COL6A3 drives tumor progression and predicts prognosis in cervical squamous cell carcinoma [0.03%]
COL6A3驱动宫颈鳞状细胞癌肿瘤进展并预示预后
Qingge Jia,Jin Liu,Tianqi Xu et al.
Qingge Jia et al.
Background: Cervical squamous cell carcinoma (CESC) is the most prevalent histological subtype of cervical cancer, and patients with advanced or metastatic disease still face a dismal prognosis. Collagen type Ⅵ alpha 3 (...
A novel oxygen-releasing bilayer delivery system for cell survival and peripheral nerve regeneration [0.03%]
一种新颖的氧释放双层递送系统促进细胞存活及周围神经再生
Jiaqi Wang,Qing Zhang,Lingli Guo et al.
Jiaqi Wang et al.
Peripheral nerve injuries with long-gap defects pose a major regenerative challenge due to hypoxic microenvironments that impair cell survival and nerve repair. Here, we engineered a bilayer microsphere delivery system that encapsulates Per...
Autophagy modulation in ulcerative colitis with traditional Chinese medicine: A review [0.03%]
中医药溃疡性结肠炎自噬调节研究进展
Benkai Xing,Xiaohui Ji,Zhenhua Guo et al.
Benkai Xing et al.
Background: Ulcerative colitis (UC) is a diffuse inflammatory disease that affects the rectum and colon. Management predominantly relies on pharmacotherapy, but challenges related to the side effects, hormone dependence, ...
Ras signalling in infectious disease pathology: Mechanisms, tissue damage, and clinical implications [0.03%]
拉波特病发病机制：机制、组织损伤和临床意义
Atahar Husein,Azfar Jamal,Rahat Ali et al.
Atahar Husein et al.
Ras signalling is an important regulator of cell proliferation, survival, differentiation, and immune responses. Although Ras pathways have been extensively studied in cancer biology, increasing evidence suggests that many pathogens also ma...
CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction [0.03%]
涉及AML中的inv（16）的CBFβ-SMMHC：融合生物学，RUNX1失调以及针对一种白血病相关蛋白质-蛋白质相互作用的治疗靶向性研究
Emadeldin M Kamel,Sally Mostafa Khadrawy,Mohamed A M Ali et al.
Emadeldin M Kamel et al.
Acute myeloid leukemia with inv(16) is defined by the CBFB::MYH11 fusion, which produces the chimeric protein CBFβ-SMMHC and disrupts normal core-binding factor signaling. Rather than acting through enzymatic activity, this oncoprotein pro...
Multifactorial pathophysiology of varicocele: Integrating hemodynamic, oxidative, and endocrine mechanisms [0.03%]
阴囊静脉曲张的多因素病理生理机制：血流动力学、氧化和内分泌机制的整合
Wajid Mohammad Sheikh,Atif Khurshid Wani,Anum Shafi et al.
Wajid Mohammad Sheikh et al.
Varicocele is the most frequent surgically correctable cause of male factor infertility and the mechanisms underlying the detrimental impact of varicocele on testicular function are not fully understood. The current evidence suggests that v...
Comparative pathophysiology and pathology of transient ischemic attack, ischemic stroke, and reperfusion injury: Mechanistic and therapeutic perspectives [0.03%]
短暂性脑缺血发作、缺血性卒中和再灌注损伤的病理生理学和病理学：机制与治疗视角
Ji Hyeon Ahn,Moo-Ho Won
Ji Hyeon Ahn
Transient ischemic attack (TIA), ischemic stroke, and ischemia-reperfusion (IR) injury represent a continuum of cerebrovascular disorders with distinct clinical and pathophysiological features. While TIA is classically considered benign, re...
Taraxerol targets the HIF1A-NEK6 axis to block TDE-mediated M2 macrophage polarization and inhibits NSCLC progression [0.03%]
_taraxerol通过靶向HIF1A-NEK6轴阻断TDE介导的M2型巨噬细胞极化而抑制非小细胞肺癌进展
Qiang Yang,Hongli Li,Baojun Guo et al.
Qiang Yang et al.
Background: Non-small cell lung cancer (NSCLC) progression is tightly linked to tumor microenvironment (TME) remodeling. Taraxerol, a natural compound, has shown potential antitumor activity, but its molecular mechanisms ...
Tanshinone IIA promotes mitophagy by inhibiting the MARCHF5-mediated ubiquitination and degradation of FUNDC1 to alleviate spinal cord injury [0.03%]
丹参酮ⅡA通过抑制MARCHF5介导的FUNDC1泛素化降解促进线粒体自噬缓解脊髓损伤
Zhipeng Pan,Yuanmou Li,Xiaona He et al.
Zhipeng Pan et al.
Background: Spinal cord injury (SCI) has a poor prognosis and lacks effective treatment options. Dysfunction of mitophagy is involved in neuronal damage after SCI, and tanshinone IIA (TIIA) can regulate this process. This...
Rewiring lipid metabolism in diabetic kidney disease: Pathogenic networks and the therapeutic convergence of natural products [0.03%]
糖尿病肾病中的脂质代谢重建：病理网络及天然产物治疗的融合作用
Ying Pi,Liyuan Wen,Xinyuan Cheng et al.
Ying Pi et al.
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, and a growing body of evidence implicates disordered lipid metabolism as a central driver of its pathogenesis. This review examines renal lipid dysregulation in DK...