Advanced hierarchical computational modeling-based rational development of platinum (II) nanocomplex to improve lung cancer therapy [0.03%]
基于高级层次计算模型的铂(II)纳米复合物的设计开发及其对肺癌治疗的改善作用
Haozhe Huang,Beihong Ji,Yixian Huang et al.
Haozhe Huang et al.
Cancer stem cells (CSCs), harboring stem cell-like properties involving self-renewal and aberrant differentiation potential, have been known to be one of the determining factors that contribute to therapeutic resistance and tumor recurrence...
Modular Anti-Counterfeit Tags Formed by Template-Assisted Self-Assembly of Plasmonic Nanocrystals and Authenticated by Machine Learning [0.03%]
基于模板辅助等离激元纳米粒子自组装的防伪标签及其机器学习鉴别方法
Maha Ibrar,Sheng-Yuan Huang,Zachery McCurtain et al.
Maha Ibrar et al.
Counterfeit goods are pervasive, being found in products as diverse as textiles and optical media to pharmaceuticals and sensitive electronics. Here, an anti-counterfeit platform is reported in which plasmonic nanoparticles (NPs) are used t...
Michelle Makhoul Mansour,Joshua J Maraj,Robert Jordan Pyron et al.
Michelle Makhoul Mansour et al.
Modeled after biological neurons, neuristors are emerging hardware that generate recurring voltage spikes in response to electrical stimulation. This type of excitability could enable transistor-free spiking neural networks for efficient si...
Exosomal Bupivacaine: Integrating Nerve Barrier Penetration Capability and Sustained Drug Release for Enhanced Potency in Peripheral Nerve Block and Reduced Toxicity [0.03%]
布比卡因exo囊泡：整合神经屏障穿透能力和持续药物释放以增强周围神经阻滞的效力并减少毒性
Yuhao Cai,Qi Li,Ursula Wesselmann et al.
Yuhao Cai et al.
Peripherally injected local anesthetics exhibit limited ability to penetrate peripheral nerve barriers (PNBs), which limits their effectiveness in peripheral nerve block and increases the risk of adverse effects. In this work, we demonstrat...
Engineered zwitterionic diblock copolymer-siRNA polyplexes provide highly effective treatment of triple-negative breast cancer in a 4T1 murine model [0.03%]
工程两性嵌段共聚物-siRNA多聚复合物可有效治疗三阴乳腺癌4T1小鼠模型中的肿瘤疾病
Taewon Jeon,Ritabrita Goswami,Harini Nagaraj et al.
Taewon Jeon et al.
Self-assembly of siRNA with a block copolymer featuring guanidinium and zwitterion functionalized blocks generates core-shell-like nanovectors that provide cytosolic access to siRNA and efficiently evade phagocytic clearance. The guanidiniu...
Wireless Peristaltic Pump for Transporting Viscous Fluids and Solid Cargos in Confined Spaces [0.03%]
用于在狭窄空间运输粘性流体和固体货物的无线蠕动泵
Saksham Sharma,Laura Caroline Jung,Nicholas Lee et al.
Saksham Sharma et al.
The transport of fluids and solids is a vital process inside the human body, facilitated by the wave-like motion in the lumen called peristalsis. However, peristalsis may be compromised due to tumor growth, resulting in difficulties in lume...
Sensing Mucus Physiological Property In Situ by Wireless Millimeter-Scale Soft Robots [0.03%]
通过无线毫米级软体机器人现场感知黏液生理特性
Boyang Xiao,Yilan Xu,Steven Edwards et al.
Boyang Xiao et al.
The physiological property of mucus is an important biomarker for monitoring the human health conditions and helping understand disease development, as mucus property such as viscosity is highly correlated with inflammation and other diseas...
Synthetic photoresponsive hydrogels enable in situ control over murine intestinal monolayer differentiation and crypt formation [0.03%]
合成光响应水凝胶能够实现对鼠肠上皮单层分化和隐窝形成进行原位控制
Mark W Young,Colter E Oroke,Bruce E Kirkpatrick et al.
Mark W Young et al.
As a model of the intestinal epithelium, intestinal stem cells (ISCs) have been grown and differentiated as monolayers on materials where stochastic organization of the crypt and villi cells occurs. We developed an allyl sulfide crosslinked...
N-Dihydrogalactochitosan Drives Conventional and Alternative Activations of STING to Synergize Type I IFN and IL-1β Productions for Antitumor Immunity [0.03%]
N-二氢半乳糖壳寡糖驱动STING的常规和替代激活作用协同促进I型干扰素和IL-1β产生以增强抗肿瘤免疫反应
Ashley R Hoover,Kaili Liu,Coline Furrer et al.
Ashley R Hoover et al.
N-dihydrogalactochitosan (GC) is an immune stimulant/adjuvant. Synthesized from chitosan and galactose, GC is a new chemical entity that significantly enhances the immune-stimulating properties of its parental material, chitosan, making it ...
Ranking Magnetic Colloid Performance for Magnetic Particle Imaging and Magnetic Particle Hyperthermia [0.03%]
磁性颗粒成像和磁性颗粒热疗用磁性溶胶性能的评价
Hayden Carlton,Marzieh Salimi,Nageshwar Arepally et al.
Hayden Carlton et al.
Magnetic particle imaging (MPI) is an emerging modality that can address longstanding technological challenges encountered with magnetic particle hyperthermia (MPH) cancer therapy. MPI is a tracer technology compatible with MPH for which ma...