Emerging Landscape of CAR-T Cell Therapy in Colon Cancer: Mechanistic Insights, Clinical Advances, Challenges, and Future Directions [0.03%]
CAR-T细胞治疗结直肠癌的现状：机制、临床进展、挑战与未来方向
Arif Raza,Mohammad Adnan Raza,Junaid Khan et al.
Arif Raza et al.
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies; however, its clinical translation to solid tumors, including colon cancer, remains challenging. This review comprehensively exa...
Integrated morphologic, immunophenotypic, and molecular profiling of advanced upper tract urothelial carcinoma across tumor compartments supports biopsy-based testing [0.03%]
整合形态学、免疫表型和分子谱分析晚期输尿管尿路上皮癌的不同肿瘤组织支持活检检测
Filippo Maria Martelli,Giuseppe Nicolò Fanelli,Lavinia Stefanizzi et al.
Filippo Maria Martelli et al.
Upper tract urothelial carcinoma (UTUC) is an aggressive malignancy with limited molecular characterization in advanced disease. FGFR3 alterations are well established in low-grade urothelial carcinoma, but their prevalence, stability, and ...
CircRNA hsa_circ_0001946 promotes hypertrophic scar pathogenesis via the miR-514a-3p/COL5A2 axis [0.03%]
circRNA hsa_circ_0001946通过miR-514a-3p/COL5A2轴促进增生性瘢痕发病机制
Yi Shi,Yajuan Song,Tong Wang et al.
Yi Shi et al.
Hypertrophic scars (HSs) represent a fibroproliferative disorder characterized by excessive extracellular matrix deposition. However, the underlying regulatory mechanisms involving circular RNAs (circRNAs) have not yet been fully elucidated...
Targeting T-cell exhaustion and tumour immune evasion: a review of emerging strategies [0.03%]
靶向T细胞衰竭和肿瘤免疫逃避：新兴策略述评
Leticija Saltis,Liew Jun Mun
Leticija Saltis
Adoptive T-cell therapies and immune checkpoint blockade have produced durable remissions in selected malignancies, yet most patients still fail to achieve lasting benefit. Two convergent obstacles underlie much of this failure: T-cell exha...
Prediction of microsatellite instability in colorectal cancer based on tissue phenotypes inferred from pathological whole slide images using self-distillation [0.03%]
基于病理全滑片图像的自蒸馏法推断组织表型预测结直肠癌微卫星不稳定性
Zhiwu Wang,Yankun Liu,Wei Xiong et al.
Zhiwu Wang et al.
The application of Multiple Instance Learning (MIL) for classifying Whole Slide Images (WSIs) has gained extensive use in recent years, primarily due to the high cost and time consumption associated with pixel-level annotation of WSIs, whic...
A two-stage genome-wide association study to identify germline polymorphisms associated with survival of nasopharyngeal carcinoma [0.03%]
两阶段全基因组关联研究识别与鼻咽癌患者生存率相关的遗传多态性
Tong Li,LuLu Yu,XiaoXue Xie et al.
Tong Li et al.
Background: The effect of genetic polymorphisms on survival outcomes in nasopharyngeal carcinoma (NPC) has not been fully elucidated. This study aimed to identify genetic variants associated with NPC survival using a geno...
DDIT3 inhibition by salvianolic acid B mitigates Fusobacterium nucleatum-mediated chemoresistance to 5-fluorouracil in colorectal cancer [0.03%]
丹参素B通过抑制DDIT3缓解FN介导的结直肠癌5-氟尿嘧啶化疗耐药性
Liangyu Zhang,Wei Wen,Xianyan Lu
Liangyu Zhang
Background: Fusobacterium nucleatum (Fn) drives chemotherapy resistance in colorectal cancer (CRC) by activating hypoxia-mimicking signaling pathways, yet the molecular mechanisms linking Fn to 5-fluorouracil (5-FU) resis...
Immune-angiogenic crosstalk in glioblastoma: Mechanisms and therapeutic opportunities [0.03%]
胶质母细胞瘤中的免疫新生互作：机制与治疗策略
Sumaya Islam Supty,S M Sertaz Islam,Atia Tanzum Mollik Riea et al.
Sumaya Islam Supty et al.
Glioblastoma (GBM) remains the most aggressive and therapeutically challenging primary brain tumor and is characterized by strong heterogeneity, rapid progression, and poor clinical outcomes. Accumulating evidence indicates that the immune-...
Regulation of FN1 levels in endometrial cancer cells: Probiotics activate the p62-dependent autophagy-lysosome pathway to reduce tumor metastasis [0.03%]
乳酸菌激活p62依赖的自噬-溶酶体途径调节子宫内膜癌细胞FN1水平并抑制肿瘤转移
Shuqi Ji,Helun Sun,Xianchao Kong
Shuqi Ji
Background: Endometrial cancer (EC) is a common female reproductive system malignancy, with metastasis being a major cause of poor prognosis. Intestinal flora imbalance is linked to gynecological tumor progression, and pr...
RRM2 promotes lung adenocarcinoma progression and is associated with ferroptosis-inducer sensitivity through the NRF2/GPX4 signaling axis [0.03%]
RRM2促进肺腺癌进展并影响对铁死亡诱导剂敏感性通过NRF2/GPX4信号轴
Xiangyuan Li,Fenfen Gu,Rong Xiao et al.
Xiangyuan Li et al.
Background: Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, characterized by aggressive progression and therapy resistance. Ferroptosis, an iron-dependent form of regulated cell death, has emerg...