...
The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway [0.03%]
Polygonatum sibiricum的正丁醇萃取物通过p53途径改善脾脏衰老
Jingtong Chao,Yu Wang,Qidi Huang et al.
Jingtong Chao et al.
Background: Aging affects the function of multiple organs, including the spleen, which undergoes age-related structural changes and functional decline. Polygonatum sibiricum, a traditional anti-aging herbal medicine, cont...
Hydroxysafflor yellow A promotes the proliferation and differentiation of endogenous neural stem cells with neural regenerative effects in ischemic stroke [0.03%]
冠心黄A通过促进缺血性卒中后内源性神经干细胞增殖分化发挥神经再生效应
Zhaojun Wang,Zhongqing Liu,Ying Hao et al.
Zhaojun Wang et al.
Background: Ischemic stroke induced irreversible damage or loss of neurons, severely causing high death rates. Natural medicine has rapidly risen for stroke therapy. Given the activation of neural cells, it is crucial to ...
Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system [0.03%]
伞形花内酯通过调节线粒体质量和泛素-蛋白酶体系改善糖尿病肌少症
Dong Yeon Kim,Young-Hee Kang,Min-Kyung Kang
Dong Yeon Kim
Background: Sarcopenia, characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, is traditionally associated with aging. However, chronic conditions such as type 2 diabetes mellit...
Dihydromyricetin alleviates lipid peroxidation-induced Pyroptosis by inhibiting xCT ubiquitination and degradation in experimental COPD model [0.03%]
二氢杨梅素通过抑制xCT泛素化降解缓解实验性慢性阻塞性肺疾病模型中的脂质过氧化诱导的焦亡现象
Tianhua Hou,Ying Tang,Lu Wang et al.
Tianhua Hou et al.
Background: Dihydromyricetin (DHM), a flavonoid primarily sourced from Ampelopsis grossedentata, exhibits anti-inflammatory and antioxidant biological activities. However, the therapeutic effects and the precise underlyin...
Discovery of a novel MARK4 antagonist from safflower to improve ischemic stroke by inhibiting microglial NLRP3 inflammasome activation [0.03%]
通过抑制微胶质细胞NLRP3炎性小体活化改善缺血性卒中的发现一种新的MARK4拮抗剂--番红花化合物
Ze-Jie Zeng,Xiaobing Lin,Pei-Qing Wang et al.
Ze-Jie Zeng et al.
Background: Neuroinflammation has been proven to be a significant factor linked to stroke, with NLRP3 inflammasome activation being a common neuroinflammatory manifestation. Microtubule affinity regulated kinase 4 (MARK4)...
Nucleolin inhibits α-synuclein to attenuate aconitine's neurotoxicity [0.03%]
核仁蛋白通过抑制α-突触核蛋白毒性减轻附子中毒的神经毒性损伤
Guangxin Liu,Wenqiang Zuo,Zhen Zhang et al.
Guangxin Liu et al.
Background: Aconitine (AC), a toxic alkaloid derived from Aconitum species, presents a significant risk of neurotoxicity with global poisoning reports. Pu...