CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction
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Acute myeloid leukemia with inv(16) is defined by the CBFB::MYH11 fusion, which produces the chimeric protein CBFβ-SMMHC and disrupts normal core-binding factor signaling. Rather than acting through enzymatic activity, this oncoprotein promotes leukemogenesis... ...
