Inflammation promotes hepatic but not adipose tissue DGAT2 expression and triglyceride synthesis in MAFLD mice [0.03%]
炎症通过促进MAFLD小鼠肝内而非脂肪组织DGAT2表达和甘油三酯合成发挥作用
Balasubramaniyan Vairappan,Anjana Chandrasekar,Ravikumar T S
Balasubramaniyan Vairappan
This study primarily aimed to investigate whether superimposed inflammation in metabolic dysfunction associated fatty liver disease (MAFLD) enhances the expression of triglyceride (TG) synthesizing enzymes, acyl-CoA: diacylglycerol acyltran...
ZDBF2/SIRT6-mediated H3K27 deacetylation inhibits ferroptosis and reduces sensitivity of oral squamous cell carcinoma to cisplatin [0.03%]
ZDBF2/ SIRT6介导的H3K27去乙酰化抑制铁死亡并降低口腔鳞癌顺铂敏感性
Ke Liu,Liang Rong,Yi Shuai et al.
Ke Liu et al.
Objective and background: Oral squamous cell carcinoma (OSCC) is a common and aggressive malignant tumor. The circular RNA circZDBF2 derived from ZDBF2 is identified as an oncogenic factor in OSCC, but the role of ZDBF2 r...
Astragaloside IV ameliorates experimental autoimmune myasthenia gravis through multi-target regulation of immune-microbiota-metabolism network and ferroptosis inhibition [0.03%]
绞股蓝皂苷IV通过多靶点调节免疫-微生物组-代谢网络及铁死亡抑制改善实验性自身免疫性重症肌无力
Lin Xu,Yan Li,Zhilin He et al.
Lin Xu et al.
Background: Myasthenia gravis (MG) is an autoimmune disorder targeting neuromuscular junction proteins, with rising incidence and limited therapies. Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranace...
LGALS3BP promotes M1 polarization of macrophages and interacts with LGALS3, damaging endothelial function and exacerbating pulmonary arterial hypertension in systemic lupus erythematosus [0.03%]
LGALS3BP促进系统性红斑狼疮中M1型巨噬细胞极化并可与LGALS3结合，损伤内皮功能并加重肺动脉高压病理进展
Qifang Guo,Yijia Shao,Wei Zhou et al.
Qifang Guo et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems. Pulmonary arterial hypertension (PAH) is a rare but serious complication of SLE. However, the roles and underlying mechanisms of macrophages and e...
Interactions and communications in hepatocellular carcinoma: Potential targets for chemo/radiosensitization [0.03%]
肝细胞癌的相互作用和通讯：化疗/放疗增敏的潜在靶点
Xiu Yan,Xiaoying Dong,Liang Yao et al.
Xiu Yan et al.
Hepatocellular carcinoma (HCC) is known as one of the poor-prognosis malignancies. HCC stroma contains a complex ecosystem. Malignant cells in HCC orchestrate intricate cellular interactions and signaling networks to maintain expansion. The...
Piezo1-PHLPP2-PI3K/AKT axis represents a novel signalling cascade driving EMT and local invasion in colorectal cancer [0.03%]
压电蛋白1-磷脂酰肌醇二磷酸酶同系物补体样家族成员A2-磷脂酰肌醇/AKT轴代表结直肠癌上皮间质转化和浸润的新型信号转导通路
Xiaoyuan Ge,Lei Diao,Yongxin Zhang et al.
Xiaoyuan Ge et al.
Colorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide; invasion and metastasis are the principal causes of mortality. Epithelial-mesenchymal transition (EMT) is a pivotal driver of tumour dissemination. Piezo1, a mec...
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response [0.03%]
SIRT3通过内质网应激反应促进铁死亡从而提高奥沙利铂对肝癌细胞的敏感性
Yinkai Xu,Chuntao Ma,Xiaolan Xu et al.
Yinkai Xu et al.
Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide. The specific role of Sirtuin3 (SIRT3), a member of the Sirtuin family, in HCC, particularly regarding drug sensitivity, has not been fully elucidated. This study aimed to...
EASDnet: Empowering human-centered evidence-based medicine through an evidence and attention-based spatial disparity network for discriminative colorectal cancer histopathological screening and attribution [0.03%]
基于证据和注意力的空间差异网络赋能以人为中心的循证医学：用于鉴别直肠癌组织病理筛查与归因
Siming Zheng,Shaowen Bi
Siming Zheng
Purpose: Accurate preoperative staging of colorectal cancer is critical to guide treatment decisions, including eligibility for R0 resection, to reduce recurrence and improve patient survival. However, conventional imagin...
Adult ovarian granulosa cell tumor with high-grade hepatoid transformation: Case report and review of literature [0.03%]
成人卵巢颗粒细胞瘤伴高分化肝样转化1例报告及文献复习
Fan Yang,Jinhua Zheng,Xiaoqian Wang et al.
Fan Yang et al.
Adult Granulosa Cell Tumors (AGCTs) are uncommon ovarian neoplasms typically characterized by low-grade malignant behavior. However, AGCTs can occasionally undergo high-grade transformation, which may substantially impact clinical outcomes....
PD-L1 expression across urothelial carcinoma subtypes: A multicenter comparison of 22C3 and SP142 for clinical decision-making in the immunotherapy era [0.03%]
尿路上皮癌各亚型的PD-L1表达差异：免疫治疗时代临床决策中的22C3与SP142多中心对比研究
Juan Daniel Prieto Cuadra,Martina Álvarez Pérez,Pilar González-Peramato et al.
Juan Daniel Prieto Cuadra et al.
Background: Urothelial carcinoma with histological subtypes (UC-s) presents diverse biological behaviours and therapeutic responses. PD-L1 immunoexpression has become a key biomarker for guiding immune checkpoint inhibito...