Adipokine-mediated crosstalk between metabolic dysregulation and inflammatory pathways [0.03%]
脂肪细胞因子介导的代谢紊乱与炎症途径的相互作用
Zhiheng He,Linjie Zhao,Jiarui Liu et al.
Zhiheng He et al.
Adipokines are bioactive signaling molecules secreted by adipose tissue that play crucial roles in the regulation of energy metabolism and inflammatory responses. With the global rise in obesity and related metabolic disorders, understandin...
Yanping Zhang,Shazhou Ye,Suying Wang et al.
Yanping Zhang et al.
Bladder cancer (BCa) is the most common malignancy of the urinary system. Despite advancements in novel targeted therapies and immunotherapy, the majority of patients remain incurable, and disease progression frequently occurs after treatme...
New frontiers in rheumatoid arthritis therapy: From classic DMARDs to biologics and beyond [0.03%]
风湿性关节炎治疗的前沿进展：从传统改善病情抗风湿药到生物制剂及其他疗法
Vanshika,Puja Gulati,Ritika Thakur et al.
Vanshika et al.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder identified by persistent synovial inflammation, joint destruction, and systemic complications. Affecting approximately 0.5-1 % of the global population, RA poses a conside...
Progress in nanotechnology-based strategies to enhance tamoxifen therapy for breast cancer management [0.03%]
基于纳米技术的策略增强他莫昔芬疗法以改善乳腺癌治疗进展
Karthik Mangu,Aashna Nimish Gandhi,Md Rizwanullah
Karthik Mangu
Breast cancer (BC) remains a major cause of cancer-related mortality among women worldwide, with estrogen receptor-positive (ER+) tumors representing the most common subtype. Tamoxifen (TMX), a selective estrogen receptor modulator, has bee...
Multi-dimensional targeting of the tumor microenvironment to inhibit the invasion and metastasis of breast cancer [0.03%]
多维度靶向肿瘤微环境以抑制乳腺癌侵袭和转移
Yutong Wang,Qingshuang Wang,Jiahua Chang et al.
Yutong Wang et al.
The predominant cause of mortality in breast cancer patients arises from tumor invasion and metastasis. The tumor microenvironment (TME) plays an indispensable role in breast cancer development and progression. In recent years, intervention...
The clinical pathological significance of TLSs in HER2-low breast cancer [0.03%]
HER2低表达乳腺癌中TLS的临床病理意义分析
Zhixing Zhang,Wei Kang,Chunjun Li et al.
Zhixing Zhang et al.
Purpose: To investigate the presence and clinical significance of tertiary lymphoid structures (TLSs) in HER2-low breast cancer, by focusing on their associations with clinicopathological features and prognosis. ...
HER2 immunoreactivity in advanced non-p53abn endometrial carcinoma: Association with clinical features, prognosis, and molecular characteristics [0.03%]
HER2免疫反应与晚期非p53abn子宫内膜癌的临床特征、预后和分子特征之间的关联
Yining Zhen,Yinbo Xiao,Yang Zhou et al.
Yining Zhen et al.
Background: Human epidermal growth factor receptor 2 (HER2) is an emerging therapeutic target in endometrial carcinoma (EC). Current guidelines recommend routine HER2 testing for p53 abnormal (p53abn) tumors, potentially ...
ACLP promotes hypertrophic scar pathogenesis by enhancing myofibroblast activation and cholesterol synthesis-related gene expression [0.03%]
ACLP通过增强肌成纤维细胞活化和胆固醇合成相关基因表达促进增生性疤痕病理发生
Yi Shi,Yajuan Song,Tong Wang et al.
Yi Shi et al.
Background: Hypertrophic scar (HS) is a severe fibrotic disease characterized by excessive fibroblast activation and extracellular matrix deposition. While previous studies have revealed the involvement of Aortic Carboxyp...
Clinicopathological features and mutational landscape of colorectal cancer subgroups defined by MSI and EMAST status [0.03%]
微卫星不稳定状态和EMAST状态定义的结直肠癌亚组的临床病理特征及基因突变图谱分析
Tamara Cacev,Kristina Vuković Đerfi,Anamarija Salar et al.
Tamara Cacev et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality. Microsatellite instability-high (MSI-H) tumors, resulting from defective DNA mismatch repair (MMR), represent a well-defined subtype with distinctive...
Molecular regulation and therapeutic targeting of programmed cell death in hepatocellular carcinoma [0.03%]
肝细胞癌程序性细胞死亡的分子调控和治疗靶向研究
Yu Zhao,Liuxin Yang,Peng Wang et al.
Yu Zhao et al.
Background: Hepatocellular carcinoma (HCC) is a global health challenge with limited treatment options, largely due to the ability of tumor cells to evade programmed cell death (PCD). Dysregulation of key PCD pathways; ap...